Pharmacological Management of Parkinson’s Disease: Current Therapies and Emerging Treatments

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    Sheilina Choudhary

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    1. Student,Department of Biotechnology, Shoolini University of Biotechnology and Management Sciences,,Himachal Pradesh,India

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    Abstract

    nObjective: Parkinson’s disease, behind Alzheimer’s, is the second most common neurodegenerative ailment and a major cause of neurological morbidity worldwide. Clinical diagnosis is made, and current management is limited to symptomatic treatments, with levodopa remaining the cornerstone of pharmaceutical therapy. In certain patient groups, deep brain stimulation of specific basal ganglia targets can provide significant clinical relief. There are currently no proven disease-modifying medicines in clinical use that can halt or reverse the underlying neurodegenerative process. Methods: In this investigation, target proteins were downloaded from the PDB and docked in Biovia. The ligands’ and standard medications’ binding affinity with each target protein was compared and assessed. Also, only 4 substances were choosen for SWISS-ADME final results. Results: The docking result revealed that the ligands selected have the best binding affinity with all the three target proteins. Conclusion: The ligands could potentially be used to treat Parkinson’s Disease in the future approaches for studying the urge ligands in vitro and in vivo analysis in order to create novel parkinson’s inhibitors.

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    Keywords: Parkinson’s Disease, Phytocompounds, Molecular docking, SWISS-ADMET analysis, Levodopa

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    Full Text

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    References

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    Regular Issue Subscription Original Research

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    Volume 01
    Issue 01
    Received April 13, 2023
    Accepted May 4, 2023
    Published May 18, 2023

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    Editor

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