Open Access   Special Issue    Topic

Pharmacological targets that are suitable for treating Genomic disorders

  • Special Issue Description
  • Keywords
  • Manuscript Submission information
  • Published Articles
  •   This special issue belongs to

      Trends in Drug Delivery Special Issues

      Related section

       NA

      Deadline for Manuscript Submission

      March 31st, 2023

      Deadline for Publication

      April 15, 2023

    Special Issue Description


    Dear Collegues,



    The determination of pharmacological targets is a crucial phase in the drug design process in the biomedical field. Therefore, it is tempting to also use this model to describe genetic diseases. Although the model works well for genetic disorders with gain-of-function, it is less effective for the majority of genetic diseases with loss of function. The majority of common diseases, along with hereditary diseases with gain-of-function, are defined by the activation of particular pathways or the ectopic activity of proteins, which make excellent targets.

    On the other hand, loss-of-function genetic illnesses are brought on by the deficiency of a single protein and may have widespread effects. It may be challenging to identify pharmaceutically relevant targets for such disorders since the concept of a pharmacological target is less exact. To prevent allocating resources to ineffective techniques in the search for cures, it is important to take into account this important but usually overlooked element of loss-of-function genetic illnesses.

    Keywords

    * Genetic diseases
    * target-based drug design
    * malfunction
    * enzyme encoding genes
    * Phenotype

    Manuscript Submission information


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    Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent on email address:[email protected] for announcement on this website.
    Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.

    Published articles

    "This special issue is now open for submission."