Recent advancements in plant cell culture
This special issue belongs to
|International Journal of Plant Biotechnology|
Deadline for Manuscript Submission
|March 31st, 2022|
Deadline for Publication
|April 15, 2022|
Special Issue Description
Initial research focused on using plant cell culture systems for the commercial synthesis of several high-value secondary metabolites. This allowed for sustainable production that was not constrained by the low yields associated with natural harvest or the high cost associated with complex chemical synthesis. Despite certain commercial achievements, most notably the manufacture of paclitaxel from Taxus sp., there are still process limits due to low product yields and intrinsic production unpredictability. To get around these restrictions, several techniques are being developed, such as elicitation, in situ product removal, and metabolic engineering using single genes and transcription factors. Heterologous proteins with medicinal activity have recently been added to the plant cell culture production platform.
Plant-based manufacturing methods are advantageous because they can generate complex proteins that are correctly folded, glycosylated, and assembled without running the danger of being contaminated by toxins common to mammalian or microbial production methods. Furthermore, compared to field-grown crops, plant cell culture isolates transgenic material from the environment, allows for better-controlled conditions, and encourages the secretion of proteins into the medium, which lowers the cost of subsequent purification. Despite these advantages, heterologous protein synthesis in plant cell culture is significantly more expensive than it is in field-grown crops. As a result, processes must be improved to maximize secretion and improve protein stability in cell culture conditions.
* Cell culture
* Heterologous proteins
* Secondary metabolites
* Protein stability
* Cell culture conditions.
Manuscript Submission information
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Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent on email address:[email protected] for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.