A Review of Different Polymer and Plasticizers

Year : 2024 | Volume :01 | Issue : 01 | Page : –

Gita Sahu

  1. Assistant Professor Department of Pharmacy, Gracious college of Pharmacy, Abhanpur, Raipur Chhattisgarh India


Plasticizer and polymer are essential components in the pharmaceutical industry, especially when creating both cutting-edge and conventional drug delivery systems. The differences between synthetic, semi-synthetic, and all-natural polymers are examined in this review to highlight their diverse qualities and uses. When designing drug delivery systems to target areas, the choice of polymer is crucial. Because of their repeatability and adaptability, synthetic polymers are widely used in the creation of precision medication delivery systems. Certain polymers, such poly (lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG), are well-known for their tunable characteristics and biocompatibility, which makes them appropriate for targeted drug release. Semi-synthetic polymers, on the other hand, provide a medium between regulated drug release and biodegradability, bridging the gap between natural and fully synthetic materials. This class of cellulose derivatives includes, for example, hydroxypropyl methylcellulose (HPMC), which is helpful in the formulation of medications with a variety of release characteristics. Plasticizers are an essential component that is used for coating tablets and maintaining medication release. They ensure the best possible medication delivery by improving the polymeric coatings’ flexibility and durability. Common plasticizers that affect the final dosage form’s mechanical and release qualities are triethyl citrate (TEC) and dibutyl phthalate (DBP). The usage of polymers and plasticizers has several disadvantages notwithstanding their benefits. Drug stability or efficacy may be changed by interactions between polymers and pharmaceuticals. Furthermore, some plasticizers may show signs of toxicity, which means that pharmaceutical formulations must undergo careful testing and adhere to regulations. The discovery of novel pharmacological remedies is the aim of this comprehensive study. Through clarifying the fundamental properties of polymers, classifying different kinds, and describing the roles of plasticizers, scientists may better customise drug delivery systems. The assessment highlights the significance of giving considerable thought and optimisation to reduce harmful effects while addressing potential issues.

Keywords: Polymer, Plasticizers, Natural, Synthetic, PVP, GA

[This article belongs to International Journal of Membranes(ijm)]

How to cite this article: Gita Sahu. A Review of Different Polymer and Plasticizers. International Journal of Membranes. 2024; 01(01):-.
How to cite this URL: Gita Sahu. A Review of Different Polymer and Plasticizers. International Journal of Membranes. 2024; 01(01):-. Available from: https://journals.stmjournals.com/ijm/article=2024/view=147790


  1. Srivastava A, Yadav T, Sharma S, Nayak A, Kumari AA, Mishra N. Polymers in drug delivery. Journal of Biosciences and Medicines. 2015 Dec 25;4(1):69-84.
  2. Jawahar N, Meyyanathan S. Polymeric nanoparticles for drug delivery and targeting: A comprehensive review. International Journal of Health & Allied Sciences. 2012 Oct 1;1(4):217-.
  3. Shaik MR, Korsapati M, Panati D. Polymers in controlled drug delivery systems. International journal of pharma sciences. 2012 Nov;2(4):112-6.
  4. Yang WW, Pierstorff E. Reservoir-based polymer drug delivery systems. Journal of laboratory automation. 2012 Feb;17(1):50-8.
  5. Srikanth, P., Raju, N., Raja, S.W. and Raj, S.B. (2013) A Review on Oral Controlled Drug Delivery. International Journal of Advanced Pharmaceutics, 3, 51-58.
  6. Kim KK, Pack DW. Microspheres for drug delivery.BioMEMS and Biomedical Nanotechnology: Volume I Biological and Biomedical Nanotechnology. 2006:19-50.
  7. Hoare TR, Kohane DS. Hydrogels in drug delivery: Progress and challenges. polymer. 2008 Apr 15;49(8):1993-2007.
  8. George PM, LaVan DA, Burdick JA, Chen CY, Liang E, Langer R. Electrically controlled drug delivery from biotin-doped conductive polypyrrole. Advanced Materials. 2006 Mar 3;18(5):577-81.
  9. Patel VF, Liu F, Brown MB. Advances in oral transmucosal drug delivery. Journal of controlled release. 2011 Jul 30;153(2):106-16.
  10. Sutradhar KB, Amin ML. Nanotechnology in cancer drug delivery and selective targeting. International scholarly research notices. 2014;2014.
  11. Park JH, Allen MG, Prausnitz MR. Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. Journal of controlled release. 2005 May 5;104(1):51-66.
  12. Lee JH, Nan A. Combination drug delivery approaches in metastatic breast cancer. Journal of drug delivery. 2012;2012.
  13. Srikanth Reddy J. Formulation and In-Vitro Evaluation of 5-Fluorouracil Microcapsules by using Different Methods of Microencapsulation (Doctoral dissertation, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamil Nadu, India).
  14. Deb J, Das M, Das A. Excellency of natural polymer in drug delivery system: A Review. IJPBA. 2017;5:17-22.
  15. Liechty WB, Kryscio DR, Slaughter BV, Peppas NA. Polymers for drug delivery systems. Annual review of chemical and biomolecular engineering. 2010 Jul 15;1:149-73.

Regular Issue Subscription Review Article
Volume 01
Issue 01
Received March 2, 2024
Accepted May 21, 2024
Published May 27, 2024