Insilico Prediction of Multitarget Mechanism of Quinoline & Its Analogues on Phosphoinositide-3- Kinase Pathway Proteins

Year : 2023 | Volume : 01 | Issue : 01 | Page : 41-54
By

    Nyaipriya Devi Sanglakpam

  1. Student, B.Sc(Hons) Biotechnology, Ramaiah University of Applied Sciences, Mathikere, Karnataka, India

Abstract

Objective: Phosphoinositide 3-kinases (PI3Ks), the target of rapamycin (PI3K/Akt/mTOR, PAM, are a family of enzymes that play a role in the growth, proliferation, differentiation, motility, survival, and intracellular trafficking of cells, all of which are essential for healthy cellular function and are also connected to cancer. In this study, Quinoline and its derivatives were employed to analyse its inhibition activity on the phosphoinositide-3-kinase pathway. Methods: In this work, 8 phytocompounds from quinoline were chosen, and the PHOSPHOINOSITIDE-3-KINASE PATHWAY was analysed to assess their multitarget mechanism. The study was carried out computationally utilising PubChem as a data source and the molecular structures of the phytocompounds, as well as Indian medicinal plants, phytochemistry, and treatments. For the pharmacological evaluation of these drugs under the ADME properties for toxicity prediction, several additional approaches were applied. Results: The docking data revealed that eight analogues of quinoline were the most potent inhibitors for the proteins, Akt PBD 3MV5, PDK1 3RWQ, PIK3 3S2A and mTOR-4DRI. Conclusion: All of these bioactive compounds could be regarded as worthy candidates for the inhibition of the phosphoinositide-3-kinase pathway due to their high affinity for the protein.

Keywords: Phosphoinositide 3-kinase pathway, quinoline, 4DRI protein, 3MV5 protein, 3S2A protein, 3RWQ protein, multitarget mechanism.

[This article belongs to International Journal of Molecular Biotechnological Research(ijmbr)]

How to cite this article: Nyaipriya Devi Sanglakpam Insilico Prediction of Multitarget Mechanism of Quinoline & Its Analogues on Phosphoinositide-3- Kinase Pathway Proteins ijmbr 2023; 01:41-54
How to cite this URL: Nyaipriya Devi Sanglakpam Insilico Prediction of Multitarget Mechanism of Quinoline & Its Analogues on Phosphoinositide-3- Kinase Pathway Proteins ijmbr 2023 {cited 2023 Apr 20};01:41-54. Available from: https://journals.stmjournals.com/ijmbr/article=2023/view=106800

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Regular Issue Subscription Original Research
Volume 01
Issue 01
Received March 2, 2023
Accepted March 12, 2023
Published April 20, 2023