[{“box”:0,”content”:”
n
n
- n t
n
USHAA ESWARAN, Vishal Eswaran
[/foreach]
n
n
n
- [foreach 286] [if 1175 not_equal=””]n t
- Principal and Professor, Senior Data Engineer, Department of ECE, Indira Institute of Technology and Sciences, Markapur,, CVS Health Centre, Dallas, Andhra Pradesh, Texas, India, United States
n[/if 1175][/foreach]
n
Abstract
nThis comprehensive review examines the critical importance of instrumentation and measurement technologies in enabling advances across diverse domains of modern biotechnology. Detailed examples are provided demonstrating how analytical tools empower quantitative biology, drive discoveries, catalyze innovations, and provide solutions to global challenges. The historical evolution of bioanalytical techniques is traced, highlighting milestones that unleashed new capabilities. Current trends and future outlook are explored, underscoring the ongoing pivotal need for precision measurement capabilities to continue pushing frontiers of biotechnology forward.
n
Keywords: Biotechnology, Instrumentation, Measurement Technologies, Analytical Techniques, Genomics, Single-Cell Analysis, Biosensors, Microfluidics, Synthetic Biology, Molecular Engineering, Point-Of-Care Diagnostics, Wearable Sensors, AI Integration, Automation, Emerging Trends.
n[if 424 equals=”Regular Issue”][This article belongs to International Journal of Molecular Biotechnological Research(ijmbr)]
n
n
n
n
n
nn
nn[if 992 equals=”Open Access”] Full Text PDF[else] nvar fieldValue = “[user_role]”;nif (fieldValue == ‘indexingbodies’) {n document.write(‘Full Text PDF‘);n }nelse if (fieldValue == ‘administrator’) { document.write(‘Full Text PDF‘); }nelse if (fieldValue == ‘ijmbr’) { document.write(‘Full Text PDF‘); }n else { document.write(‘ ‘); }n [/if 992] [if 379 not_equal=””]nn
Browse Figures
n
n[/if 379]n
References
n[if 1104 equals=””]n
- Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (2017). Molecular Biology of the Cell (6th ed.). Garland Science.
- Arugula, M. A., & Simonian, A. L. (2016). Recent advances in aptasensors for biomedical applications. ACS Applied Bio Materials, 2(4), 1613-1631.
- Bendall, S. C., Davis, K. L., Amir, E. D., Tadmor, M. D., Simonds, E. F., Chen, T. J., … & Nolan, G. P. (2011). Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development. Cell, 157(3), 714-725.
- Bolbat, A., & Liedert, C. (2020). Microfluidic-based microsystems for high-throughput bioprocess development. Engineering in Life Sciences, 20(5), 189-201.
- D’Orazio, P. (2013). Biosensors in clinical chemistry–2011 update. Clinica Chimica Acta, 412(15-16), 1749-1761.
- Gillet, L. C., Navarro, P., Tate, S., Röst, H., Selevsek, N., Reiter, L., … & Aebersold, R. (2012). Targeted data extraction of the MS/MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis. Molecular & Cellular Proteomics, 11(6), O111-016717.
- Hossain, M. A., Brennan, C. S., & Islam, N. (2014). Glucose biosensors: The journey so far and the path ahead. Sensors, 14(12), 21129-21154.
- Horváth, C., & Preiss, B. (1995). High-performance liquid chromatography: A practical guide. Springer Science & Business Media.
- Jiang, Y., Li, Y., & Liu, X. (2019). Nanomaterial-based biosensors for microbial detection. Microchimica Acta, 186(11), 730.
- Khalil, A. S., Lu, T. K., & Collins, J. J. (2010). Synthetic biology: Applications come of age. Nature Reviews Genetics, 11(5), 367-379.
- Lauffenburger, D. A., & Linderman, J. J. (1993). Receptors: models for binding, trafficking, and signaling. Oxford University Press.
- Mullis, K. B., Faloona, F. A., Scharf, S. J., Saiki, R. K., Horn, G. T., & Erlich, H. A. (1986). Specific enzymatic amplification of DNA in vitro: The polymerase chain reaction. Cold Spring Harbor Symposia on Quantitative Biology, 51, 263-273.
- Rajan, S., Zou, C., Leonardo, V., Daza, E. A., Buchovecky, C., Szpankowski, L., … & Heath, J. R. (2020). Multiplexed nanowire circuits for precision amplification of biomolecular signals. Nature Nanotechnology, 15(5), 451-458.
- Ruan, C., Shi, H., & Yu, H. Z. (2019). Biosensing: Bridging the gap between the laboratory and the field. Accounts of Chemical Research, 52(11), 3168-3177.
- Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., … & Arnheim, N. (1988). Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science, 239(4839), 487-491.
- Shendure, J., & Ji, H. (2008). Next-generation DNA sequencing. Nature biotechnology, 26(10), 1135-1145.
- Tang, X., He, Y., Tian, X., Wang, S., & Reed, S. (2015). Highly sensitive electrochemical detection of toxins: Impacts and challenges of nanomaterials. Nano Today, 10(6), 763-777.
- Varshney, R. K., Singh, V. K., & Börner, A. (2019). Genomics-assisted breeding for crop improvement. Trends in Plant Science, 24(11), 1151-1165.
- Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., … & Holt, R. A. (2001). The sequence of the human genome. Science, 291(5507), 1304-1351.
- Wang, Y., Navin, N. E., & Advances, A. (2019). Advances and applications of single-cell sequencing technologies. Molecular Cell, 58(4), 598-609.
nn[/if 1104][if 1104 not_equal=””]n
- [foreach 1102]n t
- [if 1106 equals=””], [/if 1106][if 1106 not_equal=””],[/if 1106]
n[/foreach]
n[/if 1104]
nn
nn[if 1114 equals=”Yes”]n
n[/if 1114]
n
n
n
International Journal of Molecular Biotechnological Research
n
n
n
n
n
n
| Volume | 01 |
| Issue | 02 |
| Received | August 24, 2023 |
| Accepted | September 16, 2023 |
| Published | November 28, 2023 |
n
n
n
n
n[/foreach]
n[/if 1190] [if 1177 not_equal=””]n
n
n[/foreach]
n[/if 1177]
n
n
n
n function myFunction2() {n var x = document.getElementById(“browsefigure”);n if (x.style.display === “block”) {n x.style.display = “none”;n }n else { x.style.display = “Block”; }n }n document.querySelector(“.prevBtn”).addEventListener(“click”, () => {n changeSlides(-1);n });n document.querySelector(“.nextBtn”).addEventListener(“click”, () => {n changeSlides(1);n });n var slideIndex = 1;n showSlides(slideIndex);n function changeSlides(n) {n showSlides((slideIndex += n));n }n function currentSlide(n) {n showSlides((slideIndex = n));n }n function showSlides(n) {n var i;n var slides = document.getElementsByClassName(“Slide”);n var dots = document.getElementsByClassName(“Navdot”);n if (n > slides.length) { slideIndex = 1; }n if (n (item.style.display = “none”));n Array.from(dots).forEach(n item => (item.className = item.className.replace(” selected”, “”))n );n slides[slideIndex – 1].style.display = “block”;n dots[slideIndex – 1].className += ” selected”;n }n n function myfun() {n x = document.getElementById(“editor”);n y = document.getElementById(“down”);n z = document.getElementById(“up”);n if (x.style.display == “none”) {n x.style.display = “block”;n }n else {n x.style.display = “none”;n }n if (y.style.display == “none”) {n y.style.display = “block”;n }n else {n y.style.display = “none”;n }n if (z.style.display == “none”) {n z.style.display = “block”;n }n else {n z.style.display = “none”;n }n }n function myfun2() {n x = document.getElementById(“reviewer”);n y = document.getElementById(“down2”);n z = document.getElementById(“up2”);n if (x.style.display == “none”) {n x.style.display = “block”;n }n else {n x.style.display = “none”;n }n if (y.style.display == “none”) {n y.style.display = “block”;n }n else {n y.style.display = “none”;n }n if (z.style.display == “none”) {n z.style.display = “block”;n }n else {n z.style.display = “none”;n }n }n”}]