Open Access   Special Issue    Topic

Lysosome-based drug-delivery

  • Special Issue Description
  • Keywords
  • Manuscript Submission information
  • Published Articles
    •

      This special issue belongs to

    		   Trends in Drug Delivery Special Issues

      Related section

    		    NA

      Deadline for Manuscript Submission

    		   March 31st, 2023

      Deadline for Publication

    		  April 15, 2023

    Special Issue Description


    Dear Collegues,



    Lysosomes are membrane-enclosed organelles that contain an array of enzymes capable of breaking down all types of biological polymers—proteins, nucleic acids, carbohydrates, and lipids. The outflow of the byproducts of intralysosomal catabolism is facilitated by their physiological function. With rare exceptions, these porters are uncommon candidates for the translocation of xenobiotics across the lysosome membrane due to their specialization. Passive diffusion is most likely to be used to achieve efflux from the lysosome where it is possible.

    Experimental investigations of passive diffusion over the lysosome membrane have revealed that it shares many properties with other biological membranes. When drug delivery options are considered that involve a drug-conjugate reaching the lysosome compartment and drug release there by the lysosomal enzymes, predictions of how easily molecules will pass through lysosomal membranes are valuable. These methods won't work if the medication can't exit the lysosome and get to the cells where it needs to act pharmacologically

    Keywords

    * Lysosome therapeutics
    * Drug delivery
    * Bioavailability
    * Lysosome manufacturing
    * Molecular engineering

    Manuscript Submission information


    Manuscripts should be submitted online by registering and logging in to this link. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed.
    Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent on email address:[email protected] for announcement on this website.
    Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.

    Published articles

    "This special issue is now open for submission."

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