Small proteins' function in cellular energy management
This special issue belongs to
|International Journal of Cell Biology and Cellular Processes
Deadline for Manuscript Submission
|March 31st, 2022
Deadline for Publication
|April 15, 2022
Special Issue Description
New molecular information on how cells make sure that their energy supply is regulated to meet energy demand has been found by researchers at Duke-NUS Medical School. Their study, which was conducted in collaboration with scientists from Duke University in Durham, North Carolina, and the University of Melbourne in Australia, emphasizes the critical role microproteins play in the assembly of larger protein complexes inside mitochondria, the energy-producing cell components. Numerous disorders, including common conditions like heart failure, obesity, diabetes, and cancer, are characterized by mitochondrial dysfunction. The double membrane that surrounds mitochondria—often referred to as the cell's powerhouses—defines its boundaries.
An array of proteins that are part of the electron transport chain are found in the inner of the two membranes. The activities that take chemical energy from food sources and ultimately store it in adenosine triphosphate molecules, which are energy-rich, depend on this electron transport (ATP). The new information from the Duke-NUS cooperation demonstrates that small microproteins also referred to as peptides are essential for the development of the electron transport chain. They specifically appear to work together to facilitate and control the assembly of Complex III, one of the chain's essential proteins. This activity permits the microproteins to participate in regulating the concentrations of the electron transport chain proteins and, subsequently, the energy supply in response to changes in energy demand.
* Electron transport chain
* Heart failure
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