Harnessing the Medicinal Potential of SwertiaChirata: A Phytochemical Strategy for Controlling Coronavirus Symptoms Like High Fever and Anxiety

Year : 2024 | Volume :01 | Issue : 02 | Page : 27-31
By

DILIP THAKUR

Abstract

The current investigation focuses on exploring the therapeutic capacities of SwertiaChirata, colloquially known as Chirata, in managing the symptomatic displays of coronavirus infections. Chirata, a member of the Gentianaceae family, is a distinguished herb extensively used in Ayurvedic and Unani medicinal traditions, acknowledged for its myriad of healing qualities. In addition to its regular use in combating fever and loss of appetite, its prominent antioxidant traits position it as an integral part of various health-boosting tonics. Considering the symptomological parallelism between the effects of Chirata and the erratic feverish symptoms often detected in coronavirus patients, our study emphasizes the potentiality of the herb in handling these signs. This could offer a viable substitute, subsequently lowering the reliance on medications like paracetamol, typically linked to unfavorable outcomes. SwertiaChirata is home to a wide variety of biologically active substances like Xanthones, flavonoids, iridoids, glycosides, and triterpenoids. These components have exhibited significant biological activities, including antimicrobial, anti-inflammatory, anticarcinogenic, antioxidant, and hypoglycemic properties [1]. The therapeutic power of these secondary metabolites offers hopeful routes for managing coronavirus symptoms. The broad medicinal applications of Chirata, ranging from treating liver disorders, chronic fevers, and anemia in Ayurveda to serving as a tonic and anti-inflammatory agent in Unani medicine, validate the herb’s therapeutic flexibility. The presence of unique biologically active substances and a variety of minerals contribute to this wide array of healing properties. Moreover, Chirata has proven successful against both Gram-positive and Gram-negative bacteria, amplifying its significance in the modern healthcare scenario. The Quantitative Structure-Activity Relationship (QSAR) study related to immunity boosting is yet to be comprehensively studied, especially in regards to preventing coronavirus-like diseases. However, the identified traits of Chirata’s biologically active substances offer promising initial steps towards effective symptom management strategies. This investigation underscores the critical need to incorporate such powerful herbal remedies into conventional allopathic medicine, proposing a sustainable, efficacious strategy to strengthen our fight against the daunting threats presented by pandemics such as coronavirus

Keywords: SwertiaChirata, Chirata, Herbal Extract, Phytochemicals, Coronavirus, Symptom Management, Xanthones, Immunity Enhancement.

[This article belongs to International Journal of Biomedical Innovations and Engineering(ijbie)]

How to cite this article: DILIP THAKUR. Harnessing the Medicinal Potential of SwertiaChirata: A Phytochemical Strategy for Controlling Coronavirus Symptoms Like High Fever and Anxiety. International Journal of Biomedical Innovations and Engineering. 2023; 01(02):27-31.
How to cite this URL: DILIP THAKUR. Harnessing the Medicinal Potential of SwertiaChirata: A Phytochemical Strategy for Controlling Coronavirus Symptoms Like High Fever and Anxiety. International Journal of Biomedical Innovations and Engineering. 2023; 01(02):27-31. Available from: https://journals.stmjournals.com/ijbie/article=2023/view=137792





References

  1. Singh, A. K., Patel, P. K., Choudhury, A., Maity, S., & Dash, S. S. (2020). Recent progress in the druggability of plant-derived secoiridoid glycosides. European Journal of Medicinal Chemistry, 202, 112574. https://doi.org/10.1016/j.ejmech.2020.112574
  2. Rastogi, S., Pandey, D. M., &Rawat, A. K. S. (2016). Swertiachirata: a traditional herb and its medicinal uses. Journal of Pharmaceutical Sciences and Research, 8(1), 74-78. https://www.jpsr.pharmainfo.in/Documents/Volumes/vol8Issue01/jpsr08011618.pdf
  3. Chen, L., Hu, C., Hood, M., Zhang, X., Zhang, L., Kan, J., …& Tan, J. (2020). A novel combination of vitamin C, curcumin and glycyrrhizic acid potentially regulates immune and inflammatory response associated with coronavirus infections: A perspective from system biology analysis. Nutrients, 12(4), 1193. https://doi.org/10.3390/nu12041193
  4. Rajbhandari, M., Mentel, R., Jha, P. K., Chaudhary, R. P., Bhattarai, S., Gewali, M. B., …&Lindequist, U. (2007). Antiviral activity of some plants used in Nepalese traditional medicine. Evidence-Based Complementary and Alternative Medicine, 6(4), 517–522. https://doi.org/10.1093/ecam/nel103
  5. Raja, W., Majeed, R., Kang, I. J., Andrabi, S. M., John, R., Raja, I. A., & Mir, M. R. (2017). Flavonoids as prospective neuroprotectants and their therapeutic propensity in aging associated neurological disorders. Frontiers in Aging Neuroscience, 9, 218. https://doi.org/10.3389/fnagi.2017.00218
  6. Li, Z., Jiang, Y., Liu, T., Liu, M., & Xiao, S. (2016). Anti-inflammatory effects of a novel compound from Swertiachirata in rats. Pharmaceutical Biology, 54(6), 1001–1006. https://doi.org/10.3109/13880209.2015.1077453
  7. Kumar, V., Ahmed, D., Verma, A., Anwar, F., Ali, M., &Mujeeb, M. (2013). Anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of Melastomamalabathricum Linn. leaves in streptozotocin induced diabetic rats. BMC complementary and alternative medicine, 13, 222. https://doi.org/10.1186/1472-6882-13-222
  8. Pinto, M. M. M., Sousa, M. E., &Nascimento, M. S. J. (2005). Xanthone derivatives: new insights in biological activities. Current medicinal chemistry, 12(21), 2517–2538. https://doi.org/10.2174/092986705774370645
  9. Galochkina, A. V., Anikin, V. B., Babkin, V. A., Ostrouhova, L. A., &Zarubaev, V. V. (2016). Antiviral activity of saponin from Medicago sativa L. against the influenza A virus. Influenza and other respiratory viruses, 10(6), 497-503. https://doi.org/10.1111/irv.12387
  10. Srivastava, S., Mishra, G., Mehta, A., Singh, P., Kaur, P., Sharma, A., …& Pandey, R. (2016). In silico and in vivo anti-malarial studies of 18β glycyrrhetinic acid from Glycyrrhizaglabra. PloS one, 11(9), e0162900. https://doi.org/10.1371/journal.pone.0162900
  11. Jäger, A. K., Saaby, L. (2011). Flavonoids and the CNS. Molecules, 16(2), 1471-1485. https://doi.org/10.3390/molecules16021471

Regular Issue Subscription Original Research
Volume 01
Issue 02
Received November 4, 2023
Accepted November 8, 2023
Published November 28, 2023