Hong Yong Chol,
Un Sim,
Choe Won Chol,
Jon Hye Son,
Ko Il Gyong,
- Researcher Department of Obstetrics and Gynecology, Pyongyang University of Medical Sciences Pyongyang Democratic People’s Republic of Korea
Abstract
We studied the morphologic changes in some organs and changes of learning and memory of the rat offspring after the embryonic bisphenol A exposure. Background: Bisphenol A, widely used as polycarbonate plastics material to manufacture food packaging, toys, glasses, computers, kitchen utensils and medical instruments, is one of the most common endocrine-disrupting chemicals. It is demonstrated that bisphenol A may be mingled with foodstuff and beverage from package and receptacle. Therefore, to clarify the effect of embryonic bisphenol A exposure to the postnatal mental and physical growth is very important. Objects and materials: Female Wistar rats with 190~210g in body weight were given BPA 50mg/kg/d in corn oil by stomach conductor from day 6 to day 21 after vaginal plug confirmation. On postnatal day 0, 7, 14, 21 body weight of offspring were measured. On postnatal day 21, some major organ weight index (organ weight per 100g body weight) including brains, hippocampus, testis of male offspring were measured and the histopathological test on hippocampus tissue were undertaken. On postnatal week 16, the uterus weight per 100g body weight of female offspring in estrus were measured and histopathological test on the uterus were undertaken. On postnatal day 30, 35, the changes of learning and memory of offspring were observed using radial maze instrument with eight way(arm) in direction, complicate maze instrument and water maze instrument Results: The embryonic bisphenol A exposure decreased the organ weight per 100g body weight of brain, hippocampus and uterus, the thickness and the number of cells, the thickness of the cell layer of hippocampus, the thickness of the uterine endometrium and the thickness of the epithelial cell layer. And the embryonic bisphenol A exposure decreased the ability of learning and memory of rat offspring.
Keywords: Bisphenol A, development, learning and memory learning and memory, Wistar rats, histopathology, radial maze, water maze, brain development, toxicology
[This article belongs to Research & Reviews : A Journal of Medical Science and Technology(rrjomst)]
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Research & Reviews : A Journal of Medical Science and Technology
| Volume | 13 |
| Issue | 02 |
| Received | February 9, 2024 |
| Accepted | May 27, 2024 |
| Published | August 13, 2024 |
