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Sd. Riaz Hussain Chistia, N. Jyothi Reddy, H. Padma Latha, CH. Sri Divya, S. Deepa,
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Abstract
nThe present study was aimed to formulate and evaluate Metoclopramide hydrochloride medicated lozenges to provide the antiemetic action through the buccal absorption by the addition of polymer. All formulations were prepared and evaluated for in-vitro drug release, physical appearance, weight variation, thickness, hardness, moisture content, mouth dissolving time and drug content. The formulated lozenges showed the uniformity in weight and thickness. The hardness of all formulated lozenges was found within the standard range up to 7.3 kg/cm2 to 15.50 kg/cm2. Mouth dissolving time of medicated lozenges was found to be within the range upto 7:06 to 30:28 minutes. F10 formulation showed the maximum time to dissolve in a medium. The standard limits of moisture content should be in the range of 0.5 to 1.5%. As per the result obtained that moisture content in the prepared lozenges was found in the range 0.5 to 1.5% which is within the standard limits. The drug content of all formulated lozenges (F1 to F10) was within the acceptable limits (90%-110%). From the in-vitro drug release study, it was found that the formulations, Metoclopramide hydrochloride lozenges containing Methyl cellulose in the concentrations of 0.75%, 0.5%, 0.25% showed the maximum drug release at 30 minutes. Among those formulations formulation F10 showed 100.6% of drug release. The in-vitro release kinetic study of the optimized formulation (F10) was found to be first order. The release of the dosage form follows the diffusion and dissolution mechanism and Non-Fickian diffusion mechanism. From the present work, it can be concluded that Isomalt can be successfully used as the tooth friendly sugar substitute in the formulation of medicated lozenges and owing to its low caloric value and its ability to withstand formation of plaques, it could be used safely for diabetic and paediatric patient concerns.
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Keywords: Formulation Development, Evaluation, Metoclopramide Hydrochloride, Hard Candy Lozenges
n[if 424 equals=”Regular Issue”][This article belongs to International Journal of Biomedical Innovations and Engineering(ijbie)]
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References
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1. Meghwal M, Goswami TK. Chemical Composition, Nutritional, Medicinal and Functional Properties of Black Pepper: A Review. Open Acc Sci Rep. 2012; 1:1-5. 2. Paul M, ESCMID Guideline for the Management of Acute Sore Throat, 2012; 18: ESCMID, 1-18. 3. Maheshwari Rachana, Jain Vikas, Ansari Rehana et al. A Review on lozenges. Journal Home Page www.bbbulletin.org. 2013; 1(1): 35-43. 4. Munot M., Sharma Neha, Gujar N. Kishore. Orodental Delivery Systems. International Journal of Pharm. and Pharmaceutical Science. 2013; 5(3):1-10. 5. Maheshwari R, Jain V, Ansari R, Mahajan SC, Joshi G. A review on lozenges. BBB, 2013; 1-9. 6. Shinde SG, Kadam V, Kapse GR, Jadhav SB, Zameeruddin, Bharkad VB. A review on lozenges. IAJPR, 2014; 4(2): 567-570 7. Pothu R and Yamsani MR. Lozenges formulation and evaluation: A review. IJAPR. 2014; 1: 290-294. 8. Shinde Satish G, Kadam Vaishali, Kapse G.R.et al. A Review on lozenges. Indo American Journal of Pharmaceutical Research. 2014; 4(1): 566-571. 9. Pundir Suchitra, Verma Abhay, Murari Lal. A Review on lozenges. Journal der Pharma. Forschung. 2014; 2(1): 1-10.
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International Journal of Biomedical Innovations and Engineering
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| Volume | 02 | |
| [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] | 02 | |
| Received | March 26, 2024 | |
| Accepted | April 9, 2024 | |
| Published | April 29, 2024 |
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