Open Access   Special Issue    Topic

Small proteins' function in cellular energy management

  • Special Issue Description
  • Keywords
  • Manuscript Submission information
  • Published Articles
  •   This special issue belongs to

      International Journal of Cell Biology and Cellular Processes

      Related section


      Deadline for Manuscript Submission

      March 31st, 2022

      Deadline for Publication

      April 15, 2022

    Special Issue Description

    Dear Collegues,

    New molecular information on how cells make sure that their energy supply is regulated to meet energy demand has been found by researchers at Duke-NUS Medical School. Their study, which was conducted in collaboration with scientists from Duke University in Durham, North Carolina, and the University of Melbourne in Australia, emphasizes the critical role microproteins play in the assembly of larger protein complexes inside mitochondria, the energy-producing cell components. Numerous disorders, including common conditions like heart failure, obesity, diabetes, and cancer, are characterized by mitochondrial dysfunction. The double membrane that surrounds mitochondria—often referred to as the cell's powerhouses—defines its boundaries.

    An array of proteins that are part of the electron transport chain are found in the inner of the two membranes. The activities that take chemical energy from food sources and ultimately store it in adenosine triphosphate molecules, which are energy-rich, depend on this electron transport (ATP). The new information from the Duke-NUS cooperation demonstrates that small microproteins also referred to as peptides are essential for the development of the electron transport chain. They specifically appear to work together to facilitate and control the assembly of Complex III, one of the chain's essential proteins. This activity permits the microproteins to participate in regulating the concentrations of the electron transport chain proteins and, subsequently, the energy supply in response to changes in energy demand.


    * ATP
    * Electron transport chain
    * Heart failure
    * Mitochondria
    * Microproteins

    Manuscript Submission information

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    Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent on email address:[email protected] for announcement on this website.
    Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.

    Published articles

    "This special issue is now open for submission."