Alka Tyagi,
Pravin Roman,
Renuka Doiphode,
Sanjivani Chaudhary,
- Associate Professor Shri Pandit Baburao Chaughule College of Pharmacy, Thane Maharashtra India
- Associate Professor Shri Pandit Baburao Chaughule College of Pharmacy, Thane Maharashtra India
- Associate Professor Shri Pandit Baburao Chaughule College of Pharmacy, Thane Maharashtra India
- Associate Professor Shri Pandit Baburao Chaughule College of Pharmacy, Thane Maharashtra India
Abstract
Background: Schiff bases, a class of organic compounds, have garnered significant attention due to their diverse applications in various fields such as pharmaceuticals, materials science, and coordination chemistry. This abstract provides a comprehensive overview of the synthesis of Schiff bases amino pyridine derivatives and aromatic ketones along with their anti-microbial activity. Method: The synthesis of Schiff bases primarily involves the condensation reaction between a primary amine and a carbonyl compound (ketone) along with glacial acetic acid. Various methods have been developed for the synthesis of Schiff bases; Classical methods typically involve refluxing the amine and carbonyl compound in a suitable solvent with or without a catalyst. In these research nine new compounds of Schiff bases have been synthesized along with characterization and antibacterial and anti-fungal activities. Result: It was discovered that all elemental analysis, IR, 1H NMR, and mass spectrometry values were significant. According to antimicrobial and antifungal screening results, compounds PS-1 and compound PS-9 were found to be more active against all tested strains, while Schiff bases demonstrate substantial activity against Staphylococcus aureus and Candida albicans. PS-1 compound was found to have most activity in anti-bacterial test while PS-9 was found to possess best anti-fungal activity. Conclusion: The current study examines the pharmacological properties of pyridine derivatives. Pyridine derivative PS-1 was found to be most active antibacterial agent and PS-9 most active antifungal agent. The results of the study have important implications for future investigations into possible therapies for bacterial infections.
Keywords: Schiff base, Synthesis, Pharmacological evaluation, NMR spectroscopy, Pyridine derivatives.
[This article belongs to Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)]
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Research & Reviews: A Journal of Drug Design & Discovery
| Volume | 11 |
| Issue | 02 |
| Received | July 4, 2024 |
| Accepted | July 26, 2024 |
| Published | August 12, 2024 |