Importance of inflammatory marker ratio and lipid profile ratio in Acute Ischemic Stroke

Year : 2024 | Volume : | : | Page : –
By

Mathew John

  1. Scientist C Jubilee Centre for Medical Research, JMMC&RI, Thrissur Kerala India

Abstract

Background: Acute Ischemic Stroke is a chronic inflammatory disease that is projected to be one of the leading causes of mortality affecting millions of people globally. It is essential to study the Platelet lymphocyte ratio (PLR), Neutrophil lymphocyte ratio (NLR) ratios and C reactive protein (CRP) in impacting the inflammatory status during stroke. It is also important that altered lipid metabolism could influence the inflammatory conditions associated with AIS. Hence analysing the relevance of lipid ratio and inflammatory ratio in the context of AIS is important to understand the pathophysiology of disease.
Methodology: The blood was collected from the participants for biochemical and hematological analysis such as lipid profile, CRP and Complete blood count for the quantitation of NLR and PLR.Results:The groups involved in the study are AIS and healthy controls. The sample size for this study was n=151 in both AIS and control group .Inflammatory markers such as NLR, PLR, CRP and lipid profile ratio, TG/HDL-C and systolic & diastolic BPs where the parameters considered for comparison between control and AIS groups. The results revealed that there was significant differences in NLR, CRP, TG/HDL-C and BP between the study groups (p value<0.01). PLR value did not significantly altered between the groups (P=0.5).
Conclusion:The result showed that inflammatory markers, lipid profile and blood pressure play vital role in the occurrence of acute ischemic stroke.

Keywords: Inflammation, haematological, triglycerides, neutrophils, platelets

How to cite this article: Mathew John. Importance of inflammatory marker ratio and lipid profile ratio in Acute Ischemic Stroke. International Journal of Brain Sciences. 2024; ():-.
How to cite this URL: Mathew John. Importance of inflammatory marker ratio and lipid profile ratio in Acute Ischemic Stroke. International Journal of Brain Sciences. 2024; ():-. Available from: https://journals.stmjournals.com/ijbs/article=2024/view=144624


References

  1. YuetingLiu,et al. Non-traditional lipid profiles and the risk of stroke: A systematic review and meta-analysis,Nutrition, Metabolism and Cardiovascular Diseases.2023;33(4):698-714.
  2. Gąsecki, D., Kwarciany, M., Kowalczyk, K. et al. Blood Pressure Management in Acute Ischemic Stroke. Curr Hypertens Rep 23, 3 (2021). https://doi.org/10.1007/s11906-020-01120-7.
  3. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317–29.
  4. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581–7.
  5. Schuhmann MK, Stoll G, Bieber M, et al. CD84 links T cell and platelet activity in cerebral thrombo-inflammation in acute stroke. Circ Res. 2020;127(8):1023–35.
  6. Parikh NS, Merkler AE, Iadecola C. Inflammation, autoimmunity, infection, and stroke: epidemiology and lessons from therapeutic intervention. Stroke.2020;51(3):711–8.
  7. Stoll G, Nieswandt B. Thrombo-inflammation in acute ischaemic stroke-implications for treatment. Nat Rev Neurol. 2019;15(8):473–81.
  8. Dong X, Gao J, Zhang CY, Hayworth C, Frank M, Wang Z. Neutrophil membrane-derived nanovesicles alleviate inflammation to protect mouse brain injury from ischemic stroke. ACS Nano. 2019;13(2):1272–83.
  9. Zhu B, Pan Y, Jing J, et al. Neutrophil counts, neutrophil ratio, and new stroke in minor ischemic stroke or TIA. Neurology. 2018;90(21):e1870–8.
  10. Pengyu Gong, Yukai Liu, Yachi Gong, et al. The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in patients with acute ischemic stroke.Journal of Neuroinflammation ,2021.https://doi.org/10.1186/s12974-021-02090-6.
  11. Zahorec R. Neutrophil-to-lymphocyte ratio, past, present and future perspectives. Bratisl Lek Listy. 2021;122(7):474-488.
  12. Gasparyan AY, Ayvazyan L, Mukanova U, Yessirkepov M, Kitas GD.The platelet-to-lymphocyte ratio as an inflammatory marker in rheumatic diseases. Ann Lab Med. 2019;39: 345–357
  13. Goyal N, Tsivgoulis G, Chang JJ, et al. Admission neutrophil-to-lymphocyte ratio as a prognostic biomarker of outcomes in large vessel occlusion strokes. Stroke. 2018;49(8):1985–7.
  14. Curbelo J, Luquero Bueno S, Galván-Román JM, et al. Inflammation biomarkers in blood as mortality predictors in community-acquired pneumonia admitted patients: importance of comparison with neutrophil count percentage or neutrophil-lymphocyte ratio. Plos One. 2017;12(3):e0173947.
  15. SanossianNSaverJNavab M et al. High-density lipoprotein cholesterol: An emerging target for stroke treatment. Stroke. 2007; 38(3): 1104-1109.
  16. Qureshi AI, Ezzeddine MA, Nasar A, et al. Prevalence of elevated blood pressure in 563,704 adult patients with stroke presenting to the ED in the United States.Am J Emerg Med. 2007 Jan;25(1):32–8.
  17. Broderick J, Brott T, Barsan W, et al.Blood pressure during the first minutes of focal cerebral ischemia.Ann Emerg Med. 1993;22(9):1438–43.
  18. Leonardi-Bee J, Bath PMW, Phillips SJ, Sandercock PAG. Blood pressure and clinical outcomes in the international stroke trial. Stroke. 2002;33 (5):1315–20.
  19. Wohlfahrt P, Krajcoviechova A, Jozifova M, Mayer O, et al. Low blood pressure during the acute period of ischemic stroke is associated with decreased survival. J Hypertens.2015;33: 339–45.
  20. Arenillas JF, Cortijo E, Garcı P, et al. Relative cerebral blood volume is associated with collateral status and infarct growth in stroke patients in SWIFT PRIME. JCereb Blood Flow Metab. 2018;38(10):1839–1847.
  21. Puhr-Westerheide D, Tiedt S, Rotkopf LT, Herzberg M, Reidler P, Fabritius MP, et al. Clinical and imaging parameters associated with hyperacute infarction growth in large vessel occlusion stroke.Stroke. 2019;50:2799–804.
  22. Mechtouff L, Bochaton T, Paccalet A, Da Silva CC, Buisson M, Amaz C, et al. Matrix metalloproteinase-9 and monocyte chemoattractant protein-1 are associated with collateral status in acute ischemic stroke with large vessel occlusion. Stroke.2020;51:2232–5.
  23. Wufuer A, XiaoningZ.Blood pressure and collateral circulation in acute ischemic stroke. Herz.2019;44:455–9.
  24. Rusanen H, Saarinen T, Sillanpää N. The association of blood pressure and collateral circulation in hyperacute ischemic stroke patients treated with intravenous thrombolysis. Cerebrovasc Dis.2015;39:130–7.
  25. Jiang B, Churilov L, Kanesan L, Dowling R, Mitchell P, Dong Q.Blood pressure may be associated with arterial collateralization in anterior circulation ischemic stroke before acute reperfusion therapy.J Stroke. 2017;19(2):222–8.
  26. Raychev R, Liebeskind DS, Yoo AJ, Rasmussen M, ArnaudovD,Brown S, et al. Physiologic predictors of collateral circulation and infarct growth during anesthesia – detailed analyses of the GOLIATH trial. J Cereb Blood Flow Metab. 2020;40(6):1203–12.
  27. Christoforidis GA, Saadat N, Kontzialis M, Karakasis CJ, Slivka AP. Predictors for the extent of pial collateral recruitment in acute ischemic stroke. Neuroradiol J. 2020;33(2):98–104.
  28. Hong L, Cheng X, Lin L, Bivard A, Ling Y, Butcher K, et al. The blood pressure paradox in acute ischemic stroke. Ann Neurol.2019;85(3):331–9.
Ahead of Print Subscription Original Research
Volume
Received April 21, 2024
Accepted April 25, 2024
Published April 29, 2024
Views: 18