Synthesis Innovative Cyclic Formazan Compounds for the First Time and Evaluation of Their Biological Activity

Open Access

Year : 2021 | Volume : | Issue : 2 | Page : 5-12
By

    Nagham Mahmood Aljamali

Abstract

The research included the invention of cyclic formazan compounds for the first time in this research that carried out in April 2021, where the usual formazan compounds were previously attended, but in the current research we attended the cyclic formazan compounds as innovative compounds and after that they were diagnosed by reliable chemical means of measurement, that provided vibrant indication of their chemical constructions via numerous technical apparatuses similar (FT IR-Bands, 1H.NMRPeeaks, Mass-Identification). Melting points, other studies represented by antimicrobial Evaluation., These Compounds have been distinguished by their bright colors and their using as fixed dyes for many tissues and as anti-corrosion materials , and as a ligands with transitional elements as coordination complexes., The results appeared good evidence for efficiency of Innovative Cyclic formazan derivatives that compounds gave high inhibition in bacteria more than other compounds via creation of band of formazan (-N=C-N=N-) in innovated derivative more than initial materials beginning Aldamine compounds that produced inhibition action of bacteria.

Keywords: Cyclic formazan, formazan, imine, schiff base, Azo, antimicrobial study.

[This article belongs to International Journal of Polymer Science & Engineering(ijpse)]

How to cite this article: Nagham Mahmood Aljamali Synthesis Innovative Cyclic Formazan Compounds for the First Time and Evaluation of Their Biological Activity ijpse 2021; 7:5-12
How to cite this URL: Nagham Mahmood Aljamali Synthesis Innovative Cyclic Formazan Compounds for the First Time and Evaluation of Their Biological Activity ijpse 2021 {cited 2021 Dec 31};7:5-12. Available from: https://journals.stmjournals.com/ijpse/article=2021/view=91450

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References

1. Nagham Mahmood Aljamali. Inventing of Macrocyclic Formazan Compounds and Studying Them Against Breast Cancer for The first Time Globally. Annals of pharma research. 2021; 9 (7): 525-533. Available at:https://www.annalsofpharmaresearch.com/index.php?journal=apr&page =article&op=view&path%5B%5D=38.
2. Nagham Mahmood Aljamali. Creation of Innovated Macrocyclic Sulfazan-Formazan Compounds and Linear Sulfazan-Formazan for the first Time Globally with their Assay as Antifungal., Biomedical. Journal of Scientific & Technical Research. 2021; 40(3): 32266-3227, DOI: 10.26717/BJSTR.2021.40.006453.
3. Nagham Mahmood Aljamali. Review on (Azo, Formazane, Sulfazane)-Compounds. International Journal of Innovations in Scientific Engineering. 2019; 10: 19-45.
4. Grant CM. Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions””. Molecular Microbiology. 2001; 39(3): 533–541. doi:10.1046/j.1365-2958.2001.02283.x.
5. Miad Mohmed, Sabreen Ali Abdalrahman., Wassan Ala Shubber., et.al. Formation of Oxadiazole Derivatives Ligands from Condensation and Imination Reaction with References To Spectral Investigation, Thermal and Microbial Assay. Biochem. Cell. Arch. 2018;18(1): 847-853.
6. Nagham Mahmood Aljamali. The Various Preparation Methods in Synthetic Chemistry.1st ed. Chattisgarh, India: Evincepub Publishing house. 2019. ISBN :978-93-88277-82-2.
7. Nagham Mahmood Aljamali. Reactions and Mechanisms. 1st ed. IJMRA Publication. 2018. ISBN: 978- 93-87176-25-6.
8. Nagham Mahmood Aljamali. Experimental Methods for Preparation of Mannich Bases, Formazan, Normal and Cyclic Sulfur Compounds. 1st edition. Chattisgarh, India: Evince pub Publishing House; 2018. ISBN: 978-93-87905-19-1.
9. Nagham Mahmood Aljamali. Alternative Methods in Organic Synthesis. 1th–Edition. Europe: Eliva Press SRL; 2020. ISBN: 9798680201176.
10. Nagham Mahmood Aljamali. Effect of Conditions and Catalysis on Products. 1st Ed. Europe: Eliva Press SRL; 2021. ISBN: 9781636482286.
11. Nagham Mahmood Aljamali. Synthesis and Biological Study of Hetero (Atoms and Cycles) Compounds. Der Pharma Chemica. 2016; 8(6): 40-48.
12. Matheus ME, de Almeida Violante F, Garden SJ. Isatins inhibit cyclooxygenase-2 and inducible nitric oxide synthase in a mouse macrophage cell line. Eur J Pharmacol. 2007; 556(1-3) :200–206.
13. Karm Alan, Hasaneen Kudhair Abdullabass, et.al. Invention of (Gluta. Sulfazane-Cefixime) Compounds as Inhibitors of Cancerous Tumors. Journal of Cardiovascular Disease Research. 2020; 11(2): 44-55. DOI: 10.31838/jcdr.2020.11.02.09.
14. Nagham Mahmood Aljamali. Synthesis and Chemical Identification of Macro Compounds of (Thiazol and Imidazol). Research J. Pharm. and Tech. 2015; 8(1): 78-84. DOI: 10.5958/0974-360X.2015.00016.5.
15. Mestaf M, Nawfel Muhammed Baqer Muhsin., NeuroQuantology, 2019.,17,11, 11-16.,10.14704/nq.2019. 17.11.NQ19108.
16. Nagham Mahmood Aljamali. Synthesis of Antifungal Chemical Compounds from Fluconazole with (Pharma-Chemical) Studying. Research journal of Pharmaceutical, biological and chemical sciences. 2017; 8 (3): 564 -573.
17. Mehta SL, Manhas N, Raghubiz R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Rev. 2007; 54: 34–66.
18. Meaaed M, Nagham Mahmood Aljamali, Nadheema A A. Preparation, Spectral Investigation, Thermal Analysis, Biochemical Studying of New (Oxadiazole -Five Membered Ring)-Ligands. Journal of Global Pharmacy Technology. 2018;10(1): 20-29.
19. Nagham Mahmood Aljamali. Survey on Methods of Preparation and Cyclization of Heterocycles. International Journal of Chemical and Molecular Engineering. 2020; 6(2): 19–36.
20. Mieaad M, Wassan Ala Shubber., Sabreen Ali Abdalrahman, et.al. New Azomethine- Azo Heterocyclic Ligands Via Cyclization of Ester. Research Journal of Pharmacy and Technology. 2018; 11(6): 2555-2560., DOI: 10.5958/0974-360X. 2018. 00472.9 .
21. Hasaneen Kudhair Abdullabass, Aseel Mahmood Jawad, et.al. Synthesis of drugs derivatives as inhibitors of cancerous cells., Biochem. Cell. Arch. 2020; 20(2). DocID: https://connectjournals.com/03896.2020.20.5315.
22. Nagham Mahmood Aljamali, Intisar Obaid Alfatlawi. Synthesis of Sulfur Heterocyclic Compounds and Study of Expected Biological Activity. Research J. Pharm. and Tech. 2015; 8(9): 1225-1242. DOI: 10.5958/0974-360X.2015 .00224.3.
23. Nagham Mahmood Aljamali, Kam Alwan. Development of Trimethoprim Drug and Innovation of Sulfazane-Trimethoprim Derivatives as Anticancer Agents. Biomedical & Pharmacology Journal. 2020; 13(2): 613-625. http://dx.doi.org/10.13005/bpj/1925.
24. Hussein Ali Ahmed, Nagham Mahmood Aljamali. Preparation, Characterization, Antibacterial Study, Toxicity Study of New Phenylene diamine- Formazan Derivatives. Indian Journal of Forensic Medicine & Toxicology. 2021; 15(2).
25. Nagham Mahmood Aljamali, Hussein Mejbel Azeez. Synthesis and Characterization of Some New Formazan – Cefixime and Study of Against Breast Cancer Cells. Annals of R.S.C.B. 2021; 25(4): 8562-8578. ISSN:1583-6258.
26. Nagham Mahmood Aljamali, Asmaa, Kefah Mahdi. Synthesis, Identification and Anticancer Studying of Heterocyclic- Mefenamic Drug via Thiosemicarbazide., Annals of R.S.C.B. 2021; 25(4): 8521-8537. ISSN:1583-6258.
27. Nagham Mahmood Aljamali, Tabark Emad Al-Faham. Synthesis, Identification, Chromatographic Studying of Formazane –Phenylenediamine Derivatives., Annals of R.S.C.B., ISSN:1583-6258, Vol. 25, Issue 4, 2021.
28. Intisar Obaid Alfatlawi, Nuha S S, Zainab M J., et.al. Synthesis of New Organic Compounds Via Three Components Reaction with Studying of (Identification, Thermal Behavior, Bioactivity on Bacteria of Teeth). Journal of Global Pharma Technology. 2017;11(9): 157-164.
29. Naumann d’Alnoncourt, Raoul; Csepei, Lénárd-István; Hävecker, Michael; et.al. The reaction network in propane oxidation over phase-pure MoVTeNb M1 oxide catalysts. Journal of Catalysis. 2014;311: 369–385.
30. Nagham Mahmood Aljamali.; Saher Mahmood Jawd.; Zainab M J., et.al. Inhibition activity of (Azo–acetyl acetone) on bacteria of mouth. Research Journal of Pharmacy and Technology. 2017; 10(6):1683-1686. DOI: 10.5958/0974-360X.2017.00297.9.
31. Mokrani, Touhami; van Reenen, Albert; Amer, Ismael. Molecular weight and toxicity effect on morphological and mechanical properties of Ziegler–Natta catalyzed isotactic polypropylenes””. Polímeros. 2015; 25(6): 556–563. doi:10.1590/0104-1428.2158 . ISSN 0104-1428.
32. Dub, Pavel A.; Gordon, John C.The role of the metal-bound N–H functionality in Noyori-type molecular catalysts””. Nature Reviews Chemistry. 2018; 2(12): 396–408.
33. Nagham Mahmood Aljamali. (Synthesis, Investigation, Chromatography, Thermal)- Behavior of (Five, Seven)- Membered Ring with Azo and Anil Compounds. Pak. J. Biotechnol. 2018; 15(1): 219-239.
34. Aseel Mahmood Jawad., Nagham Mahmood Aljamali, Saher Mahmood Jawd. Development and Preparation of ciprofloxacin Drug Derivatives for Treatment of Microbial Contamination in Hospitals and Environment. Indian Journal of Forensic Medicine & Toxicology. 2020; 14(2): 1115-1122.
35. Nagham Mahmood Aljamali. Spectral and Laboratory Diagnostics of Compounds. 1st –Edition. Europe: Eliva Press SRL; 2021. ISBN: 9781636482118.
36. Shireen R. Rasool, Nagham Mahmood Aljamali, Ali Jassim Al-Zuhairi. Guanine substituted heterocyclic derivatives as bioactive compounds. Biochem. Cell. Arch. 2020; 20: 3651-3655, 2020, DocID: https://connectjournals.com/03896.2020.20.3651.
37. Pompella A, Visvikis A, Paolicchi A, et.al. The changing faces of glutathione, protagonist””. Biochemical Pharmacology. 2003; 66(8):1499–1503.doi:10.1016/S0006-2952 (03) 00504-5.
38. Wonisch W, Schaur RJ. Chapter 2: Chemistry of Glutathione””. In Grill D, Tausz T, De Kok L (eds.). Significance of glutathione in plant adaptation to the environment. Germany: Springer; 2001. ISBN 978-1-4020-0178-9 – via Google Books.
39. Aljamali D, Mahmood N, Jawad SF. Preparation, Spectral Characterization, Thermal Study, and Antifungal Assay of (Formazane-Mefenamic acid)-Derivatives. Egyptian Journal of Chemistry. 2022; 65(2): 449-457.
40. Pastore A, Piemonte F, Locatelli M, et.al. Determination of blood total, reduced, and oxidized glutathione in pediatric subjects. Clinical chemistry. 2001;47(8):1467-1470.
41. Lu SC (2013). Glutathione synthesis. Biochimica et Biophysica Acta. 2013; 1830(5): 3143–3153. doi:10.10 16/j.bbagen.2012.09.008. PMC 3549305. PMID 22995213.
42. Halprin KM, Ohkawara A. The measurement of glutathione in human epidermis using glutathione reductase””. The Journal of Investigative Dermatology. 1967; 48(2): 149–152. doi:10.1038/jid.1967.24 . PMID 6020678.
43. Couto N, Malys N, Gaskell SJ, et.al. Partition and turnover of glutathione reductase from Saccharomyces cerevisiae: a proteomic approach””. Journal of Proteome Research. 2013; 12(6): 2885–2894. doi:10.1021 /pr4001948. PMID 23631642.
44. Dringen R. Metabolism and functions of glutathione in brain””. Progress in Neurobiology. 2000; 62(6): 649–671. doi:10.1016/s0301-0082(99)00060-x. PMID 10880854.
45. Scholz, RW. Graham KS. Gumpricht E. et.al. Mechanism of interaction of vitamin E and glutathione in the protection against membrane lipid peroxidation””. Ann NY Acad Sci. 1989; 570(1): 514–517. Bibcode:1989NYASA. 570.514S. doi:10.1111/j.1749-6632.1989.tb14973.x.
46. Hughes RE. Reduction of dehydroascorbic acid by animal tissues. Nature. 1964; 203(4949): 1068–1069. Bibcode: 1964Natur.203.1068H. doi:10.1038/2031068a0. PMID 14223080.
47. Ha SB, Smith AP, Howden R, et.al. Phytochelatin synthase genes from Arabidopsis and the yeast Schizosaccharomyces pombe. The Plant Cell. 1999; 11(6): 1153–1164. doi:10.1105/tpc.11.6.1153. JSTOR 3870806 . PMC 144235. P MID 10368185.
48. Steullet P, Neijt HC, Cuénod M, et.al. Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia. Neuroscience. 2006; 137(3): 807–819. doi:10.1016/j.neuroscience.2005.10.014 . PMID 16330153.
49. Aseel Mahmood Jawad, Nagham Mahmood Aljamali. Innovation, Preparation of Cephalexin Drug Derivatives and Studying of (Toxicity & Resistance of Infection). International Journal of Psychosocial Rehabilitation. 2020; 24(4): 3754-3767.
50. Nawfel M B, Hayder H K, Noor H D, et.al. Preparation of Chemical Inhibitors to Treat the Corrosion and Erosion of Machines. International Journal of Engineering, Applied and Management Sciences Paradigms. 2019; 54(3): 89-93.
51. Maulucci G, Labate V, Mele M, et.al. High-resolution imaging of redox signaling in live cells through an oxidation-sensitive yellow fluorescent protein. ScienceSignaling. 2008; 1 (43):pl3. doi:10.1126/scisignal .143pl3.
52. M. N Abdmajed, Nagham Mahmood Aljamali., Preparation of Benzothiazole-Formazane Reagents and Studying of (Spectral, Thermal, Scanning Microscopy, Biological Evaluation)., International Journal of Pharmaceutical Research. 2021;13(1): 4290-4300.
53. Abd Ali H, Nagham Mahmood Aljamali. Chalcone-Heterocyclic Derivatives (Synthesis, Spectral Identification, Microbial Evaluation). International Journal of Pharmaceutical Research. 2021; 13(1): 4234-4242.
54. Nor A., Sad S., Nagham Mahmood Aljamali. Synthesis, Characterization and Thermal Analysis for New Amoxil Ligands. Asian Journal of Chemistry. 2019; 31(5): 1022-1026.
55. Rajaa Abdul Ameer Ghafil, Nor A Alrb, Nagham Mahmood Aljamali. Synthesis of Triazole Derivatives via Multi Components Reaction and Studying of (Organic Characterization, Chromatographic Behavior, Chem-Physical Properties). Egypt. J. Chem. 2020; 63(11):4163-4174. DOI: 10.21608/EJCHEM.2020.23541.2399.
56. Aljamali NM. Review in azo compounds and its biological activity. Biochem Anal Biochem. 2015; 4(2):1-4. doi:10.4172/2161-1009.1000169.
57. F. Jawad, Nagham Mahmood Aljamali. Preparation, Investigation and Study of Biological Applications of Tyrosine Derivatives against Breast Cancer Cells. NeuroQuantology. 2021; 19 (9): 117-125, doi: 10.14704/nq.2021.19.9.NQ21144.
58. Aljamali NM, Jawad SF. Preparation, Diagnosis and Evaluation of Cyclic-Tryptophan Derivatives as Anti Breast Cancer Agents. Biomedical and Pharmacology Journal. 2021;14(4):1983-1991. Available from: https://bit.ly/3HuvlVG.
59. Bishop C, Hudson VM, Hilton SC, et.al. A pilot study of the effect of inhaled buffered reduced glutathione on the clinical status of patients with cystic fibrosis. Chest. 2005 Jan 1;127(1):308-317. doi:10.1378/chest .127.1 .308. PMID 15653998.
60. Mandal PK, Tripathi M, Sugunan S. Brain oxidative stress: detection and mapping of anti-oxidant marker ‘Glutathione’ in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy. Biochemical and Biophysical Research Communications. 2012; 417(1): 43–48. doi:10.1016/j.bbrc.2011.11.047. PMID 22120629.


Regular Issue Open Access Article
Volume 7
Issue 2
Received December 9, 2021
Accepted December 27, 2021
Published December 31, 2021