In Situ Investigation of Hemidesmus Indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukaemia

Year : 2024 | Volume :13 | Issue : 01 | Page : 32-47
By

Roshithaa Pillai

  1. Research Intern Department of Bioinformatics, BioNome Karnataka India

Abstract

Objective: Acute myeloid leukaemia is an apoptotic condition in the hematopoietic system induced by differentiation and immaturation of stem cells into erythrocytes, Leukemic cell proliferation is suppressed as PI3K Akt mTOR pathway is pharmacologically targeted with certain inhibitors. As a result, in silico molecular docking of compounds against AML receptors CTMP is used in computational research from H.indicus to uncover therapeutic phytochemicals for AML. Thus, the study s conclusion is that, identification of natural product based therapeutic candidates can be facilitated by the combination of empirical information, in silico molecular docking, and ADME profiling.
Methods: An in-silico examination for the treatment of AML. In this study, the phytoconstituents of Hemidesmus indicus, have been thoroughly reviewed on the basis of its cylindrical root as a natural remedy for the ailment. The pharmacology of selected compounds underwent screening with respect to ADME drug-likeness properties. Ultimately, the screening process was finalized by employing PyRx and Biovia to dock the chosen compound with the leukemic-targeted suppressor protein.
Results: Current in silico study on AML, Quercetin, the most abundant flavonoids with multiple properties capable of reducing cell growth in cancer cells with acute myeloid leukemic condition.
Conclusion: Overall, the notable insights in pharmacological research studies on AML at the level of its immature stem cells, better understanding of the molecular mechanism of the disorder, would be beneficial to recommend H.indicus root as therapeutic targets. AML related protein is retrieved from PDB database for molecular docking results in the discovery of new drug and medicinal therapeutic aqueous of most effective root-based H.Indicus was extracted. CTMP protein acts as an anti-leukemic suppressor protein which develops effective protein-ligand complexes.

Keywords: Hemidesmus Indicus, Acute myeloid leukaemia, phytocompounds, pharmacology, apoptosis, therapeutic targets.

[This article belongs to Research & Reviews : Journal of Computational Biology(rrjocb)]

How to cite this article: Roshithaa Pillai. In Situ Investigation of Hemidesmus Indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukaemia. Research & Reviews : Journal of Computational Biology. 2024; 13(01):32-47.
How to cite this URL: Roshithaa Pillai. In Situ Investigation of Hemidesmus Indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukaemia. Research & Reviews : Journal of Computational Biology. 2024; 13(01):32-47. Available from: https://journals.stmjournals.com/rrjocb/article=2024/view=151230

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Regular Issue Subscription Original Research
Volume 13
Issue 01
Received March 27, 2024
Accepted April 3, 2024
Published April 13, 2024
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