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A Comparative Study of Atibalāmūla Kvātha and Bhūmyāmalakī Cūrṇa in the Management of Diabetic Sensory Polyneuropathy

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u00a0Gyanendra Kumar Gupta, Gagan Devi,

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nJanuary 24, 2023 at 7:15 am

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nAbstract

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Bhūmyāmalakī and atibalāmūla is being used in certain hospital since long time with satisfactory
results in the patients of diabetic sensory polyneuropathy. An observational study on the use of these
plants in diabetic polyneuropathy is published in a peer reviewed journal. Therefore it was selected to
evaluate the individual effect of bhūmyāmalakī and atibalāmūla in comparison with the combination
of both the drugs in the patients of diabetic sensory polyneuropathy.

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Volume :u00a0u00a08 | Issue :u00a0u00a03 | Received :u00a0u00a0August 2, 2021 | Accepted :u00a0u00a0October 19, 2021 | Published :u00a0u00a0November 7, 2021n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)] [/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue A Comparative Study of Atibalāmūla Kvātha and Bhūmyāmalakī Cūrṇa in the Management of Diabetic Sensory Polyneuropathy under section in Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)] [/if 424]
Keywords Bhūmyāmalakī, atibalāmūla, diabetic sensory polyneuropathy, drugs and obsevationalstudy

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References

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1. Patel K B, Patel M V, Gupta S N. Effect of atibalā and bhūmyāmalakī in 33 patients of diabetic
neuropathy. Ayu. 2011 Jul;32(3):353-6.
2. Lindsay Zilliox, et al. Treatment of diabetic sensory polyneuropathy. Curr Treat Options Neurol.
2011 Apr;13(2):143-59.
3. Agniveśa. Caraka saṁhitā with Vidyotini Hindi commentary by Shastri Kashinath, published by
Chaukhamba surbharati Academy, Varansi. Edition 14th.Nidan sthana. Pramehanidāna adhyāya.
Page no-4/47
4. Bhāv prakash.Nighntu. Guḍūcyādi varga, Page no-255
5. Agniveśa. Caraka saṁhitā with Vidyotini Hindi commentary by Shastri Kashinath, published by
Chaukhamba surbharati Academy, Varansi. Edition 14th. Viman sthan. Rogabhiṣagjitīyam
adhyāya, Page no-8/139.
6. Agniveśa. Caraka saṁhitā with Vidyotini Hindi commentary by Shastri Kashinath, published by
Chaukhamba surbharati Academy, Varansi. Edition 14th. Sutra sthana. ṣhadvirecanaśatīyo
adhyāya Page no-4/36.
7. Agniveśa. Caraka saṁhitā with Vidyotini Hindi commentary by Shastri Kashinath, published by
Chaukhamba surbharati Academy, Varansi. Edition 14th. Chikitsa sthana. Hikkāśvāsa cikitsitam
adhyāya 17/102,123,130,142,kāsa chiktsitam adhyāya Page no-18/40,
8. Agniveśa. Caraka saṁhitā with Vidyotini Hindi commentary by Shastri Kashinath, published by
Chaukhamba surbharati Academy, Varansi. Edition 14th., chikitsa sthana Rasāyana adhyāya,
Abayāmalakiya pāda Page no-1/63
9. Yogaratnākara with Vidhyotinī hindi commentary by vd. Lakshmipati Shastri, Chaukhamba
prakashan,Varanasi, ed. Reprint 2012 Uttarārdha, premeha nidāna pg-85
10. Suśruta. Yadavaji Trikamji Ācārya, Suśrutasaṁhitā. 7th ed. Varanasi: Chaukhambha Orientalia;
re-print 2003. Chikitsa sthana. Sarvopaghātaśamanīyarasāyana adhyāya Page no-27/10

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[if 424 not_equal=”Regular Issue”] Regular Issue[/if 424] Open Access Article

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Research & Reviews: A Journal of Drug Design & Discovery

ISSN: 2349-9036

Editors Overview

rrjoddd maintains an Editorial Board of practicing researchers from around the world, to ensure manuscripts are handled by editors who are experts in the field of study.

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    By  [foreach 286]n

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    Gyanendra Kumar Gupta, Gagan Devi

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  1. Professor & Head, Assistant Professor,Department of Physiology,RK Institute of Ayurvedic Medical Science Dewrania,Bareilly, Department of Anatomy, RK Institute of Ayurvedic Medical Science Dewrania, Bareilly,,Uttar Pradesh, Uttar Pradesh,India, India

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Abstract

nBhūmyāmalakī and atibalāmūla is being used in certain hospital since long time with satisfactory
results in the patients of diabetic sensory polyneuropathy. An observational study on the use of these
plants in diabetic polyneuropathy is published in a peer reviewed journal. Therefore it was selected to
evaluate the individual effect of bhūmyāmalakī and atibalāmūla in comparison with the combination
of both the drugs in the patients of diabetic sensory polyneuropathy.n

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Keywords: Bhūmyāmalakī, atibalāmūla, diabetic sensory polyneuropathy, drugs and obsevationalstudy

n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)]

n[/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue under section in Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)] [/if 424]

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References

n[if 1104 equals=””]

1. Patel K B, Patel M V, Gupta S N. Effect of atibalā and bhūmyāmalakī in 33 patients of diabetic
neuropathy. Ayu. 2011 Jul;32(3):353-6.
2. Lindsay Zilliox, et al. Treatment of diabetic sensory polyneuropathy. Curr Treat Options Neurol.
2011 Apr;13(2):143-59.
3. Agniveśa. Caraka saṁhitā with Vidyotini Hindi commentary by Shastri Kashinath, published by
Chaukhamba surbharati Academy, Varansi. Edition 14th.Nidan sthana. Pramehanidāna adhyāya.
Page no-4/47
4. Bhāv prakash.Nighntu. Guḍūcyādi varga, Page no-255
5. Agniveśa. Caraka saṁhitā with Vidyotini Hindi commentary by Shastri Kashinath, published by
Chaukhamba surbharati Academy, Varansi. Edition 14th. Viman sthan. Rogabhiṣagjitīyam
adhyāya, Page no-8/139.
6. Agniveśa. Caraka saṁhitā with Vidyotini Hindi commentary by Shastri Kashinath, published by
Chaukhamba surbharati Academy, Varansi. Edition 14th. Sutra sthana. ṣhadvirecanaśatīyo
adhyāya Page no-4/36.
7. Agniveśa. Caraka saṁhitā with Vidyotini Hindi commentary by Shastri Kashinath, published by
Chaukhamba surbharati Academy, Varansi. Edition 14th. Chikitsa sthana. Hikkāśvāsa cikitsitam
adhyāya 17/102,123,130,142,kāsa chiktsitam adhyāya Page no-18/40,
8. Agniveśa. Caraka saṁhitā with Vidyotini Hindi commentary by Shastri Kashinath, published by
Chaukhamba surbharati Academy, Varansi. Edition 14th., chikitsa sthana Rasāyana adhyāya,
Abayāmalakiya pāda Page no-1/63
9. Yogaratnākara with Vidhyotinī hindi commentary by vd. Lakshmipati Shastri, Chaukhamba
prakashan,Varanasi, ed. Reprint 2012 Uttarārdha, premeha nidāna pg-85
10. Suśruta. Yadavaji Trikamji Ācārya, Suśrutasaṁhitā. 7th ed. Varanasi: Chaukhambha Orientalia;
re-print 2003. Chikitsa sthana. Sarvopaghātaśamanīyarasāyana adhyāya Page no-27/10

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Regular Issue Open Access Article

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Research & Reviews: A Journal of Drug Design & Discovery

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[if 344 not_equal=””]ISSN: 2349-9036[/if 344]

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Volume 8
Issue 3
Received August 2, 2021
Accepted October 19, 2021
Published November 7, 2021

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Views: 1,270

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Reviewer

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Read More
RRJoDDD

Pharmacognosy and Phytochemical Study of Guduchi

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By [foreach 286]u00a0

u00a0Gyanendra Kumar Gupta, Gagan Devi,

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nJanuary 24, 2023 at 7:07 am

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nAbstract

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Guduchi is most easily and widely available drug with various positive health effect. It is difficult to obtain swarasa of Guduchi due to unavailability of fresh drug. Therefore, this study will focus to find
the possibilities of other dosage forms of Guduchi like kwatha and churna, where dry form is being
used.

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Volume :u00a0u00a08 | Issue :u00a0u00a02 | Received :u00a0u00a0July 10, 2021 | Accepted :u00a0u00a0August 20, 2021 | Published :u00a0u00a0August 30, 2021n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)] [/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue Pharmacognosy and Phytochemical Study of Guduchi under section in Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)] [/if 424]
Keywords Guduchi, Swarasa, Kwatha, Churna, drugs.

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References

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1. Practical pharmacognosy, 30th edition, by Dr. K.R. Khandelwal (Author).Nirali Prakashan.1
January 2008:3-5pp.
2. Laboratory guide for the analysis of Ayurveda and siddha formulations, Publisher: CCRAS-Ayush,
G S Lavekar; Ema Ema Pāḍhī; Pramila Pant; Central Council for Research in Ayurveda and Siddha
(India), Ministry of health and family welfare, govt. of India New Delhi.2010:27pp.
3. Gagandeep Kaur et al. Phytochemical and Biological Analysis of Tinospora cordifolia.
International Journal of Toxicological and Pharmacological Research 2016; 8(4); 297-305.
4. K. R. Khandelwal.Practical Pharmacognosy Techniques & Experiments. Nirali Prakashan .320pp.
5. K. R. Khandelwal.Practical Pharmacognosy Techniques & Experiments. Nirali Prakashan
.23.11pp.
6. Laboratory guide for the analysis of Ayurveda and siddha formulations, Publisher: CCRAS-Ayush,
G S Lavekar; Ema Ema Pāḍhī; Pramila Pant; Central Council for Research in Ayurveda and Siddha
(India), Ministry of health and family welfare, govt. of India New Delhi.2010:29-30pp.
7. K. R. Khandelwal. Practical Pharmacognosy Techniques & Experiments. Nirali Prakashan .23.8pp.
8. K. R. Khandelwal.Practical Pharmacognosy Techniques & Experiments. Nirali Prakashan .23.9 pp.
9. K. R. Khandelwal.Practical Pharmacognosy Techniques & Experiments. Nirali Prakashan .23.10
pp.
10. Laboratory guide for the analysis of Ayurveda and siddha formulations, Publisher: CCRAS-Ayush,
G S Lavekar; Ema Ema Pāḍhī; Pramila Pant; Central Council for Research in Ayurveda and Siddha
(India), Ministry of health and family welfare, govt. of India New Delhi.2010:83-87pp.

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n[/if 1114]

n

n

[if 424 not_equal=”Regular Issue”] Regular Issue[/if 424] Open Access Article

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Research & Reviews: A Journal of Drug Design & Discovery

ISSN: 2349-9036

Editors Overview

rrjoddd maintains an Editorial Board of practicing researchers from around the world, to ensure manuscripts are handled by editors who are experts in the field of study.

n

“},{“box”:4,”content”:”

n“},{“box”:1,”content”:”

    By  [foreach 286]n

  1. n

    Gyanendra Kumar Gupta, Gagan Devi

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    2. [/foreach]

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    [foreach 286] [if 1175 not_equal=””]n t

  1. Professor and HOD, Assistant Professor,Department of Kriya Sharir, SRS Ayurvedic Medical College, Department of Rachna Sharir, SRS Ayurvedic Medical College,Uttar Pradesh, Uttar Pradesh,India, India

    2. n[/if 1175][/foreach]

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Abstract

nGuduchi is most easily and widely available drug with various positive health effect. It is difficult to obtain swarasa of Guduchi due to unavailability of fresh drug. Therefore, this study will focus to find
the possibilities of other dosage forms of Guduchi like kwatha and churna, where dry form is being
used.n

n

n

Keywords: Guduchi, Swarasa, Kwatha, Churna, drugs.

n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)]

n[/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue under section in Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)] [/if 424]

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References

n[if 1104 equals=””]

1. Practical pharmacognosy, 30th edition, by Dr. K.R. Khandelwal (Author).Nirali Prakashan.1
January 2008:3-5pp.
2. Laboratory guide for the analysis of Ayurveda and siddha formulations, Publisher: CCRAS-Ayush,
G S Lavekar; Ema Ema Pāḍhī; Pramila Pant; Central Council for Research in Ayurveda and Siddha
(India), Ministry of health and family welfare, govt. of India New Delhi.2010:27pp.
3. Gagandeep Kaur et al. Phytochemical and Biological Analysis of Tinospora cordifolia.
International Journal of Toxicological and Pharmacological Research 2016; 8(4); 297-305.
4. K. R. Khandelwal.Practical Pharmacognosy Techniques & Experiments. Nirali Prakashan .320pp.
5. K. R. Khandelwal.Practical Pharmacognosy Techniques & Experiments. Nirali Prakashan
.23.11pp.
6. Laboratory guide for the analysis of Ayurveda and siddha formulations, Publisher: CCRAS-Ayush,
G S Lavekar; Ema Ema Pāḍhī; Pramila Pant; Central Council for Research in Ayurveda and Siddha
(India), Ministry of health and family welfare, govt. of India New Delhi.2010:29-30pp.
7. K. R. Khandelwal. Practical Pharmacognosy Techniques & Experiments. Nirali Prakashan .23.8pp.
8. K. R. Khandelwal.Practical Pharmacognosy Techniques & Experiments. Nirali Prakashan .23.9 pp.
9. K. R. Khandelwal.Practical Pharmacognosy Techniques & Experiments. Nirali Prakashan .23.10
pp.
10. Laboratory guide for the analysis of Ayurveda and siddha formulations, Publisher: CCRAS-Ayush,
G S Lavekar; Ema Ema Pāḍhī; Pramila Pant; Central Council for Research in Ayurveda and Siddha
(India), Ministry of health and family welfare, govt. of India New Delhi.2010:83-87pp.

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Regular Issue Open Access Article

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Research & Reviews: A Journal of Drug Design & Discovery

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[if 344 not_equal=””]ISSN: 2349-9036[/if 344]

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Volume 8
Issue 2
Received July 10, 2021
Accepted August 20, 2021
Published August 30, 2021

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Views: 1,306

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Editor

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Reviewer

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Read More
RRJoDDD

Distinctive Approaches for Improving the Aqueous Solubility of BCS Class II Drugs

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Article

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Views: 1,326

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By [foreach 286]u00a0

u00a0Panner Selvam R, Ganesh N.S, Prince Shukla, Vineeth Chandy,

[/foreach]
nJanuary 24, 2023 at 6:54 am

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nAbstract

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The most difficult feature of many novel chemical entities is their solubility behaviour, as 60 percent of new promising products suffer solubility limitations. This is the most common reason for novel medicine compounds failing to reach the market or performing to their full potential. The proportion of the aqueous phase when the solution is in equilibrium with the pure substance in its normal phase is referred to as aqueous solubility. The greatest dose strength of an immediate release medication is used to determine solubility. Physical and chemical alteration of the medication, as well as other strategies, has all been used to boost the solubility of poorly soluble drugs. The pharmacological qualities, absorption site, and desired dosage form characteristics all influence which solubility augmentation strategy is used. This review article examines various novel ways to improving the solubility of weakly water-soluble compounds.

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Volume :u00a0u00a08 | Issue :u00a0u00a03 | Received :u00a0u00a0August 27, 2021 | Accepted :u00a0u00a0October 27, 2021 | Published :u00a0u00a0November 10, 2021n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)] [/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue Distinctive Approaches for Improving the Aqueous Solubility of BCS Class II Drugs under section in Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)] [/if 424]
Keywords Solubility, poorly soluble, strategies, absorption

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References

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1. Surawase RK, Baheti1 BG, Maru AD. Solubility enhancement techniques for poorly water-
soluble drugs: a review. Eur J Bio Pharma Sci. 2020; 7(9): 124-36p.
2. Patel V, Patel R, Shah H, Purohit S, Pawar M, Pathan A. Solubility enhancement of azithromycin
by solid dispersion technique using Mannitol and β-Cyclodextrin. Acta Sci PharmaSci. 2021;
5(4): 48-54p.
3. Jagtap S, Magdum C, Jadge D, Jagtap R. Solubility Enhancement Technique: A Review. J Pharm
Sci & Res. 2018; 10(9): 2205-11p.
4. R Lobenberg, GL Amidon. Modern bioavailability, bioequivalence and biopharmaceutics
classification system. New scientific approaches to international regulatory standards. Eur J
Pharma Biopharma. 2000; 50(1): 3-12p.
5. Fouad SA, Malaak FA, El-Nabarawi MA, Zeid KA, Ghoneim AM. Preparation of solid dispersion
systems for enhanced dissolution of poorly water soluble diacerein: In-vitro evaluation,
optimization and physiologically based pharmacokinetic modeling. 2021; 16(1): 1-14p.
6. Sanjaymitra PVSS, Ganesh GNK. Dissolution and solubility enhancement strategies: current and
novel prospective. J Crit Rev. 2018; 5(3): 1-10p.
7. Gupta R, Jain V, Nagar JC, Ansari A, Sharma K, Sarkar A, Khan MS. Bioavailability
enhancement techniques for poorly soluble drugs: a review. Asian J Pharma Res Dev. 2020; 8(2):
75-78p
8. Alshehria S, Imama SS, Hussaina A. Potential of solid dispersions to enhance solubility,
bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer formulation
techniques, current marketed scenario and patents. Drug delivery. 2020; 27(1): 1625-43p
9. Huang S, Williams RO. Effects of process on the properties of amorphous solid dispersions.
AAPS PharmSciTech. 2018; 19(5): 1971-84p.
10. Tan K, DavisJr DA, Miller DA, Williams III RO, Nokhodchi A. Innovations in thermal
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new innovative technology: The Buchi nano spray dryer B 90. J Control Release. 2010; 147(2):
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14. Bala R, Madaan R, Arora S. Advanced solubility enhancement techniques for poorly soluble
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15. Adali MB, Barresi AA, Boccardo G, Pisano R. Spray freeze-drying as a solution to continuous
manufacturing of pharmaceutical products in bulk. Processes. 2020; 8(709): 1-27p.
16. Radke R, Jain NK. Melt sonocrystallization a novel technique of solubility enhancement: a
review. Int J Pharm Sci Rev Res. 2020; 64(2): 70-75p.
17. Sopan P, Nilesh M, Purushottam G, Amol W. Enhancement of solubility of diclofenac sodium by
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18. Pandit. PA, Chavan TT, Khandelwal RK. Oral lipid based multipurticulate pastilles: Design and
effect of pore former. J Pharma Invest. 2015; 45: 1-9p.
19. Thakur V, Dogra1 S, Verma S, Vashist HR. Solubility enhancement techniques. World J Pharma
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20. Gaddam M, Ravouru N. A Crystal engineering design to enhance the solubility, dissolution,
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21. Patel JN, Rathod DM, Patel NA, Modasiya MK. Techniques to improve the solubility of poorly
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22. Kumar RS, Sai JD. Liquisolid Compacts: A Review. J Drug Delivery & Thera. 2019; 9(4): 880-
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23. Xing H, Jiang J, Chen X, Yang T, Wang D, Ding P. Liquisolid technique and its applications in
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24. Savkare AD, Bhavsar MR, Gholap VD, Kukkar PM. Liquisolid technique: a review. Int J Pharma
Sci Res 2017; 8(7): 2768-75p.

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[if 424 not_equal=”Regular Issue”] Regular Issue[/if 424] Open Access Article

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Research & Reviews: A Journal of Drug Design & Discovery

ISSN: 2349-9036

Editors Overview

rrjoddd maintains an Editorial Board of practicing researchers from around the world, to ensure manuscripts are handled by editors who are experts in the field of study.

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    Panner Selvam R, Ganesh N.S, Prince Shukla, Vineeth Chandy

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  1. Associate Professor, Professor, Lecturer, Professor,Department of Pharmaceutics, T. John College of Pharmacy, Bengaluru, Department of Pharmaceutics, T. John College of Pharmacy, Bengaluru, Department of Pharmaceutical Chemistry, T. John College of Pharmacy, Bengaluru, r, Department of Pharmaceutical Chemistry, T. John College of Pharmacy, Bengaluru,Karnataka, Karnataka, Karnataka, Karnataka,India, India, India, India

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Abstract

nThe most difficult feature of many novel chemical entities is their solubility behaviour, as 60 percent of new promising products suffer solubility limitations. This is the most common reason for novel medicine compounds failing to reach the market or performing to their full potential. The proportion of the aqueous phase when the solution is in equilibrium with the pure substance in its normal phase is referred to as aqueous solubility. The greatest dose strength of an immediate release medication is used to determine solubility. Physical and chemical alteration of the medication, as well as other strategies, has all been used to boost the solubility of poorly soluble drugs. The pharmacological qualities, absorption site, and desired dosage form characteristics all influence which solubility augmentation strategy is used. This review article examines various novel ways to improving the solubility of weakly water-soluble compounds.n

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Keywords: Solubility, poorly soluble, strategies, absorption

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1. Surawase RK, Baheti1 BG, Maru AD. Solubility enhancement techniques for poorly water-
soluble drugs: a review. Eur J Bio Pharma Sci. 2020; 7(9): 124-36p.
2. Patel V, Patel R, Shah H, Purohit S, Pawar M, Pathan A. Solubility enhancement of azithromycin
by solid dispersion technique using Mannitol and β-Cyclodextrin. Acta Sci PharmaSci. 2021;
5(4): 48-54p.
3. Jagtap S, Magdum C, Jadge D, Jagtap R. Solubility Enhancement Technique: A Review. J Pharm
Sci & Res. 2018; 10(9): 2205-11p.
4. R Lobenberg, GL Amidon. Modern bioavailability, bioequivalence and biopharmaceutics
classification system. New scientific approaches to international regulatory standards. Eur J
Pharma Biopharma. 2000; 50(1): 3-12p.
5. Fouad SA, Malaak FA, El-Nabarawi MA, Zeid KA, Ghoneim AM. Preparation of solid dispersion
systems for enhanced dissolution of poorly water soluble diacerein: In-vitro evaluation,
optimization and physiologically based pharmacokinetic modeling. 2021; 16(1): 1-14p.
6. Sanjaymitra PVSS, Ganesh GNK. Dissolution and solubility enhancement strategies: current and
novel prospective. J Crit Rev. 2018; 5(3): 1-10p.
7. Gupta R, Jain V, Nagar JC, Ansari A, Sharma K, Sarkar A, Khan MS. Bioavailability
enhancement techniques for poorly soluble drugs: a review. Asian J Pharma Res Dev. 2020; 8(2):
75-78p
8. Alshehria S, Imama SS, Hussaina A. Potential of solid dispersions to enhance solubility,
bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer formulation
techniques, current marketed scenario and patents. Drug delivery. 2020; 27(1): 1625-43p
9. Huang S, Williams RO. Effects of process on the properties of amorphous solid dispersions.
AAPS PharmSciTech. 2018; 19(5): 1971-84p.
10. Tan K, DavisJr DA, Miller DA, Williams III RO, Nokhodchi A. Innovations in thermal
processing: hot-melt extrusion and kinetisol® dispersing deck. AAPS PharmSciTech. 2020;
21(312): 1-20p
11. Crowley MM, Zhang F, Repka MA, Thumma S, Upadhye SB, Kumar Battu S. Pharmaceutical
applications of hot-melt extrusion: part I. Drug Dev Ind Pharm. 2007; 33(9): 909-26p.
12. Li X, Anton N, Arpagaus C, Belleteix F, Vandamme TF. Nanoparticles by spray drying using
new innovative technology: The Buchi nano spray dryer B 90. J Control Release. 2010; 147(2):
304-10p.
13. Tripathi R, Biradar SV, Mishra B, Paradkar AR. Study of polymorphs of progesterone by novel
melt sonocrystallization technique: A technical note. AAPS Pharm Sci Tech. 2010; 11(3): 1493-
98p.
14. Bala R, Madaan R, Arora S. Advanced solubility enhancement techniques for poorly soluble
drugs. J Pharma Sci Tech. 2017; 7(1): 6-11p.
15. Adali MB, Barresi AA, Boccardo G, Pisano R. Spray freeze-drying as a solution to continuous
manufacturing of pharmaceutical products in bulk. Processes. 2020; 8(709): 1-27p.
16. Radke R, Jain NK. Melt sonocrystallization a novel technique of solubility enhancement: a
review. Int J Pharm Sci Rev Res. 2020; 64(2): 70-75p.
17. Sopan P, Nilesh M, Purushottam G, Amol W. Enhancement of solubility of diclofenac sodium by
pastillation method. J Drug Deli & Therap. 2021; 11(2): 6-10p.
18. Pandit. PA, Chavan TT, Khandelwal RK. Oral lipid based multipurticulate pastilles: Design and
effect of pore former. J Pharma Invest. 2015; 45: 1-9p.
19. Thakur V, Dogra1 S, Verma S, Vashist HR. Solubility enhancement techniques. World J Pharma
Res. 2020; 9(13): 265-82p.
20. Gaddam M, Ravouru N. A Crystal engineering design to enhance the solubility, dissolution,
stability and micromeritic properties of omeprazole via co-crystallization techniques. Research J.
Pharm. and Tech. 2021; 14(1): 356-62p.
21. Patel JN, Rathod DM, Patel NA, Modasiya MK. Techniques to improve the solubility of poorly
soluble drugs. Int J Pharm & Life Sci. 2012; 3(2): 1459-69p.
22. Kumar RS, Sai JD. Liquisolid Compacts: A Review. J Drug Delivery & Thera. 2019; 9(4): 880-
83p.
23. Xing H, Jiang J, Chen X, Yang T, Wang D, Ding P. Liquisolid technique and its applications in
pharmaceutics. Asian J Pharma Sci 2017; 12(2): 115-23p
24. Savkare AD, Bhavsar MR, Gholap VD, Kukkar PM. Liquisolid technique: a review. Int J Pharma
Sci Res 2017; 8(7): 2768-75p.

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Regular Issue Open Access Article

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Research & Reviews: A Journal of Drug Design & Discovery

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[if 344 not_equal=””]ISSN: 2349-9036[/if 344]

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Volume 8
Issue 3
Received August 27, 2021
Accepted October 27, 2021
Published November 10, 2021

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Views: 1,326

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RRJoDDD

A Review on Amino Acids

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u00a0Chandani Kamble, Rohankumar Chavan, Vikas Kamble,

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nJanuary 24, 2023 at 6:45 am

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nAbstract

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Protein is made up of amino acids, which are the building blocks of the molecule. Only 20 amino acids are involved in protein synthesis, even though more than 300 amino acids have been identified. In nature, all twenty amino acids did not appear at the same time. Rather, some of them appeared first, while others were later incorporated into the genetic code. It is vital to include them in one’s diet since a lack of them causes a reduction in protein synthesis, which leads to disease. In this article, amino acids, their properties, functions, and associated diseases have been elaborated.

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Volume :u00a0u00a08 | Issue :u00a0u00a03 | Received :u00a0u00a0September 17, 2021 | Accepted :u00a0u00a0September 21, 2021 | Published :u00a0u00a0November 10, 2021n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)] [/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue A Review on Amino Acids under section in Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)] [/if 424]
Keywords Amino acids, protein, activity, diseases

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References

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1. Satyanarayana U, Chakrapani U, Biochemistry, 4th Edn. Books & Allied Pvt. Ltd; 2013, 44-52.
2. Chatwal GR, Organic Chemistry of Natural Products, 1st Edn. Vol-I, Himalaya Publishing House,
2005, 2.1-2.13.
3. Agrawal OP, Organic Chemistry of Natural Products, 4th Edn. Vol-I, GOEL Publishing House;
2015, 122-137.
4. Deb AC, Fundamentals of Biochemistry, 10th Edn. New Central Book Agency (P) Ltd; 2016, 86.
5. Bahl A, Bahl AS, Advanced Organic Chemistry, 1st Edn. S. Chand and Company Pvt. Ltd; 1977,
854-868.
6. Agarkar P, Kulkarni Y, Biochemistry, 4th Edn. Nirali Prakashan; 2015, 2.1-2.7.
7. National Center for Biotechnology Information (2021). PubChem Compound Summary for CID
5950, Alanine. Retrieved August 12, 2021 from https://pubchem.ncbi.nlm.nih.gov/
compound/Alanine.
8. Donald AU, and Victor JH, A General Method for the Preparation of a-Labeled Amino Acids, J.
Org. Chem, 1977; Vol. 42: 13p.
9. KCAS. AMINO ACIDS. Available online at: https://kcasbio.com/compound-class/amino-acids/
10. Biochem. Amino acids – Proteins (Basic Overview). https://biochemden.com/amino-acids-
protein-fundamental-molecules/
11. Akram M, Asif HM, Uzair M. et.al. Amino acids: A review article, Journal of Medicinal Plants
Research,
9
September,
2011;
5(17):
3997-4000p,
Available
online
at
http://www.academicjournals.org/JMPR ISSN 1996-0875 ©2011 Academic Journals.
12. H.D. Belitz, H. D., Grosch, W., Schieberle, P., Amino Acids, Peptides, Proteins, December 2008
DOI: 10.1007/978-3-540-69934-7_2
13. Finar IL, Organic Chemistry: Stereochemistry & the Chemistry of Natural Product, 5th Edn. Vol-I,
Darling Kindersley (India) Pvt. Ltd; 2013, 652-669.
14. Scot R, Leonard S, New functions for amino acids: effects on gene transcription and translation,
Am. J. Clin. Nut, 2006; 83(2): 500-507p.
15. Théo Magrino, Fabio Pietrucci and A. Marco Saitta, Step by Step Strecker Amino Acid Synthesis
from Ab Initio Prebiotic Chemistry, J. Phys. Chem. Lett. 2021; 12(10): 2630–2637
16. Wu G. Amino acids: biochemistry and nutrition, Boca Raton (FL): CRC Press; 2013.
17. Hellwinkel D, Systematic Nomenclature of Organic Chemistry, Springer-Verlag, Berlin und
Heidelberg, Germany, 2001; 209-210p.
18. Wikipedia.
Amino
acid.
23
October
2021.
Available
online
at:
https://en.wikipedia.org/wiki/Amino_acid

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[if 424 not_equal=”Regular Issue”] Regular Issue[/if 424] Open Access Article

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Research & Reviews: A Journal of Drug Design & Discovery

ISSN: 2349-9036

Editors Overview

rrjoddd maintains an Editorial Board of practicing researchers from around the world, to ensure manuscripts are handled by editors who are experts in the field of study.

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    Chandani Kamble, Rohankumar Chavan, Vikas Kamble

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    2. [/foreach]

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  1. Student, Assistant Professor, Student,Department of Pharmaceutical Quality Assurance, Ashokrao Mane College of Pharmacy, Pethvadgaon, Kolhapur, Professor, Department of Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Department of Pharmacy, Adarsh Pharmacy College, Vita,Maharashtra, Maharashtra, Maharashtra,India, India, India

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Abstract

nProtein is made up of amino acids, which are the building blocks of the molecule. Only 20 amino acids are involved in protein synthesis, even though more than 300 amino acids have been identified. In nature, all twenty amino acids did not appear at the same time. Rather, some of them appeared first, while others were later incorporated into the genetic code. It is vital to include them in one’s diet since a lack of them causes a reduction in protein synthesis, which leads to disease. In this article, amino acids, their properties, functions, and associated diseases have been elaborated.n

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Keywords: Amino acids, protein, activity, diseases

n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)]

n[/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue under section in Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)] [/if 424]

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References

n[if 1104 equals=””]

1. Satyanarayana U, Chakrapani U, Biochemistry, 4th Edn. Books & Allied Pvt. Ltd; 2013, 44-52.
2. Chatwal GR, Organic Chemistry of Natural Products, 1st Edn. Vol-I, Himalaya Publishing House,
2005, 2.1-2.13.
3. Agrawal OP, Organic Chemistry of Natural Products, 4th Edn. Vol-I, GOEL Publishing House;
2015, 122-137.
4. Deb AC, Fundamentals of Biochemistry, 10th Edn. New Central Book Agency (P) Ltd; 2016, 86.
5. Bahl A, Bahl AS, Advanced Organic Chemistry, 1st Edn. S. Chand and Company Pvt. Ltd; 1977,
854-868.
6. Agarkar P, Kulkarni Y, Biochemistry, 4th Edn. Nirali Prakashan; 2015, 2.1-2.7.
7. National Center for Biotechnology Information (2021). PubChem Compound Summary for CID
5950, Alanine. Retrieved August 12, 2021 from https://pubchem.ncbi.nlm.nih.gov/
compound/Alanine.
8. Donald AU, and Victor JH, A General Method for the Preparation of a-Labeled Amino Acids, J.
Org. Chem, 1977; Vol. 42: 13p.
9. KCAS. AMINO ACIDS. Available online at: https://kcasbio.com/compound-class/amino-acids/
10. Biochem. Amino acids – Proteins (Basic Overview). https://biochemden.com/amino-acids-
protein-fundamental-molecules/
11. Akram M, Asif HM, Uzair M. et.al. Amino acids: A review article, Journal of Medicinal Plants
Research,
9
September,
2011;
5(17):
3997-4000p,
Available
online
at
http://www.academicjournals.org/JMPR ISSN 1996-0875 ©2011 Academic Journals.
12. H.D. Belitz, H. D., Grosch, W., Schieberle, P., Amino Acids, Peptides, Proteins, December 2008
DOI: 10.1007/978-3-540-69934-7_2
13. Finar IL, Organic Chemistry: Stereochemistry & the Chemistry of Natural Product, 5th Edn. Vol-I,
Darling Kindersley (India) Pvt. Ltd; 2013, 652-669.
14. Scot R, Leonard S, New functions for amino acids: effects on gene transcription and translation,
Am. J. Clin. Nut, 2006; 83(2): 500-507p.
15. Théo Magrino, Fabio Pietrucci and A. Marco Saitta, Step by Step Strecker Amino Acid Synthesis
from Ab Initio Prebiotic Chemistry, J. Phys. Chem. Lett. 2021; 12(10): 2630–2637
16. Wu G. Amino acids: biochemistry and nutrition, Boca Raton (FL): CRC Press; 2013.
17. Hellwinkel D, Systematic Nomenclature of Organic Chemistry, Springer-Verlag, Berlin und
Heidelberg, Germany, 2001; 209-210p.
18. Wikipedia.
Amino
acid.
23
October
2021.
Available
online
at:
https://en.wikipedia.org/wiki/Amino_acid

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Research & Reviews: A Journal of Drug Design & Discovery

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[if 344 not_equal=””]ISSN: 2349-9036[/if 344]

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Volume 8
Issue 3
Received September 17, 2021
Accepted September 21, 2021
Published November 10, 2021

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Views: 1,306

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