Nabiel Salam,
Prof Dr Ravi Kumar Chittoria,
Padmalakshmi Bharati Mohan,
Kanav Gupta,
Jacob Antony Chakiath,
- Junior Resident Department of Orthopedic Surgery Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry India
- Professor of Plastic Surgery & Registrar (Academic) Head of IT Wing and Telemedicine Department of Plastic Surgery & Telemedicine Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry India
- Assistant Professor Department of plastic surgery Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry India
- Senior Resident Department of Plastic Surgery Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry India
- Senior Resident Department of Plastic Surgery Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry India
Abstract
Advancements in wound healing have incorporated tissue regeneration therapy as a crucial tool for managing both acute and chronic wounds. Bio constructs designed to facilitate wound regeneration utilize natural, artificial, or hybrid materials, collectively referred to as regeneration scaffolds. The components of regeneration scaffolds play a crucial role in enhancing the skin’s natural self-renewal abilities and accelerating the healing process. These scaffolds are designed to provide essential growth factors and stem cells that stimulate cell proliferation and tissue repair. By creating an optimal environment for cellular activities, they help in quicker wound healing and tissue regeneration, leading to improved recovery outcomes. This advanced approach not only supports the body’s inherent healing mechanisms but also ensures more efficient and effective restoration of damaged skin. Scaffolds have played crucial roles in diverse medical and research contexts over an extended period. However, commercially available scaffolds are often prohibitively expensive, limiting their accessibility. To address this issue, an indigenous scaffold was developed using a combination of multiple components, including the amniotic membrane, collagen, and silicone. This new method aimed to produce a more affordable option without sacrificing standards of excellence. Through rigorous testing and evaluation, it was found that this indigenous scaffold performed on par with, and in some cases even surpassed, the commercially available options in terms of functionality and efficacy. This development not only offers a more affordable solution but also paves the way for wider use in medical and scientific fields.
Keywords: Regeneration scaffold; post burn raw area; dermal regeneration; regenerative therapy, indigenous scaffold, silicone, medical field
[This article belongs to Research & Reviews: A Journal of Health Professions(rrjohp)]
References
- Burke, J.F. et al. (1981) Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann. Surg. 194,413-428.
- Jones I, Currie L, Martin R. A guide to biological skin substitutes. British journal of plastic surgery. 2002 Apr 1;55(3):185-93.
- Shakespeare PG. The role of skin substitutes in the treatment of burn injuries. Clinics in dermatology. 2005 Jul 1;23(4):413-8.
- Augustine R, Kalarikkal N, Thomas S. Advancement of wound care from grafts to bioengineered smart skin substitutes. Progress in biomaterials. 2014 Dec;3:103-13.
- Nathoo R, Howe N, Cohen G. Skin substitutes: an overview of the key players in wound management. The Journal of clinical and aesthetic dermatology. 2014 Oct;7(10):44.
- Chevallay B, Herbage D. Collagen-based biomaterials as 3D scaffold for cell cultures: applications for tissue engineering and gene therapy. Medical and Biological Engineering and Computing. 2000 Mar;38:211-8.
- Stratton S, Shelke NB, Hoshino K, Rudraiah S, Kumbar SG. Bioactive polymeric scaffolds for tissue engineering. Bioactive materials. 2016 Dec 1;1(2):93-108.
- Nikolova MP, Chavali MS. Recent advances in biomaterials for 3D scaffolds: A review. Bioactive materials. 2019 Dec 1;4:271-92.
- Hutmacher DW, Goh JC, Teoh SH. An introduction to biodegradable materials for tissue engineering applications. Annals-academy of medicine singapore. 2001 Mar 1;30(2):183-91.
- Kim, B.S. and Mooney, D.J. (1998) Development of biocompatible synthetic extracellular matrices for tissue engineering. Trends Biotechnol. 16, 224-230.
- Kannan RY, Salacinski HJ, Ghanavi JE, Narula A, Odlyha M, Peirovi H, Butler PE, Seifalian AM. Silsesquioxane nanocomposites as tissue implants. Plastic and reconstructive surgery. 2007 May 1;119(6):1653-62.
- Vieira VJ, d’Acampora AJ, Marcos AB, Di Giunta G, de Vasconcellos ZA, Bins-Ely J, Neves RD, Figueiredo CP. Vascular endothelial growth factor overexpression positively modulates the characteristics of periprosthetic tissue of polyurethane-coated silicone breast implant in rats. Plastic and reconstructive surgery. 2010 Dec 1;126(6):1899-910.
- Kannan RY, Salacinski HJ, Sales KM, Butler PE, Seifalian AM. The endothelization of polyhedral oligomeric silsesquioxane nanocomposites: An in vitro study. Cell biochemistry and biophysics. 2006 Jun; 45:129-36.
- Bergmann PA, Tamouridis G, Lohmeyer JA, Mauss KL, Becker B, Knobloch J, Mailänder P, Siemers F. The effect of a bacterial contamination on the formation of capsular contracture with polyurethane breast implants in comparison with textured silicone implants: an animal study. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2014 Oct 1;67(10):1364-70.
- Copeland M, Choi M, Bleiweiss IJ. Silicone breakdown and capsular synovial metaplasia in textured-wall saline breast prostheses. Plastic and reconstructive surgery. 1994 Oct 1;94(5):628-33
Research & Reviews: A Journal of Health Professions
| Volume | 14 |
| Issue | 02 |
| Received | May 27, 2024 |
| Accepted | July 14, 2024 |
| Published | August 14, 2024 |