Comprehensive Overview of Carbohydrate Polymers

Year : 2024 | Volume :01 | Issue : 01 | Page : –

Mr.Harshal K Patil

  1. Student,Department of Pharmaceutics P S G V P M `s College of Pharmacy, Shahada, Nandurbar Maharashtra India


Targeting drug delivery specifically to the colon has become increasingly crucial for treating various colonic diseases like colorectal cancer, amebiasis, ulcerative colitis, and Crohn’s disease. Numerous strategies have been developed for this purpose, including using enzymatically degradable polymers, employing prodrug-based approaches, coating drugs with polymers sensitive to time or pH changes, utilizing osmotically and pressure-controlled delivery systems. Polysaccharides activated by the colon’s physiological environment show significant potential as they offer enhanced site specificity and address therapeutic requirements effectively. However, delivery systems relying solely on a single polysaccharide often fail to ensure precise targeted release due to variations in pH and transit time among individuals and disease states. Traditional methods often result in premature drug release. To overcome these challenges, combining or chemically modifying polysaccharides has been explored, effectively mitigating the limitations associated with single polysaccharide use. This review explores emerging approaches in this field, reexamines current technologies, and outlines future developments.

Keywords: Colonic diseases, Targeted drug delivery, Enzymatically degradable polymers, Polysaccharides, Site specificity

[This article belongs to International Journal of Membranes(ijm)]

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  1. Huang S, Fu X. Naturally derived materials-based cell and drug delivery systems in skin regeneration. Journal of Controlled Release. 2010 Mar 3;142(2):149-59.
  2. Kopecek J. Biomaterials and drug delivery: past, present, and future. Molecular pharmaceutics. 2010 Aug 2;7(4):922-5.
  3. Nichifor M, Mocanu G. Polysaccharide-drug conjugates as controlled drug delivery systems.
  4. Jain SK, Jain A. Target-specific drug release to the colon. Expert Opinion on Drug Delivery. 2008 May 1;5(5):483-98.
  5. Shukla RK, Tiwari A. Carbohydrate molecules: an expanding horizon in drug delivery and biomedicine. Critical Reviews™ in Therapeutic Drug Carrier Systems. 2011;28(3).
  6. Miller MC, Klyosov A, Mayo KH. The α-galactomannan Davanat binds galectin-1 at a site different from the conventional galectin carbohydrate binding domain. Glycobiology. 2009 Sep 1;19(9):1034-45.
  7. Platt D, Klyosov AA, Zomer E. Development of a polysaccharide as a vehicle to improve the efficacy of chemotherapeutics.
  8. Abubaker Y, Perez R, Pike M, Zalupski M, Fuloria J. A Phase I trial of DAVANAT®, a galactose pronged polymannose co-administered with 5-fluorouracil, in patients with refractory solid tumors. InMeeting: Gastrointestinal cancers symposium session type and session title: Cancers of the colon and rectum–General poster session Abstract 2005 (No. 270).
  9. Roos AA, Edlund U, Sjoberg J, Albertsson AC, Stålbrand H. Protein release from galactoglucomannan hydrogels: influence of substitutions and enzymatic hydrolysis by β-mannanase. Biomacromolecules. 2008 Aug 11;9(8):2104-10.
  10. Jain A, Gupta Y, Jain SK. Perspectives of biodegradable natural polysaccharides for site-specific drug delivery to the colon. J Pharm Pharm Sci. 2007 Apr;10(1):86-128.
  11. Muhidinov Z, Bobokalonov J, Liu L, Fassihi R. A Kinetic Study of Poorly Water Soluble Drug Released from Pectin Microcapsules Using Diffusion/Dissolution Model. InACS Symposium Series 2008 Nov 7 (Vol. 992, pp. 193-208).
  12. Panos I, Acosta N, Heras A. New drug delivery systems based on chitosan. Current Drug Discovery Technologies. 2008 Dec 1;5(4):333-41.
  13. Rinaudo M. Chitin and chitosan: Properties and applications. Progress in polymer science. 2006 Jul 1;31(7):603-32.
  14. Larrosa M, Tomé-Carneiro J, Yáñez-Gascón MJ, Alcántara D, Selma MV, Beltrán D, García-Conesa MT, Urbán C, Lucas R, Tomás-Barberán F, Morales JC. Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. Journal of medicinal chemistry. 2010 Oct 28;53(20):7365-76.
  15. Shah N, Shah T, Amin A. Polysaccharides: a targeting strategy for colonic drug delivery. Expert opinion on drug delivery. 2011 Jun 1;8(6):779-96.
  16. Hu X, Jing X. Biodegradable amphiphilic polymer–drug conjugate micelles. Expert opinion on drug delivery. 2009 Oct 1;6(10):1079-90.
  17. Bassi P, Kaur G. pH modulation: a mechanism to obtain pH-independent drug release. Expert opinion on drug delivery. 2010 Jul 1;7(7):845-57.
  18. Mandal AS, Biswas N, Karim KM, Guha A, Chatterjee S, Behera M, Kuotsu K. Drug delivery system based on chronobiology—A review. Journal of controlled release. 2010 Nov 1;147(3):314-25.
  19. Al-Tabakha MM. HPMC capsules: current status and future prospects. Journal of Pharmacy & Pharmaceutical Sciences. 2010 Oct 14;13(3):428-42.
  20. Ugurlu T, Turkoglu M, Gurer US, Akarsu BG. Colonic delivery of compression coated nisin tablets using pectin/HPMC polymer mixture. European Journal of Pharmaceutics and Biopharmaceutics. 2007 Aug 1;67(1):202-10.
  21. Caraballo I. Factors affecting drug release from hydroxypropyl methylcellulose matrix systems in the light of classical and percolation theories. Expert Opinion on Drug Delivery. 2010 Nov 1;7(11):1291-301.
  22. Li CL, Martini LG, Ford JL, Roberts M. The use of hypromellose in oral drug delivery. Journal of pharmacy and pharmacology. 2005 May;57(5):533-46..
  23. Chaudhary A, Tiwari N, Jain V, Singh R. Microporous bilayer osmotic tablet for colon-specific delivery. European Journal of Pharmaceutics and Biopharmaceutics. 2011 May 1;78(1):134-40.
  24. Nunthanid J, Huanbutta K, Luangtana-Anan M, Sriamornsak P, Limmatvapirat S, Puttipipatkhachorn S. Development of time-, pH-, and enzyme-controlled colonic drug delivery using spray-dried chitosan acetate and hydroxypropyl methylcellulose. European Journal of Pharmaceutics and Biopharmaceutics. 2008 Feb 1;68(2):253-9.
  25. Ferrari PC, Oliveira GF, Chibebe FC, Evangelista RC. In vitro characterization of coevaporates containing chitosan for colonic drug delivery. Carbohydrate polymers. 2009 Oct 15;78(3):557-63.
  26. Hodges LA, Connolly SM, Band J, O’Mahony B, Ugurlu Tİ, Turkoglu M, Wilson CG, Stevens HN. Scintigraphic evaluation of colon targeting pectin–HPMC tablets in healthy volunteers. International journal of pharmaceutics. 2009 Mar 31;370(1-2):144-50.
  27. Mennini N, Furlanetto S, Cirri M, Mura P. Quality by design approach for developing chitosan-Ca-alginate microspheres for colon delivery of celecoxib-hydroxypropyl-β-cyclodextrin-PVP complex. European journal of Pharmaceutics and Biopharmaceutics. 2012 Jan 1;80(1):67-75.
  28. Freire C, Podczeck F, Ferreira D, Veiga F, Sousa J, Pena A. Assessment of the in-vivo drug release from pellets film-coated with a dispersion of high amylose starch and ethylcellulose for potential colon delivery. Journal of Pharmacy and Pharmacology. 2010 Jan;62(1):55-61.
  29. Witczak ZJ. Carbohydrate therapeutics: New developments and strategies.
  30. Karrout Y, Neut C, Wils D, Siepmann F, Deremaux L, Dubreuil L, Desreumaux P, Siepmann J. Colon targeting with bacteria-sensitive films adapted to the disease state. European Journal of Pharmaceutics and Biopharmaceutics. 2009 Sep 1;73(1):74-81.
  31. Karrout Y, Neut C, Wils D, Siepmann F, Deremaux L, Flament MP, Dubreuil L, Desreumaux P, Siepmann J. Novel polymeric film coatings for colon targeting: Drug release from coated pellets. European Journal of Pharmaceutical Sciences. 2009 Jun 28;37(3-4):427-33.
  32. Karrout Y, Neut C, Siepmann F, Wils D, Ravaux P, Deremaux L, Flament MP, Dubreuil L, Lemdani M, Desreumaux P, Siepmann J. Enzymatically degraded Eurylon 6 HP-PG: ethylcellulose film coatings for colon targeting in inflammatory bowel disease patients. Journal of Pharmacy and Pharmacology. 2010 Dec;62(12):1676-84.
  33. Ali Asghar LF, Azeemuddin M, Jain V, Chandran S. Design and in vitro evaluation of formulations with pH and transit time controlled sigmoidal release profile for colon-specific delivery. Drug Delivery. 2009 Aug 1;16(6):295-303.
  34. Bigucci F, Luppi B, Cerchiara T, Sorrenti M, Bettinetti G, Rodriguez L, Zecchi V. Chitosan/pectin polyelectrolyte complexes: Selection of suitable preparative conditions for colon-specific delivery of vancomycin. European journal of pharmaceutical sciences. 2008 Dec 18;35(5):435-41.
  35. Bigucci F, Luppi B, Monaco L, Cerchiara T, Zecchi V. Pectin-based microspheres for colon-specific delivery of vancomycin. Journal of Pharmacy and Pharmacology. 2009 Jan;61(1):41-6.
  36. Oliveira GF, Ferrari PC, Carvalho LQ, Evangelista RC. Chitosan–pectin multiparticulate systems associated with enteric polymers for colonic drug delivery. Carbohydrate polymers. 2010 Oct 15;82(3):1004-9.
  37. Haupt S, Zioni T, Gati I, Kleinstern J, Rubinstein A. Luminal delivery and dosing considerations of local celecoxib administration to colorectal cancer. European journal of pharmaceutical sciences. 2006 Jun 1;28(3):204-11.
  38. Ravi V, Siddaramaiah, Pramod Kumar TM. Influence of natural polymer coating on novel colon targeting drug delivery system. Journal of Materials Science: Materials in Medicine. 2008 May;19:2131-6.
  39. Tuğcu-Demiröz FA, Acartürk F, Takka SE. Investigation of colon-specific dosage forms of ondansetron prepared with natural polymers. Die Pharmazie-An International Journal of Pharmaceutical Sciences. 2006 Nov 1;61(11):916-9.
  40. Soni ML, Namdeo KP, Jain SK, Gupta M, Dangi JS, Kumar M, Dangi YS. pH-enzyme di-dependent chronotherapeutic drug delivery system of theophylline for nocturnal asthma. Chemical and Pharmaceutical Bulletin. 2011 Feb 1;59(2):191-5.
  41. Lin WC, Yu DG, Yang MC. pH-sensitive polyelectrolyte complex gel microspheres composed of chitosan/sodium tripolyphosphate/dextran sulfate: swelling kinetics and drug delivery properties. Colloids and surfaces B: Biointerfaces. 2005 Aug 1;44(2-3):143-51.
  42. Ji C, Xu H, Wu W. In vitro evaluation and pharmacokinetics in dogs of guar gum and Eudragit FS30D-coated colon-targeted pellets of indomethacin. Journal of drug targeting. 2007 Jan 1;15(2):123-31.
  43. Soni ML, Namdeo KP, Jain SK, Gupta M, Dangi JS, Kumar M, Dangi YS. pH-enzyme di-dependent chronotherapeutic drug delivery system of theophylline for nocturnal asthma. Chemical and Pharmaceutical Bulletin. 2011 Feb 1;59(2):191-5.
  44. Jain A, Jain SK, Ganesh N, Barve J, Beg AM. Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer. Nanomedicine: Nanotechnology, Biology and Medicine. 2010 Feb 1;6(1):179-90.
  45. Kotagale N, Maniyar M, Somvanshi S, Umekar M, Patel CJ. Eudragit-S, Eudragit-L and cellulose acetate phthalate coated polysaccharide tablets for colonic targeted delivery of azathioprine. Pharmaceutical development and technology. 2010 Aug 1;15(4):431-7.
  46. Jain V, Jain D, Singh R. Factors effecting the morphology of eudragit S-100 based microsponges bearing dicyclomine for colonic delivery. Journal of pharmaceutical sciences. 2011 Apr 1;100(4):1545-52.
  47. Ibekwe VC, Khela MK, Evans DF, Basit AW. A new concept in colonic drug targeting: a combined pH‐responsive and bacterially‐triggered drug delivery technology. Alimentary pharmacology & therapeutics. 2008 Oct;28(7):911-6.
  48. Onishi H, Oosegi T, Machida Y. Efficacy and toxicity of Eudragit-coated chitosan–succinyl-prednisolone conjugate microspheres using rats with 2, 4, 6-trinitrobenzenesulfonic acid-induced colitis. International journal of pharmaceutics. 2008 Jun 24;358(1-2):296-302.
  49. Dubey R, Dubey R, Omrey P, Vyas SP, Jain SK. Development and characterization of colon specific drug delivery system bearing 5-ASA and camylofine dihydrochloride for the treatment of ulcerative colitis. Journal of drug targeting. 2010 Sep 1;18(8):589-601.

Regular Issue Subscription Review Article
Volume 01
Issue 01
Received May 10, 2024
Accepted May 19, 2024
Published May 21, 2024