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Padma Latha, N.Jyothi Reddy, J.Manjula, CH.Sri vidya, Sd.Riaz Hussain chistia
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Abstract
nSilver nanoparticles were synthesized using Pterocarpus marsupium bark extract in combination with silver nitrate solution through a green synthesis method. Silver nanoparticles formation was confirmed by the formation of dark brown from solution of silver nitrate, where the reduction of silver ion occurs which leads to the formation of silver nanoparticles. The UV–visible spectra showed a peak at 429 nm, confirming the reduction of silver ions and the subsequent synthesis of silver nanoparticles. FTIR analysis of Pterocarpus marsupium Roxb. identified hydroxyl, carboxyl, and phenolic groups responsible for effectively capping and stabilizing the Ag nanoparticles through their reducing and capping properties. Additionally, drug entrapment efficacy testing demonstrated a high percentage of 95% for drug entrapment efficiency.
SEM analysis was conducted to examine the structural and morphological characteristics of the synthesized Pterocarpus marsupium silver nanoparticles, revealing the presence of polydisperse spherical shapes. Particle size distribution was evaluated using a zeta sizer, indicating an average particle size of 36.44 nm with a polydispersity index of 0.825 and an intercept of 0.781. Zeta potential measurement was found to be -22.6 mV with the peak areas of 100% intensity and these values indicate formulated nanoparticles are stable. In vitro drug release data were examined at various time intervals, and the release kinetics were assessed using zero-order, Higuchi, and Korsmeyer-Peppas models. The analysis indicated that the Higuchi model provided the best fit for the release data, with an R2 value of 0.9877. The Korsmeyer-Peppas equation demonstrated strong linearity, characterized by a release exponent “n” of 0.167, which verified that the formulation followed Fickian diffusion kinetics.
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Keywords: Preparation, Characterization, Green Synthesized Silver Nanoparticles, Pterocarpus marsupium
n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Bioinformatics(rrjobi)]
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| Volume | 11 | |
| [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] | 02 | |
| Received | March 15, 2024 | |
| Accepted | March 20, 2024 | |
| Published | April 15, 2024 |
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