Noor O. Abdul-Kareem,
- Research Scholar University of Thi-Qar Nasiriyah Iraq
Abstract
Recent advancements in non-invasive Near-Infrared (NIR) spectroscopy techniques have significantly improved the detection and measurement of gout, a common form of inflammatory arthritis. Traditional diagnostic methods for gout, such as joint aspiration and crystal analysis, are invasive and can be uncomfortable for patients. In contrast, NIR spectroscopy offers a promising alternative by enabling real-time, non-invasive assessment of uric acid levels and related biomarkers associated with gout. The integration of portable NIR devices and advanced data analytics is paving the way for improved patient outcomes through more accessible and convenient diagnostic options. Spectroscopy and spectral sensing are employed in laboratories to identify and quantify various chemicals present in blood serum. Nevertheless, these techniques are primarily employed with extracted samples, such as blood and urine. This study aims to create a non-invasive method for measuring blood uric acid using a spectral sensor and spectroscopy. The Raspberry Pi 3 B+ is employed to convert the detected light intensity into the concentration of uric acid in this prototype. The light reflected on the individual’s wrist is quantified using a spectral sensor AS7263. The study’s limitations include using spectral sensors to detect light reflectance instead of blood uric acid concentration in mg/dL and relying on linear regression analysis to construct the conversion model. During testing, the prototype demonstrated an average percent difference of 6.61% from the uric acid meter, indicating that a spectral sensor can detect uric acid levels without requiring invasive procedures.
Keywords: NIR, Raspberry, Uric acid, spectroscopy, Spectral sensing device (SSD)
References
[1] Adomako E, Moe OW. Uric acid and urate in urolithiasis: the innocent bystander, instigator, and perpetrator. InSeminars in nephrology 2020 Nov 1 (Vol. 40, No. 6, pp. 564-573). WB Saunders. [2] Ye LW, Zhao L, Mei ZS, Zhou YH, Yu T. Association between periodontitis and uric acid levels in blood and oral fluids: a systematic review and meta-analysis. BMC oral health. 2023 Mar 28;23(1):178. [3] Liu G, Chen X, Lu X, Zhao J, Li X. Sunflower head enzymatic hydrolysate relives hyperuricemia by inhibiting crucial proteins (xanthine oxidase, adenosine deaminase, uric acid transporter1) and restoring gut microbiota in mice. Journal of Functional Foods. 2020 Sep 1;72:104055. [4] Mele C, Tagliaferri MA, Saraceno G, Mai S, Vietti R, Zavattaro M, Aimaretti G, Scacchi M, Marzullo P. Serum uric acid potentially links metabolic health to measures of fuel use in lean and obese individuals. Nutrition, Metabolism and Cardiovascular Diseases. 2018 Oct 1;28(10):1029-35. [5] Skoczyńska M, Chowaniec M, Szymczak A, Langner-Hetmańczuk A, Maciążek-Chyra B, Wiland P. Pathophysiology of hyperuricemia and its clinical significance–a narrative review. Reumatologia/Rheumatology. 2020 Oct 29;58(5):312-23. [6] Sanchez-Lozada LG, Rodriguez-Iturbe B, Kelley EE, Nakagawa T, Madero M, Feig DI, Borghi C, Piani F, Cara-Fuentes G, Bjornstad P, Lanaspa MA. Uric acid and hypertension: an update with recommendations. American journal of hypertension. 2020 Jul 18;33(7):583-94. [7] Ragab G, Elshahaly M, Bardin T. Gout: An old disease in new perspective–A review. Journal of advanced research. 2017 Sep 1;8(5):495-511. [8] Frąk W, Dąbek B, Balcerczyk-Lis M, Motor J, Radzioch E, Młynarska E, Rysz J, Franczyk B. Role of Uremic Toxins, Oxidative Stress, and Renal Fibrosis in Chronic Kidney Disease. Antioxidants. 2024 Jun 3;13(6):687. [9] Rodríguez-Iturbe B, García García G. The role of tubulointerstitial inflammation in the progression of chronic renal failure. Nephron Clinical Practice. 2010 Sep 1;116(2):c81-8. [10] Grande MT, Pérez-Barriocanal F, López-Novoa JM. Role of inflammation in tubulo-interstitial damage associated to obstructive nephropathy. Journal of inflammation. 2010 Dec;7:1-4. [11] Hayden MR, Tyagi SC. Uric acid: A new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttle. Nutrition & metabolism. 2004 Dec;1:1-5. [12] Kanbay M, Solak Y, Dogan E, Lanaspa MA, Covic A. Uric acid in hypertension and renal disease: the chicken or the egg. Blood purification. 2010 Nov 20;30(4):288-95. [13] Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. New England journal of medicine. 2008 Oct 23;359(17):1811-21. [14] Høieggen A, Alderman MH, Kjeldsen SE, Julius S, Devereux RB, De Faire U, Fyhrquist F, Ibsen H, Kristianson K, Lederballe-Pedersen O, Lindholm LH. The impact of serum uric acid on cardiovascular outcomes in the LIFE study. Kidney international. 2004 Mar 1;65(3):1041-9. [15] Viazzi F, Leoncini G, Ratto E, Pontremoli R. Serum uric acid as a risk factor for cardiovascular and renal disease: an old controversy revived. The Journal of Clinical Hypertension. 2006 Jul;8(7):510-8. [16] Nakagawa T, Mazzali M, Kang DH, Sánchez-Lozada LG, Herrera-Acosta J, Johnson RJ. Uric acid–a uremic toxin?. Blood purification. 2005 Dec 23;24(1):67-70. [17] De Smet R, Glorieux G, Hsu C, Vanholder R. p-Cresol and uric acid: two old uremic toxins revisited. Kidney international. Supplement. 1997 Nov;62:S8-11. [18] Perlstein TS, Gumieniak O, Hopkins PN, Murphey LJ, Brown NJ, Williams GH, Hollenberg NK, Fisher ND. Uric acid and the state of the intrarenal renin-angiotensin system in humans. Kidney international. 2004 Oct 1;66(4):1465-70. [19] Navaneethan SD, Beddhu S. Associations of serum uric acid with cardiovascular events and mortality in moderate chronic kidney disease. Nephrology Dialysis Transplantation. 2009 Apr 1;24(4):1260-6. [20] Asplin JR. Obesity and urolithiasis. Advances in chronic kidney disease. 2009 Jan 1;16(1):11-20. [21] Kanbay M, Sánchez-Lozada LG, Franco M, Madero M, Solak Y, Rodriguez-Iturbe B, Covic A, Johnson RJ. Microvascular disease and its role in the brain and cardiovascular system: a potential role for uric acid as a cardiorenal toxin. Nephrology Dialysis Transplantation. 2011 Feb 1;26(2):430-7. [22] Amarnani R, Shende P. Microneedles in diagnostic, treatment and theranostics: An advancement in minimally-invasive delivery system. Biomedical Microdevices. 2022 Mar;24(1):4. [23] Ashcheulova T. Evolution of examination methods in pulmonology, gastroenterology, and nephrology. (2014). [24] Du Rand IA, Barber PV, Goldring J, Lewis RA, Mandal S, Munavvar M, Rintoul RC, Shah PL, Singh S, Slade MG, Woolley A. British Thoracic Society guideline for advanced diagnostic and therapeutic flexible bronchoscopy in adults. Thorax. 2011 Nov 1;66(Suppl 3):iii1-21. [25] Anupongongarch P, Kaewgun T, O’Reilly JA, Khaomek P. A STUDY ON THE RELATION BETWEEN DIGITAL OUTPUT AND URIC ACID IN ARTIFICIAL BLOOD SOLUTION BY USING A URIC ACID DETECTOR. INTERNATIONAL JOURNAL OF APPLIED. 2022;15(2). [26] Forde DE. The Association of Kangaroo Mother Care, Energy Conservation, and Bonding in Preterm Neonates. University of San Diego; 2018. [27] Alam MZ, Hoque MR, Hu W, Barua Z. Factors influencing the adoption of mHealth services in a developing country: A patient-centric study. International journal of information management. 2020 Feb 1;50:128-43.
International Journal of Toxins and Toxics
Volume | |
Received | August 1, 2024 |
Accepted | August 14, 2024 |
Published | September 2, 2024 |