Open Access   Special Issue    Topic

Mechanism and Health effects of toxic chemicals and heavy metals

  • Special Issue Description
  • Keywords
  • Manuscript Submission information
  • Published Articles
  •   This special issue belongs to

      Research & Reviews: A Journal of Toxicology

      Related section


      Deadline for Manuscript Submission

      March 31st, 2023

      Deadline for Publication

      April 15, 2023

    Special Issue Description

    Dear Collegues,

    The earth's crust contains several naturally occurring heavy metals that are used for a variety of industrial and commercial purposes. A number of these heavy metals affect the human body, either directly or indirectly. Some of these heavy metals, including copper, cobalt, iron, nickel, magnesium, molybdenum, chromium, selenium, manganese, and zinc, have functional functions that are crucial for a variety of physiological and biochemical processes in the body. While others, including cadmium, mercury, lead, chromium, silver, and arsenic, have dramatic effects on the body and cause acute and chronic toxicities in people, some of these heavy metals can be hazardous to the body in high concentrations. Further, global public health is also at risk from exposure to some toxic chemicals like pesticides, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and perfluorooctanoic acids (PFOAs), which are linked to several diseases and harm social activities and economic growth.

    Through a variety of exposure pathways, such as oral, dermal, and occupational exposure, people can be exposed to combinations of chemical and metal poisons simultaneously and/or sequentially. By interfering with the endocrine system, breaking DNA, harming tissues, and activating or inactivating genes, exposure to these chemicals and metals has been linked to several diseases, including cancers. Additionally, exposure to hazardous substances at work and in the environment increases the global burden of disease, which annually results in 90 million years of disability-adjusted life expectancy (DALYs) and nearly 5 million fatalities. However, the quantification of exposure dose (e.g., duration, frequency, model, and intensity), the effects of chemical and metal mixtures (e.g., additive, synergistic, or antagonistic), and the toxicological interactions of toxic chemicals are currently limiting the health risk assessment of cumulative exposure to toxic chemicals and heavy metals.

    To more accurately assess, monitor, and mitigate health risks brought on by exposures to chemical toxins and molecular mechanisms of heavy metal intoxication, which involve attaching to proteins and enzymes, changing their function, and inflicting harm, this special issue intends to compile research papers as well as critical reviews that address concerns relating to chemical toxicology, public health and described how heavy metals cause neurotoxicity, create free radicals that encourage oxidative stress, and damage lipids, proteins, and DNA molecules, and how these free radicals promote carcinogenesis. The harmful health impacts of these heavy metals are explained along with their mechanisms.


    * Molecular Mechanism
    * Heavy Metals
    * Chemical Toxins
    * Free radicals
    * Carcinogenesis

    Manuscript Submission information

    Manuscripts should be submitted online by registering and logging in to this link. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed.
    Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent on email address:[email protected] for announcement on this website.
    Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.

    Published articles

    "This special issue is now open for submission."