Marwa Azeez Akoul,
Dina Jamal Awad,
Sarah Salam Talib1,
Ruqayya Hadi Yunis,
Shimaa Dalil Mohammed,
Sondos Abdul Rahman Khalaf,
Duha Hazime Hadi,
Bahaa Aldeen Khaled Jwad,
Aisha Omar Majeed,
- Research Scholar, Department of Biotechnology, College of Applied Science, Al-Fallujah University, Iraq
- Department of Biotechnology, College of Applied Science, Al-Fallujah University, Iraq
Abstract
The aim of this study is to assess the level of SOD enzyme and its impact in people who are exposed to smoking, in addition to measuring C-interactive protein, and finally measure a complete picture of blood samples taken from patients. The results of the current study showed there is a significant differences (p<0.05) in the activity of the SOD. The mean of SOD activity in patient was 127.9 U/ml while the mean of the enzyme in the control was 96.00 U/ ml. CBC and CRP analysis for all (case and control ( were investigated, the existence of a relationship between each of them with the level of SOD enzyme due to its relationship with free radicals and due people exposed to smoking their body's efforts to adapt to the constant challenges they face. The results of the current study showed there is a significant differences (p<0.05) of CRP, the mean of CRP in patient was9.853 mg / dl while the mean of the CRP in the control was 4.917 mg / dl. Our results revealed significant differences (p<0.05) in WBC and P.C.V. The mean of WBC in patient was7.41 x103/μL while the mean of the WBC in the control was 6.98 x103/μL significant high due to the body's immune response to protect the body from the harmful effects
Keywords: SOD. CRP. Smoke. WBC. CBC
[This article belongs to International Journal of Toxins and Toxics(ijtt)]
References
- Saibi, W., & Brini, F. (2018). Superoxide dismutase (SOD) and abiotic stress tolerance in plants: An overview. Superoxide Dismutase: Structure, Synthesis and Applications; Magliozzi, S., Ed, 101-142.
- Fridovich, I. (1972). Superoxide radical and superoxide dismutase. Accounts of Chemical Research, 5(10), 321-326.
- Ighodaro, O. M., & Akinloye, O. A. (2018). First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria journal of medicine, 54(4), 287-293.
- Giustarini, D., Dalle-Donne, I., Tsikas, D., & Rossi, R. (2009). Oxidative stress and human diseases: origin, link, measurement, mechanisms, and biomarkers. Critical reviews in clinical laboratory sciences, 46(5-6), 241-281.
- Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. The international journal of biochemistry & cell biology, 39(1), 44-84..
- Bagchi, K., & Puri, S. (1998). Free radicals and antioxidants in health and disease: A review. EMHJ-Eastern Mediterranean Health Journal, 4 (2), 350-360, 1998..
- Beyer, Jr WF. Fridovich, I. Assaying for superoxide dismutase activity : some larg consequences of minor changes in conditions. Analytical biochemistry. (1998). Mar 1;161(2):559-66
- Ighodaro, O. M., & Akinloye, O. A. (2018). First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria journal of medicine, 54(4), 287-293.
- Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy reviews, 4(8), 118.
- Asthana, A., Johnson, H. M., Piper, M. E., Fiore, M. C., Baker, T. B., & Stein, J. H. (2010). Effects of smoking intensity and cessation on inflammatory markers in a large cohort of active smokers. American heart journal, 160(3), 458-463
- Pedersen, K. M., Çolak, Y., Ellervik, C., Hasselbalch, H. C., Bojesen, S. E., & Nordestgaard, B. G. (2019). Smoking and increased white and red blood cells: a mendelian randomization approach in the copenhagen general population study. Arteriosclerosis, thrombosis, and vascular biology, 39(5), 965-977.
- Ramesh, K. S. V., Swetha, P., Kumar, P. M., Sruthima, N. V. S., & Kumar, C. N. (2019). Estimation of superoxide dismutase levels in saliva and gingival crevicular fluid among smokers and non-smokers in periodontitis patients-An Observational Study. Nigerian Medical Journal, 60(3), 133-137.
- Alkhedaide, A. Q. (2020). Tobacco smoking causes secondary polycythemia and a mild leukocytosis among heavy smokers in Taif City in Saudi Arabia. Saudi journal of biological sciences, 27(1), 407-411.
International Journal of Toxins and Toxics
| Volume | 01 |
| Issue | 02 |
| Received | April 6, 2024 |
| Accepted | January 7, 2024 |
| Published | August 12, 2024 |