Research & Reviews: A Journal of Pharmaceutical Science

Research and Reviews: A Journal of Pharmaceutical Science

Research and Reviews: A Journal of Pharmaceutical Science [2229-7006(e)] is a peer-reviewed hybrid journal launched in 2010 and focused on the rapid publication of fundamental research papers in all areas of Pharmaceutical Sciences. The Journal intends to publish all recent advancements in the field of Pharmaceutics.

The journal welcomes contributions across the following topic areas:

• Formulation Engineering & Processing: formulation design and drug product development, particle engineering and multiphase processes, bioengineering approaches to formulation, food and nutrition interactions with pharmaceuticals, microstructure and material properties, sustainability and reprocessing in pharmaceutical manufacturing, computational biopharmaceutics and modeling, and outcomes and efficacy of formulation strategies.
• Molecular Biopharmaceutics & Drug Disposition: drug absorption and bioavailability assessment, biopharmaceutical classification system and BDDCS, drug disposition and pharmacokinetic parameters, food effects on drug absorption and metabolism, transporter interactions and active transport, in silico modeling and molecular docking, homology modeling and protein structure prediction, and disposition outcomes and clinical pharmacokinetics.
• Pharmacokinetics, Pharmacodynamics & Pharmacogenetics: pharmacokinetic parameter estimation and dosing algorithms, pharmacodynamic modeling and drug effects, dose-response relationships and optimization, genetic polymorphisms and drug response variation, pharmacogenomic testing and personalized dosing, immunosuppressant monitoring in transplantation, therapeutic drug monitoring and dose adjustments, and outcomes in personalized and precision medicine.
• Drug Metabolism & Biotransformation: phase I, II, and III metabolic pathways, cytochrome P450 enzyme kinetics and inhibition, conjugation and metabolite formation, bioactivation and reactive metabolite formation, drug-drug interactions and metabolism, liver metabolism and hepatic clearance, metabolite identification and characterization, and safety and toxicity implications of metabolism.
• Metabolic Disposition & Genetic Factors: single nucleotide polymorphisms and genetic variation, thiopurine S-methyltransferase and thymidylate synthase polymorphisms, dihydropyrimidine dehydrogenase deficiency and drug response, ATP-binding cassette transporters and drug resistance, multidrug resistance-associated proteins and efflux, cancer health disparities and pharmacogenomics, genetic biomarkers and personalized therapy, and outcomes in pharmacogenetic-guided treatment.
• Protein & Peptide Chemistry: free amino acid and peptide synthesis, soy protein and protein isolates, essential amino acids and nutritional assessment, peptide chain engineering and modification, native chemical ligation and bioconjugation, thioester chemistry and peptide coupling, protein-peptide interactions and binding, and development and applications of bioactive peptides.
• Pharmaceutical Toxicology & Safety: absorption enhancers and permeability modification, adeno-associated virus and viral vector toxicology, adenoviral vectors and immunogenicity, albumin and protein binding, alginate and polysaccharide toxicity, allometry and scaling in toxicity assessment, Alzheimer’s disease drug safety and biomarkers, amorphous solid dispersions and stability, and comprehensive safety evaluation of pharmaceuticals.
• Pharmaceutical Nanotechnology: nanoparticle design and characterization, liposomes and lipid-based nanoformulations, nanotube applications and drug delivery, drug delivery systems and targeted therapy, diagnostic and prognostic nanotechnology, nano-engineered tools and biomarkers, nasal and brain delivery of nanotherapeutics, lung cancer treatment with nanoparticles, and outcomes and clinical translation of nanomedicines.
• Pharmaceutical Validation & Quality Assurance: process validation and equipment qualification, analytical method validation and verification, computer system validation and cybersecurity, facility validation and HVAC systems, cleaning validation and residue limits, documentary evidence and regulatory compliance, continuous improvement and quality management, and quality assurance and regulatory standards.
• Quality Control & Manufacturing: quality management and statistical process control, manufacturing process development and scale-up, inspection and audit procedures, engineering and technical support, construction management and facility planning, batch testing and specification compliance, in-process monitoring and controls, and outcomes and compliance in pharmaceutical manufacturing.
• Pharmaceutical Analysis & Testing: analytical chemistry and separation techniques, absorption spectroscopy and chromatography, analytical biochemistry and quantitation methods, automation and high-throughput screening, mass spectrometry and structural identification, dissolution testing and bioavailability assessment, stability testing and shelf-life prediction, and analytical method development and validation.
• Drug Design, Discovery & Development: prodrug development and prodrug design, medicinal chemistry and structure-activity relationships, computer-aided drug design and molecular modeling, high-throughput screening and compound libraries, lead optimization and candidate selection, patent and intellectual property strategies, regulatory pathway and approval timelines, and outcomes in drug discovery and development.