Tatapudi Sowjanya
Alladi Saritha
Abstract
In present study comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the preformulation studies E1 to E4 and S1 to S4 batches were prepared using selected polymers. Prepared microspheres were evaluated for the percentage yield, drug content, drug entrapment efficiency and in-vitro dissolution test. The data obtained from the In- vitro release showed highly correlated with Korsmeyer-Peppas model and Regression was found to be 0.9957 with 1.2 as a n value. The release kinetic study has shown that drug release from microspheres follows the Korsmeyer Peppas as the drug release occurs super case II transport with erosion. For optimised formulation the drug entrapment efficiency was 91.5%, Percentage yield was 77.3%, Drug content 85.7% Comparison was made between the best formulations E3 & S3 of microspheres prepared by using Ethyl cellulose as synthetic and Sodium alginate as natural polymers respectively. Among these formulations microspheres prepared by using ethyl cellulose as polymer found to be best formulation with highest drug content of 85.7%, entrapment efficiency of 91.5%, Percentage yield of 77.3% and in-vitro drug release 88.55% for 16 hours and ethyl cellulose polymers was found to be the best formulation for the preparation of novel drug delivery system for Levetiracetam. While control of drug release profile has been a major aim of pharmaceutical research and development of past decade, control of Gl transmit profile could be the focus of next few decades and might results in the availability of products with better therapeutic possibilities and substantial benefits for patients. Dosing frequency and loss of drug also reduced by the use of such type formulations and the bioavailability of drugs can also be increased. All the above studies reveal that the microsphere can serve as an ideal drug delivery system for Levetiracetam loaded microspheres. Further studies can be done on the stability on Levetiracetam loaded microspheres and the improvement in therapeutic efficacy due to the targeting effort on to the specific receptor sites.
Keywords: Formulation, Evaluation, Levetiracetam, Microspheres, Scanning electron Microscope.
[This article belongs to International Journal of Biomedical Innovations and Engineering(ijbie)]
References
. Reddy BV, Krishnaveni K. Formulation and evaluation of efavirenz microspheres. Der Pharmacia letters. 2015; 7(6):1-9.
- Thanoo BC, Sunny MC, Jayakrishnan A. Cross-linked chitosan microspheres: preparation and evaluation as a matrix for the controlled release of pharmaceuticals. Journal of pharmacy and pharmacology. 1992 Apr; 44(4):283-6.
- Sahil K, Akanksha M, Premjeet S, Bilandi A, Kapoor B. Microsphere: A review. Int. J. Res. Pharm. Chem. 2011;1(4):1184-98.
- Virmani T, Gupta J. Pharmaceutical application of microspheres: an approach for the treatment of various diseases. Int J Pharm Sci Res. 2017; 8(8):3253-60.
- Li SP, Kowarski CR, Feld KM, Grim WM. Recent advances in microencapsulation technology and equipment. Drug Development and Industrial Pharmacy. 1988 Jan 1; 14(2-3):353-76.
- Kreuter J, Nefzger M, Liehl E, CzokR VR. Microspheres–A Novel Approach in Drug Delivery System. J Pharm sci. 1983; 72:1146.
- Margel S, Wiesel E. Acrolein polymerization: monodisperse, homo, and hybrido microspheres, synthesis, mechanism, and reactions. Journal of Polymer Science: Polymer Chemistry Edition. 1984 Jan; 22(1):145-58.
- Wakiyama N, Juni K, Nakano M. Preparation and evaluation in vitro of polylactic acid microspheres containing local anesthetics. Chemical and Pharmaceutical Bulletin. 1981 Nov 25; 29(11):3363-8.
- Patel NR, Patel DA, Bharadia PD, Pandya V, Modi D. Microsphere as a novel drug delivery. International Journal of Pharmacy & Life Sciences. 2011 Aug 1; 2(8).
- Toshio Y, Mitsuru H, Shozo M, Hitoshi S. Specific delivery of mitomycin c to the liver, spleen and lung: Nano-and m1crospherical carriers of gelatin. International Journal of Pharmaceutics. 1981 Apr 1;8(2):131-41.
- Patel NR, Patel DA, Bharadia PD, Pandya V, Modi D. Microsphere as a novel drug delivery. International Journal of Pharmacy & Life Sciences. 2011 Aug 1;2(8).
- Herfarth H, Obermeier F, Andus T, Rogler G, Nikolaus S, Kuehbacher T, Schreiber S. Improvement of arthritis and arthralgia after treatment with infliximab (Remicade) in a German prospective, open-label, multicenter trial in refractory Crohn’s disease. The American journal of gastroenterology. 2002 Oct 1;97(10):2688.
- Kavita K, Ashvini VR, Ganesh NS. Albumin microspheres. Unique system as drug delivery carriers for non steroidal anti-inflammatory drugs. Int J Pharm Sci Rev Res. 2010; 5(2):10.
- Virmani T, Gupta J. Pharmaceutical application of microspheres: an approach for the treatment of various diseases. Int J Pharm Sci Res. 2017; 8(8):3253-60.
- Gullotti E, Yeo Y. Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery. Molecular pharmaceutics. 2009 Aug 3; 6(4):1041-51.
- Alagusundaram M, Chetty MS, Umashankari K, Badarinath AV, Lavanya C, Ramkanth S. Microspheres as a novel drug delivery system: A review. Int J Chem Tech Res. 2009 Jul; 1(3):526-34.
- Rathore B, Yadav A, Nayak G, Saraogi GK, Singhai AK. A review on microspheres as drug delivery carriers for management of diabetes mellitus. International journal of pharmacy & life sciences. 2012 Oct 1; 3(10).
- Prasad BS, Gupta VR, Devanna N, Jayasurya K. Microspheres as drug delivery system-a review. J Glob Trends Pharm Sci. 2014; 5(3):1961-72.
| Volume | 02 |
| Issue | 01 |
| Received | February 8, 2024 |
| Accepted | February 12, 2024 |
| Published | March 1, 2024 |