Exploring the Boundless Applications of Chitosan: From Biomedical Marvel to Environmental Saviour

Year : 2024 | Volume :10 | Issue : 01 | Page : 01-09
By

Sandeep Rai

  1. General Manager R&D, Dyne Chemicals LLP, Chatral GIDC, Phase IV, Taluka- Kalol, Gandhinagar, Gujrat India

Abstract

Chitosan has attracted much interest because of its versatile properties and possible numerous usages in diversified industrial applications. Chitosan is having poor solubility in neutral and basic media and this is limiting its use. Chitosan is not a single polymer and do not have a defined structure. Chitosan is family of molecules with different composition, size & monomer units’ distribution and these characteristics have effect on the biological & technological performance of Chitosan. Dedicated research work is underway to sort out the problems of its poor solubility and improving polymer properties. Chitosan is a derivative of chitin is emerged as a versatile biomaterial with numerous applications across various industries. This article delves into the properties, production methods, and diverse applications of chitosan, ranging from biomedical to environmental fields. From wound healing to water treatment, chitosan’s versatility and biodegradability makes it a promising candidate for medical, agriculture and food applications. This review article aims to throw light on the vast potential of chitosan and its role in shaping the future of multiple industries.

Keywords: Chitosan, Chitin, Biological Activity, Drug Delivery, Antioxidant, Antimicrobial, Aetallic Nanoparticles, Bio-catalysis.

[This article belongs to International Journal of Analytical and Applied Chemistry(ijaac)]

How to cite this article: Sandeep Rai. Exploring the Boundless Applications of Chitosan: From Biomedical Marvel to Environmental Saviour. International Journal of Analytical and Applied Chemistry. 2024; 10(01):01-09.
How to cite this URL: Sandeep Rai. Exploring the Boundless Applications of Chitosan: From Biomedical Marvel to Environmental Saviour. International Journal of Analytical and Applied Chemistry. 2024; 10(01):01-09. Available from: https://journals.stmjournals.com/ijaac/article=2024/view=0

References

  1. Kassem A., Ayoub G.M., Malaeb L. Antibacterial Activity of Chitosan Nano-Composites and Carbon Nanotubes: A Review. Total Environ. 2019; 668:566–576. doi: 10.1016/j.scitotenv.2019.02.446. [PubMed] [CrossRef] [Google Scholar]
  2. Pervez M.N., Balakrishnan M., Hasan S.W., Choo K.H., Zhao Y., Cai Y., Zarra T., Belgiorno V., Naddeo V. A Critical Review on Nanomaterials Membrane Bioreactor (NMS-MBR) for Wastewater Treatment. npj Clean Water. 2020;3:43. doi: 10.1038/s41545-020-00090-2. [CrossRef] [Google Scholar]
  3. Yadav M., Goswami P., Paritosh K., Kumar M., Pareek N., Vivekanand V. Seafood Waste: A Source for Preparation of Commercially Employable Chitin/Chitosan Materials. Bioprocess. 2019;6:8. doi: 10.1186/s40643-019-0243-y. [CrossRef] [Google Scholar]
  4. Upadhyay U., Sreedhar I., Singh S.A., Patel C.M., Anitha K.L. Recent Advances in Heavy Metal Removal by Chitosan Based Adsorbents. Polym. 2021; 251:117000. doi: 10.1016/j.carbpol.2020.117000. [PubMed] [CrossRef] [Google Scholar]
  5. Kulkarni N., Shinde S.D., Jadhav G.S., Adsare D.R., Rao K., Kachhia M., Maingle M., Patil S.P., Arya N., Sahu B. Peptide-Chitosan Engineered Scaffolds for Biomedical Applications. Bioconjugate Chem. 2021;32:448–465. doi: 10.1021/acs.bioconjchem.1c00014. [PubMed] [CrossRef] [Google Scholar]
  6. Negi H., Verma P., Singh R.K. A Comprehensive Review on the Applications of Functionalized Chitosan in Petroleum Industry. Polym. 2021;266:118125. doi: 10.1016/j.carbpol.2021.118125. [PubMed] [CrossRef] [Google Scholar]
  7. Salama A. Recent Progress in Preparation and Applications of Chitosan/Calcium Phosphate Composite Materials. J. Biol. Macromol. 2021;178:240–252. doi: 10.1016/j.ijbiomac.2021.02.143. [PubMed] [CrossRef] [Google Scholar]
  8. Jaber N., Al-Remawi M., Al-Akayleh F., Al-Muhtaseb N., Al-Adham I.S.I., Collier P.J. A Review of the Antiviral Activity of Chitosan, Including Patented Applications and Its Potential Use against COVID-19. Appl. Microbiol. 2022;132:41–58. doi: 10.1111/jam.15202. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  9. Sharifianjazi F., Khaksar S., Esmaeilkhanian A., Bazli L., Eskandarinezhad S., Salahshour P., Sadeghi F., Rostamnia S., Vahdat S.M. Advancements in Fabrication and Application of Chitosan Composites in Implants and Dentistry: A Review. 2022;12:155. doi: 10.3390/biom12020155. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  10. Spoială A., Ilie C.I., Ficai D., Ficai A., Andronescu E. Chitosan-Based Nanocomposite Polymeric Membranes for Water Purification—A Review. 2021;14:2091. doi: 10.3390/ma14092091. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  11. Bhardwaj, N. and S.C. Kundu, Electrospinning: a fascinating fibre fabrication technique. Biotechnology advances, 2010. 28(3): p. 325-347.
  12. Lee, K.Y., et al., Electrospinning of polysaccharides for regenerative medicine. Advanced Drug Delivery Reviews, 2009. 61(12): p. 1020-1032.
  13. Hudson, S.M. and D.W. Jenkins, Chitin and chitosan, Encyclopedia of polymer science and technology, 2001, NJ: Wiley Interscience
  14. Aranaz, I.; Alcántara, A.R.; Civera, M.C.; Arias, C.; Elorza, B.; Heras Caballero, A.; Acosta, N. Chitosan: An Overview of Its Properties and Applications. Polymers 2021, 13, 3256. https://doi.org/ 10.3390/polym13193256.
  15. No, H.K. and S.P. Meyers, Preparation and characterization of chitin and chitosan—a review. Journal of aquatic food product technology, 1995. 4(2): p. 27-52.
  16. Aranaz, I.; Mengíbar, M.; Harris, R.; Paños, I.; Miralles, B.; Acosta, N.; Galed, G.; Heras, A. Functional characterization of chitin and chitosan. Curr. Chem. Biol. 2009, 3, 203–230. Aranaz; Mengíbar, M.; Harris, R.; Paños, I.; Miralles, B.; Acosta, N.; Galed, G.; Heras, A. Functional characterization of chitin and chitosan. Curr. Chem. Biol. 2009, 3, 203–230.
  17. Ways, T.M.M.; Lau, W.M.; Khutoryanskiy, V.V. Chitosan and its derivatives for application in mucoadhesive drug delivery systems. Polymers 2018, 10, 267. [CrossRef] [PubMed]
  18. Sizílio, R.H.; Galvão, J.G.; Trindade, G.G.G.; Pina, L.T.S.; Andrade, L.N.; Gonsalves, J.K.M.C.; Lira, A.A.M.; Chaud, M.V.; Alves, T.F.R.; Arguelho, M.L.P.M.; et al. Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis. Carbohydr. Polym. 2018, 190, 339–345. [CrossRef] [PubMed]
  19. Azuma, K.; Osaki, T.; Minami, S.; Okamoto, Y. Anticancer and Anti-Inflammatory Properties of Chitin and Chitosan Oligosaccha rides. J. Funct. Biomater. 2015, 6, 33–49. [CrossRef] [PubMed]
  20. Avelelas, F.; Horta, A.; Pinto, L.F.V.; Marques, S.C.; Nunes, P.M.; Pedrosa, R.; Leandro, S.M. Antifungal and antioxidant properties of chitosan polymers obtained from nontraditional Polybius henslowii sources. Mar. Drugs 2019, 17, 239. [CrossRef]
  21. Ke, C.L.; Deng, F.S.; Chuang, C.Y.; Lin, C.H. Antimicrobial actions and applications of Chitosan. Polymers 2021, 13, 904. [CrossRef]
  22. Shih, P.Y.; Liao, Y.T.; Tseng, Y.K.; Deng, F.S.; Lin, C.H. A potential antifungal effect of chitosan against candida albicansis mediated via the inhibition of SAGA complex component expression and the subsequent alteration of cell surface integrity. Front. Microbiol. 2019, 10, 602. [CrossRef]
  23. Sarkar, S.; Das, D.; Dutta, P.; Kalita, J.; Wann, S.B.; Manna, P. Chitosan: A promising therapeutic agent and effective drug delivery system in managing diabetes mellitus. Carbohydr. Polym. 2020, 247, 116594. [CrossRef]
  24. Amirani, E.; Hallajzadeh, J.; Asemi, Z.; Mansournia, M.A.; Yousefi, B. Effects of chitosan and oligochitosans on the phosphatidyli nositol 3-kinase-AKT pathway in cancer therapy. Int. J. Biol. Macromol. 2020, 164, 456–467. [CrossRef] [PubMed]
  25. Ueno,H.; Mori, T.; Fujinaga, T. Topical formulations and wound healing applications of chitosan. Adv. Drug Deliv. Rev. 2001, 52, 105–115. [CrossRef]
  26. https://www.precedenceresearch.com/chitosan-market
Regular Issue Subscription Review Article
Volume 10
Issue 01
Received June 14, 2024
Accepted June 20, 2024
Published July 10, 2024
Views: 9

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