Novel inhalation formulations of optimyxin
This special issue belongs to
|Research & Reviews: A Journal of Pharmacology|
Deadline for Manuscript Submission
|March 31st, 2023|
Deadline for Publication
|April 15, 2023|
Special Issue Description
Due to bacterial resistance and limited drug exposure at the infection site, intravenous and oral antibiotics are not usually effective for treating lung infections.
A novel optimyxin combo medication has been created by Purdue University researchers to treat bacterial lung infections. Infections brought on by multi-drug resistant Gram-negative "superbugs" have frequently been treated with optimyxin as a last resort; nevertheless, inhaled optimyxin can be harmful to the lungs.
In comparison to the commonly used breathed optimyxin B and colistin, the novel formulations created by Purdue researchers create a potent therapeutic option with superior antibacterial killing and much-reduced toxicity. The Purdue dry powder formulation, which exhibits good stability and strong aerosolization capability, also shows potential as an inhaled treatment.
Dry powder inhaler
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