A Concentrated Review of Current Developments in the Diagnosis and Treatment of Viral Mumps

Year : 2024 | Volume :01 | Issue : 01 | Page : 01-07
By

Mohammed Nadeem Khan

Ashok Kumar

Praveen Chandra Dubey

Abstract

Viral mumps, caused by the mumps virus, continues to pose public health challenges globally despite the availability of vaccines. Considerable advancements have been achieved in the last few years about the pathophysiology, diagnosis, and management of viral mumps. This focused review aims to highlight the latest advances in the diagnosis and treatment of viral mumps, with a particular emphasis on innovative strategies and emerging therapies. Key topics covered include the evolution of diagnostic techniques such as molecular assays and serological tests, novel biomarkers for disease detection and monitoring, advances in antiviral therapies and supportive care, including the use of antiviral medications and immunomodulatory agents. Additionally, we discuss challenges in diagnosis, management, and prevention of viral mumps, including vaccine hesitancy and outbreaks in various populations. By summarizing recent developments, this review provides clinicians and researchers with valuable insights into optimizing the diagnosis and management of viral mumps, ultimately contributing to improved patient outcomes and the control of mumps outbreaks

Keywords: Viral mumps, mumps virus, diagnosis, treatment, biomarkers, antiviral therapy, immunomodulatory agents, vaccine hesitancy, outbreaks

[This article belongs to International Journal of Tropical Medicines(ijtm)]

How to cite this article: Mohammed Nadeem Khan, Ashok Kumar, Praveen Chandra Dubey. A Concentrated Review of Current Developments in the Diagnosis and Treatment of Viral Mumps. International Journal of Tropical Medicines. 2024; 01(01):01-07.
How to cite this URL: Mohammed Nadeem Khan, Ashok Kumar, Praveen Chandra Dubey. A Concentrated Review of Current Developments in the Diagnosis and Treatment of Viral Mumps. International Journal of Tropical Medicines. 2024; 01(01):01-07. Available from: https://journals.stmjournals.com/ijtm/article=2024/view=144764





References

  1. American Academy of Pediatrics. Mumps. In: Kimberlin DW, Barnett ED, Lynfield R, Sawyer MH, editors. Red Book: 2021 report of the Committee on Infectious Diseases. 32ndElk Grove Village, IL: American Academy of Pediatrics; 2021:538–43.
  2. Reed D, Brown G, Merrick R, Sever J, Feltz E. A mumps epidemic on St. George Island, Alaska. JAMA 1967;199(13):113–7.
  3. Falk WA, Buchan K, Dow M, et al. The epidemiology of mumps in southern Alberta, 1980–1982. Am J Epidemiol 1989;130(4):736–49.
  4. Johnstone JA, Ross CA, Dunn M. Meningitis and encephalitis associated with mumps infection. A 10-year survey. Arch Dis Child 1972;47(254):647–51.
  5. Beard CM, Benson RC Jr, Kelalis PP, et al. The incidence and outcome of mumps orchitis in Rochester, Minnesota, 1935 to 1974. Mayo Clin Proc. 1977;52(1):3–7.
  6. Barskey AE, Schulte C, Rosen JB, et al. Mumps outbreak in Orthodox Jewish communities in the United States. N Engl J Med. 2012;367(18):1704–13.
  7. Dayan, GH, Quinlisk MP, Parker AA, et al. Recent resurgence of mumps in the United States. N Engl J Med 2008;58(151):580–9.
  8. Update: mumps outbreak—New York and New Jersey, June 2009–January 2010. MMWR Morb Mortal Wkly Rep. 2010;59(5):125–9.
  9. Nelson EG, Aguon A, Valencia E, et al. Epidemiology of a mumps outbreak in a highly vaccinated island population and use of a third dose of measles–mumps–rubella vaccine for outbreak control—Guam 2009 to 2010. Pediatr Infect Dis J 2013;32(4):374–80.
  10. Masarani M, Wazait H, Dinneen M. Mumps orchitis. J R Soc Med. 2006;99(11):573–5.
  11. Rubin S, Eckhaus M, Rennick LJ, et al. Molecular biology, pathogenesis and pathology of mumps virus. J Pathol 2015:235(2):242–52.
  12. Havlíčková M, Limberková R, Smíšková D, et al. Mumps in the Czech Republic in 2013: clinical characteristics, mumps virus genotyping, and epidemiological links. Cent EurJPublicHealth 2016:24(1):22–8.
  13. Orlikova H, Malý M, Lexová P, et al. Protective effect of vaccination against mumps complications, Czech Republic, 2007–2012. BMC Public Health 2016;16:293.
  14. Everberg G. Deafness following mumps. Acta Otolaryngol 1957;48(5–6):397–403.
  15. Vuori M, Lahikainen EA, Peltonen T. Perceptive deafness in connection with mumps: a study of 298 servicemen suffering from mumps. Acta Otolaryngol 1962;55:231–6.
  16. Yung CF, Andrews N, Bukasa A, et al. Mumps complications and effects of mumps vaccination, England and Wales, 2002–2006. Emerg Infect Dis 2011;17(4):661–7.
  17. Kutty PK, Kyaw MH, Dayan GH, et al. Guidance for isolation precautions for mumps in the United States: A review of the scientific basis for policy change. Clin Infect Dis 2010;50(12):1619–28.
  18. Cooney MK, Fox JP, Hall CE. The Seattle Virus Watch: VI. Observations of infections with and illness due to parainfluenza, mumps and respiratory syncytial viruses and Mycoplasma pneumoniae. Am J Epidemiol 1975;101(6):532–51.
  19. Updated recommendations for isolation of persons with mumps. MMWR Morb Mortal Wkly Rep2008;7(40):1103–5.
  20. Rota JS, Rosen JB, Doll MK, et al. Comparison of the sensitivity of laboratory diagnostic methods from a well-characterized outbreak of mumps in New York City in 2009.Clin Vaccine Immunol 2013;20(3):391–6.
  21. Nunn A, Masud S, Krajden M, et al. Diagnostic yield of laboratory methods and value of viral genotyping during an outbreak of mumps in a partially vaccinated population in British Columbia, Canada. J Clin Microbiol 2018;56(5):e01954–17.
  22. Marin M, Quinlisk P, Shimabukaro T, et al. Mumps vaccination coverage and vaccine effectiveness in a large outbreak among college students—Iowa, 2006. Vaccine 2008;26(29-30):3601–7.
  23. Utz JP, Szwed CF, Kasel JA. Clinical and laboratory studies of mumps. II. Detection and duration of excretion of virus in urine. Proc Soc Exp Biol Med 1958;99(1)259.
  24. Jalal H, Bahadur G, Knowles W, et al. Mumps epididymo-orchitis with prolonged detection of virus in semen and the development of anti-sperm antibodies. J Med Virol 2004;73(1):147–50.
  25. Siegel M, Fuerst HT, Peress NS. Comparative fetal mortality in maternal virus diseases. A prospective study on rubella, measles, mumps, chicken pox and hepatitis. N Engl J Med 1966;274(14):768–71.
  26. Litman N, Baum SG. Mumps virus. In: Bennett JE, Dolin R, Blaser MJ. editors. Principles and practice of infectious diseases. 9thPhiladelphia, PA: Churchill Livingstone/Elsevier; 2019: 2087–92.
  27. Rubin SA. Mumps vaccine. In: Orenstein WA, Offit PA, Edwards KM, Plotkin SA Vaccines. 8th Philadelphia, PA: Sanders/Elsevier; 2023:711-736.e10.
  28. Mumps vaccine. Recommendation of Public Health Service Advisory Committee on Immunization Practices. MMWR Morb Mortal Wkly Rep 1977;26(48):393–4.
  29. Measles prevention. MMWR Morb Mortal Wkly Rep1989; 38(Suppl 9):1–18.
  30. Prevention of measles, rubella, congenital rubella syndrome, and mumps, 2013 summary recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2013; 2(RR-04):1–34.
  31. Current trends mumps—United States, 1985–1988. MMWR Morb Mortal Wkly Rep1989;38(7):101–5.
  32. Briss PA, Fehrs LJ, Parker RA, et al. Sustained transmission of mumps in a highly vaccinated population: assessment of primary vaccine failure and waning vaccine-induced immunity. J Infect Dis 1994;169(1):77–82.
  33. Hersh BS, Fine PE, Kent WK, et al. Mumps outbreak in a highly vaccinated population. J Pediatr 1991;119(2):187–93.
  34. Summary of notifiable diseases — United States, 2003. MMWR Morb Mortal Wkly Rep 2005;52(54).
  35. Summary of notifiable diseases — United States, 2007. MMWR Morb Mortal Wkly Rep 2009;56(53).
  36. Summary of notifiable diseases — United States, 2008. MMWR Morb Mortal Wkly Rep 2010;57(54).
  37. Clemmons NS, Redd SB, Gastañaduy PA, et al. Characteristics of large mumps outbreaks in the United States, July 2010–December 2015. Clin Infect Dis 2019;68(10):1684–90.
  38. National Notifiable Diseases Surveillance System, 2017 Annual Tables of Infectious Disease Data. Atlanta, GA: CDC; 2018.
  39. National Notifiable Diseases Surveillance System, 2016 Annual Tables of Infectious Disease Data. Atlanta, GA: CDC; 2017.

Regular Issue Subscription Review Article
Volume 01
Issue 01
Received March 28, 2024
Accepted April 6, 2024
Published May 1, 2024