Examining Connective Tissue Changes Across Various Grades of Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: A Histochemical Polymeric Investigation

Open Access

Year : 2024 | Volume : | : | Page : –
By

Dr Fazilram P

Dr Uzma Belgaumi

Dr. Nupura Vibhute

Dr. Vidya Kadashetti

Dr. Wasim Kamate

Dr. Rashmi Gangavati

  1. PG student Dept. of Oral Pathology, School of Dental Sciences, Krishna Vishwa Vidyapeeth Deemed to be University, Karad Maharashtra India
  2. Associate Professor Dept. of Oral Pathology, School of Dental Sciences, Krishna Vishwa Vidyapeeth Deemed to be University, Karad Maharashtra India
  3. Professor & Head Dept. of Oral Pathology, School of Dental Sciences, Krishna Vishwa Vidyapeeth Deemed to be University, Karad Maharashtra India
  4. Associate Professor Dept. of Oral Pathology, School of Dental Sciences, Krishna Vishwa Vidyapeeth Deemed to be University, Karad Maharashtra India
  5. Assistant Professor Dept. of Oral Pathology, School of Dental Sciences, Krishna Vishwa Vidyapeeth Deemed to be University, Karad Maharashtra India
  6. Assistant Professor Dept. of Oral Pathology, School of Dental Sciences, Krishna Vishwa Vidyapeeth Deemed to be University, Karad Maharashtra India

Abstract

Oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) represent a spectrum of potentially malignant disorders posing significant challenges in diagnosis and management. The tumor microenvironment, particularly alterations in the connective tissue, plays a crucial role in the progression of these lesions. This histochemical investigation comprised with embedded polymers aimed to examine connective tissue changes across various grades of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). OED and OSCC represent a spectrum of potentially malignant disorders of the oral mucosa, with varying degrees of cellular and tissue alterations. However, the specific changes occurring in the connective tissue microenvironment across different grades of OED and OSCC remain poorly understood. In this study, histological sections from biopsied specimens of OED and OSCC were subjected to histochemical analysis to assess alterations in connective tissue components such as collagen fibers, mucins, and vascularization. Results revealed distinct patterns of connective tissue changes associated with different grades of OED and OSCC, highlighting the potential diagnostic and prognostic significance of these alterations in oral cancer progression through nanotechnological polymeric investigation.

Keywords: Oral epithelial dysplasia, histochemistry, oral cancer, potentially malignant disorders, Nanotechnology, Elastic fibres. Polymer, Nanoparticle.

How to cite this article: Dr Fazilram P, Dr Uzma Belgaumi, Dr. Nupura Vibhute, Dr. Vidya Kadashetti, Dr. Wasim Kamate, Dr. Rashmi Gangavati. Examining Connective Tissue Changes Across Various Grades of Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: A Histochemical Polymeric Investigation. Journal of Polymer and Composites. 2024; ():-.
How to cite this URL: Dr Fazilram P, Dr Uzma Belgaumi, Dr. Nupura Vibhute, Dr. Vidya Kadashetti, Dr. Wasim Kamate, Dr. Rashmi Gangavati. Examining Connective Tissue Changes Across Various Grades of Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: A Histochemical Polymeric Investigation. Journal of Polymer and Composites. 2024; ():-. Available from: https://journals.stmjournals.com/jopc/article=2024/view=156338

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Ahead of Print Open Access Original Research
Volume
Received February 8, 2024
Accepted May 16, 2024
Published June 8, 2024
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