Rakshana Manikandan,
M. Mala,
G. Manikandan,
Prakash Vaithyanathan,
- Trustee, Tagore Educational Trust, Chennai, Tamil Nadu, India
- Chairperson and Managing Trustee, Tagore Educational Trust, Chennai, Tamil Nadu, India
- Secretary, Tagore Educational Trust, Chennai, Tamil Nadu, India
- Science Teacher and Innovator, L.B road, Adyar, Chennai, Tamil Nadu, India
Abstract
Breach of association of legumain protein activities to the corresponding cellular components results in over-expression of legumain, and constitutes a key biomarker for a variety of life-threatening sicknesses like cancer, Alzheimer’s/Parkinson’s, and acute kidney injury. To suppress the over-expression of legumain, it is hypothesized that a water-soluble and edible biomolecule, namely, butrin (7, 3’, 4’-trihydroxy flavanone-7, 3’-diglucoside), may have therapeutic potential owing to its special ability to bind to the key catalytic sites of legumain, discovered through bioinformatic studies. Insights into the docking structure of butrin were provided with emphasis on the relative binding abilities of various hydroxyl groups of butrin with the amino acid residues of the legumain protein.
Keywords: Butrin, Legumain, molecular level interaction, biomarker, cancer tumor, Alzheimer’s disease, acute kidney injury
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References
- https://pubchem.ncbi.nlm.nih.gov/compound/Butrin
- Lal JB. Constitution of the Glucoside Butrin isolated from Butea Frondosa Flowers. Part I. J. Chem. Soc. 1937; 1562-64p.
- Dall E, randstetter H. Structure and function of legumain in health and disease. Biochimie. 2016; 122: 126-50p.
- Irfan N, Vaithyanathan P, Anandaram H, et al. Active and Allosteric Site Binding molecular mechanics-quantum mechanics studies of stevioside Derivative in PCSK9 Protein Intended to provide a safe Antilipidemic agent. bioRxiv preprint doi: https://doi.org/10.1101/2023.05.04.539221.
- Wang SS, Liu ZK, Liu JJ, et al. Imaging asparaginyl endopeptidase (AEP) in the live brain as a biomarker for Alzheimer’s disease. J Nanobiotechnol. 2021; 19:249.
- Tang Q, Xu F, Lin J, et al. Legumain affects the PI3K/AKT tumor progression pathway in retinoblastoma. Experimental Eye Research. 2022; 224:109221.
- Khan SU, Khan IM, Khan MU, et al. Role of LGMN in tumor development and its progression and connection with the tumor microenvironment. Front. Mol. Biosci. 10:1121964. doi: 10.3389/fmolb.2023.1121964.
- Elamin T, Brandstetter H, Dall E. Legumain Activity Is Controlled by Extended Active Site Residues and Substrate Conformation. Int. J. Mol. Sci. 2022; 23: 12548. https://doi.org/10.3390/ ijms232012548.
- Tu NH, Jense DD, Anderson BM, et al. Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2. The Journal of Neuroscience. 2021:41(1):193–210.
- Zahra N, Mazhar A, Zahid B, et al. Evaluation of influence of Butea monosperma floral extract on inflammatory biomarkers. Open Chemistry. 2024; 22: 20230199.
- Chen CA, Wang DK, Yu YY, et al. Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI. Cell Death and Disease. 2021; 12:65
| Volume | |
| Received | September 10, 2024 |
| Accepted | September 14, 2024 |
| Published | September 14, 2024 |