Vaishnavi. P kandhare
Sandip A. Tadavi
Sunil P. Pawar
- Student M Pharm Department of Pharmaceutical Quality Assurance, P.S.G.V.P.M’S College of Pharmacy and Research Maharashtra India
- Assistant Professor Department of Pharmaceutical Quality Assurance, P.S.G.V.P.M’S College of Pharmacy and Research Maharashtra India
- Principal P.S.G.V.P.M’S College of Pharmacy and Rsearch Maharashtra India
Abstract
When taken orally, medications with a limited window of absorption in the gastrointestinal tract (GIT) are typically accessible to the extremities due to the partial release of the active component and the brief residence period at the absorption site. Because they prolong the duration of the drug’s presence in the stomach, they are made for high density and have the capacity to swell. Because oral fluids go more quickly through the stomach and duodenum, they are more likely to have limited bioavailability. This method works effectively for both the local and systemic effects of medications. Making them into oral gels is the most effective way to deal with the overdose problem. Gel formulation is dependent on various parameters, including ph variations, presence of ions, temperature modulation, and ultraviolet irradiation, which releases the medication in a regulated and sustained manner.The aim of this investigation was to create an innovative in-situ gel. The polymers used in the system display a sol-to-gel phase transition as a result of alterations in particular physico- chemical properties. The in-situ gel will remove the contents of the gastrointestinal tract and was created at a biological pH. The viscosity, drug concentration, pH, in vitro gelling capacity, in vitro floating ability, and controlled and sustained drug release were all as expected for the in-situ gel. Greater maintenance and long-lasting alleviation are attained in this way. Guar gum, Xanthan gum, sodium alginate, gellan gum, pectin, chitosan, sodium benzoate, sodium citrate, polyethylene glycon, and hydroxy propyl methyl cellulose are a few of the polymers utilized in in-situ gelling systems. An overview of the preliminary in-situ oral floating gel experiments on various medications and polymers, carried out by various scientists, is given in this article.
Keywords: Floating Drug Delivery, Gastric Retention Time, In-Situ Gel, Innovative drug delivery techniques, Mucoadhesive.
[This article belongs to Research & Reviews: A Journal of Drug Formulation, Development and Production(rrjodfdp)]
References
1) Gayen Sudipa ,A review on floating oral in situ gelling system, International Research Journal of Modernization in Engineering Technology and Science,2021,vol-03(6),Pg: 1816-1823
2) Jocob Susan , Oral In-Situ Gelling System: A Review,JPSR.2020,vol-12(8),PN-1056-1061
3) Sudhi US, Kumar SS, Nowfiya FN, Mathan S, Dharan SS. Floating oral in-situ gelling system: A review. Journal of Pharmaceutical Sciences and Research. 2020 Oct 1;12(10):1315-9.
4) Bashir R, Majeed A, Ali T, Farooq S, Khan NA. Floating oral in-situ gel: a review. Journal of Drug Delivery and Therapeutics. 2019 Mar 15;9(2):442-8.
5) Rahul Dheple, Anup Akarte, Pankaj Chaudhari, Pankaj Patil, Prakash Patil. (2021). A Review onGastro-retentive Floating In-situ Gel. Int. J. Adv. Multidiscip. Res. 8(7): 9-19.
6) Salunkhe Nilesh P. et.al., Oral in-situ floating gelling system: Review on. World. J. Pharm. and Pharma. Sci. 2019,8[4],478-496.
7) Firoz Sarada K, S, Padmin K., In-situ gelling system: A review. Int.J.Curr.Pharm.Rev.Res.2015,5[4],76-90.
8) Gopalakrishnan S., Centilnathan A. Floating drug delivery system: a review. J. Pharm. Sci. Science and Technology, 2011; 548-554.
9) Padhan Ashutosh, B.K. Nanda and B. C. Behera., Floating oral insitu gel, A comprehensive approach of gastro-retentive drug delivery system: A review. Int.J.Pharma.Sci.2019,10[9],4026-4039.
10) Sivannarayana T, et.al., Formulation and evaluation of oral floating in situ gel of moxifloxacin HCl. Indo.Am.J.pharm.res.2013,3[10],8211-8221.
11) Rabiah Bashir et.al., Floating oral in-situ gel: A review.J.drug delivery.ther.2019,6[2]442-448.
12) B.Nirmal H., Bakliwal S.R, Pawar S.P., In-situ gel: New trends in controlled and sustained drug delivery system. Int.J.pharmtech Res..2010,2[2],1398-1408.
13) Raut S.S and .Shinde H.A., In-situ raft forming system : A review. nt.J.pharmacogn..2018,5[6],337-349.
14) Chandel A., Chauhan K., Parashar B., Hiteshkumar, Arora S. Floating drug delivery system: a better way. International. News Medical Journal, 2012; 110-11
15) Jain N. K. and S. Gopalakrishnan K. Progress in the drug control system. Journal of Pharmaceutical Technology, 2011; 3:548-554.
16) Lamia DD. In-situ gel system: a potential drug therapy tool. International. J Pharmacy Phar 5 (3): 27-30
17) Burkot A. K., Anset K. S. Overview of phosphoric anhydride: the formation of in-situ degradable networks. 2000; 21: 2395-404.
18) Tandel H, Bhatt P., Jain K., Shahiwala A., Misra A. In vivo instruments in new drug delivery scenarios: Channel update B: Misra ASA, editor, in vitro and in vivo drug delivery studies for best clinical results, Boc Press ; 2018.
19) Patel JK, Chavda JR, Modasia MK alginate-based in-situ floating gels are used as carriers for gastricspecific famotidine drug delivery. International Journal of Pharmacy, 2010; 3 (3): 1092-1104
20) Geraghty PB, Attwood D, Collett JH, Sharma H, Dandiker Y. An investigation of the parameters influencing the bioadhesive properties of Myverol 18-99/water gels. Biomaterials. 1997 Jan;18(1):63-7. doi: 10.1016/s0142-9612(96)00087-7.
21) R.Ramesh C, Zentner GM and Jeong B.Ma are biodegradable low molecular weight polyethylene glycol triblock copolymers with revolutionary gel properties. US Patent2001, 6201072.intestinal preparations Pharma.Tech, 2003; 27:50-68.
22) Talukder R, Fassihi R. Gastroretentive delivery systems: a mini review. Drug Dev Ind Pharm. 2004;30(10):1019-28. doi: 10.1081/ddc-200040239
23) Jain N. K. and Gopalakrishnan K.S. Progress in the drug control system. Journal of Pharmaceutical Technology, 2011; 3:548-554.
24) Burkot A. K., Anset K. S. Overview of phosphoric anhydride: the formation of in-situ degradable networks. 2000; 21: 2395-404.
25) P. Nilesh,Salunkhe,Patil Dipak A.,A. Sandip ,Tadavi, Pawar Sunil P., Oral in situ floating delling system. ISO 9001 ,2015
26) Wagh VD, Deshmukh KH, Wagh KV. Preparation and evaluation of an in-situ gel drug delivery system of Sesbania flower extract for the treatment of bacterial conjunctivitis. J. Pharm. Res. 2012; 4: 1880-1884.
27) N.Rahul, Venkatakrishnakiran P., Dhanalakshmi P., Prasannaraju Y. Compilation and evaluation of an in-situ gel system for the introduction of doxycycline hydrochloride into the eye. Journal of Pharmaceutical Science Innovation Trends.2012; vol-3:PN;1-7.
28) Wataru K, Yasuhiro K, Miyazaki S, Attwood D, In situ pectin gel forming preparation for long-term oral paracetamol, Drug Develop Ind Pharm, 2004, 30, 593-9.
29) Calfres J, Edsman K, Peterson R, Rheological evaluation of poloxamer as an in-situ gel for surgery, Eur J Pharm Sci;2006.VOL-6, PN-105.
30) Pant.s, badola.a, kothiyal.p, A Review on gastro-retentive drug delivery system, IJRDLl,july 2016:5:4:2178-2187.
31) Patel V, Patel A, Patel H.ed.al, A Review on in-situ gelling system: Novel approach for stomach, IJPRBS, 2014:3(2):466-480
32) Rabiash Bashir, Asmat Majeed, Tabasum Ali, Saeema Farooq, Nisar Ahmad Khan. Floating Oral In-situ Gel: A Review. JDDT, 2019; 9(2): 442-448.
33) Harish NM, Prabhu P, Charyulu RN, Gulzar MA, Subrahmanyam EV. Formulation and Evaluation of in situ Gels Containing Clotrimazole for Oral Candidiasis. Indian J Pharm Sci. 2009 Jul;71(4):421-7. doi: 10.4103/0250-474X.57291.
34) Joshi A, Ding S, Himmeistein KJ, Reversible gel composition and method of use, 12. October 1993, US Patent No. 5,252-318.
35) Kavitha K, Rajas, New Jersey. Sustained ophthalmic delivery of levofloxacin hemihydrate from an ionactivated in-situ gel system. International. J. Medical technology. Resolution in 2011; 3:2:702-706.
36) Patel JK, Chavda JR, Modasiya MK. Floating In situ Gel Based on Alginate As Carrier for Stomach-Specific Drug Delivery of Famotidine. IJPSN. 2010; Vol:3:(3) 1092-1104.
37) Bhovmik D, Bhanot R, Gautam R, Rai P and Sampat Kumar KP: Delayed GI drug delivery system: a new way to control the drug delivery system. Science and Technology Research Journal 2018; 10:1-12
38) Porval A., Dwivedi H. and Patak K. Decades of research on the choice of antihypertensive therapy using gastric retention drug delivery systems. Brazilian Journal of Pharmaceutical Sciences 2017; 53:(3)1-15
39) Bhowmik D, Bhanot R, Gautam R, Rai P and Sampath Kumar KP: Gastro-retentive Drug Delivery Systems- A Novel Approaches of Control Drug Delivery Systems. Research Journal of Science and Technology 2018; 10:2: 1-12.
40) Parmar PD, Pande S, Shah SH, Sonara N. Floating Drug Delivery System: A Novel Approach To Prolong Gastric-retention. World J Pharmacy Pharm Sci, 2014; 3(4):418-444.
41) Gopalakrishnan S., Centilnathan A. Floating drug delivery system: a review. J. Pharm. Sci. Science and Technology, 2011; Vol 3(2),548-554.
| Volume | 11 |
| Issue | 02 |
| Received | April 19, 2024 |
| Accepted | July 6, 2024 |
| Published | July 17, 2024 |
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