Pharmacological Management of Parkinson’s Disease: Current Therapies and Emerging Treatments

Year : 2023 | Volume : 01 | Issue : 01 | Page : 30-42
By

    Sheilina Choudhary

  1. Student, Department of Biotechnology, Shoolini University of Biotechnology and Management Sciences,, Himachal Pradesh, India

Abstract

Objective: Parkinson’s disease, behind Alzheimer’s, is the second most common neurodegenerative ailment and a major cause of neurological morbidity worldwide. Clinical diagnosis is made, and current management is limited to symptomatic treatments, with levodopa remaining the cornerstone of pharmaceutical therapy. In certain patient groups, deep brain stimulation of specific basal ganglia targets can provide significant clinical relief. There are currently no proven disease-modifying medicines in clinical use that can halt or reverse the underlying neurodegenerative process. Methods: In this investigation, target proteins were downloaded from the PDB and docked in Biovia. The ligands’ and standard medications’ binding affinity with each target protein was compared and assessed. Also, only 4 substances were choosen for SWISS-ADME final results. Results: The docking result revealed that the ligands selected have the best binding affinity with all the three target proteins. Conclusion: The ligands could potentially be used to treat Parkinson’s Disease in the future approaches for studying the urge ligands in vitro and in vivo analysis in order to create novel parkinson’s inhibitors.

Keywords: Parkinson’s Disease, Phytocompounds, Molecular docking, SWISS-ADMET analysis, Levodopa

[This article belongs to International Journal of Genetic Modifications and Recombinations(ijgmr)]

How to cite this article: Sheilina Choudhary Pharmacological Management of Parkinson’s Disease: Current Therapies and Emerging Treatments ijgmr 2023; 01:30-42
How to cite this URL: Sheilina Choudhary Pharmacological Management of Parkinson’s Disease: Current Therapies and Emerging Treatments ijgmr 2023 {cited 2023 May 18};01:30-42. Available from: https://journals.stmjournals.com/ijgmr/article=2023/view=111692

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Regular Issue Subscription Original Research
Volume 01
Issue 01
Received April 13, 2023
Accepted May 4, 2023
Published May 18, 2023