Research & Reviews: A Journal of Pharmacology

Research and Reviews: A Journal of Pharmacology

Research & Reviews: A Journal of Pharmacology [2230-9861(e)] is a peer-reviewed hybrid open-access journal launched in 2011 and focused on the rapid publication of fundamental research papers on all areas of Pharmacology.

The journal welcomes contributions across the following topic areas:

• Clinical Pharmacology: clinical drug effects and therapeutic outcomes, plasma drug concentrations and therapeutic drug monitoring, dose-response relationships and partial agonism, biochemical receptors and transporter function, agonists and antagonists in clinical practice, signaling pathways and molecular mechanisms, enzyme inhibitors and activators, ion channel modulation, and optimization of clinical drug therapy.
• Neuropharmacology & CNS Drugs: mechanisms of neuroactive drugs and drug-receptor interactions, neurotransmitter systems and receptor pharmacology, blood-brain barrier pharmacokinetics and drug penetration, neurodegenerative disease treatment and neuroprotection, pain management and analgesic pharmacology, addiction pharmacology and substance use disorder treatment, psychiatric medication mechanism and efficacy, and neurological outcomes and patient safety.
• Psychopharmacology & Psychiatric Medications: antipsychotic drugs and atypical antipsychotics, mood stabilizers and bipolar disorder treatment, antidepressants and depression management, benzodiazepines and anxiolytics, psychostimulants and ADHD treatment, mental health medication efficacy and side effects, psychiatric medication combinations and interactions, and psychiatric outcomes and therapeutic response.
• Pharmacokinetics & Drug Metabolism: drug absorption and bioavailability, distribution and protein binding, metabolism and biotransformation pathways, cytochrome P450 enzyme kinetics and drug interactions, phase I, II, and III metabolism, conjugation and metabolite formation, liver metabolism and hepatic elimination, renal excretion and clearance, and pharmacokinetic parameter estimation and dosing optimization.
• Pharmacodynamics & Receptor Pharmacology: drug-receptor interactions and binding kinetics, G protein-coupled receptors and signaling, opioid receptors and pain modulation, phospholipase C and protein kinase C pathways, aromatase inhibitors and hormone receptor effects, structure-activity relationships and drug design, dose-response curves and efficacy assessment, and functional outcomes in pharmacodynamic studies.
• Adverse Drug Reactions & Pharmacovigilance: drug safety monitoring and surveillance, spontaneous adverse event reporting systems, black box warnings and safety alerts, drug recalls and withdrawal decisions, risk management plans and mitigation strategies, drug-induced agranulocytosis and hematologic toxicity, elderly patients and age-related pharmacovigilance, infection management in adverse reactions, and pharmacovigilance outcomes and public health impact.
• Molecular Pharmacology & Cell Biology: molecular diagnostics and pharmacogenomics, DNA extraction and analysis techniques, polymerase chain reaction and quantitative PCR, digital droplet PCR and advanced techniques, mutation detection and genetic analysis, fragment analysis and genotyping, Sanger sequencing and DNA sequencing, CLIA and molecular testing standards, and personalized medicine based on pharmacogenomics.
• Pharmacogenetics & Pharmacogenomics: genetic variation in drug metabolism and response, cytochrome P450 genetic polymorphisms, drug transporter genetic variation, gene-drug interactions and personalized dosing, pharmacogenomic biomarkers and predictive testing, ethnicity and population-specific pharmacogenomics, and precision medicine and individualized therapy.
• Clinical Trials & Drug Development: phases of clinical trials and study design, pharmacovigilance in clinical trial settings, protocol development and regulatory requirements, drug approval process and regulatory pathways, trial recruitment and patient selection, ethics in clinical research and informed consent, adverse event monitoring in trials, and efficacy and safety outcomes in clinical development.
• Drug-Drug & Drug-Gene Interactions: drug-drug interaction mechanisms and prediction, cytochrome P450-mediated interactions, transporter-mediated interactions and competitive inhibition, pharmacokinetic and pharmacodynamic interactions, drug-nutrient interactions and food effects, genetic polymorphisms affecting drug interactions, and clinical management of significant interactions.
• Endocrine Pharmacology & Hormonal Therapy: endocrine drug mechanisms and therapeutic effects, hormone replacement therapy and hormone agonists, hormone antagonists and receptor blockers, regulatory studies in endocrine pharmacology, safety pharmacology endpoints, organ weight changes and endocrine effects, organ function testing and assessment, and endocrine outcomes and therapeutic efficacy.