Anti-Inflammatory drug delivery of Neurodegenerative disease
This special issue belongs to
|Trends in Drug Delivery Special Issues
Deadline for Manuscript Submission
|March 31st, 2023
Deadline for Publication
|April 15, 2023
Special Issue Description
The immune system's biological response to an irritant is inflammation, which serves to defend living things from harm. However, excessive and unchecked inflammation is linked to several deadly Neurodegenerative disorders, such as Alzheimer's, Dementia, Huntington's disease, etc. A wide range of anti-inflammatory therapies are now available for the treatment and management of pertinent chronic diseases thanks to advances in our understanding of the inflammatory response. Despite these achievements, patients' clinical outcomes vary, and major side effects are frequently reported.
Additionally, there are some restrictions for clinical anti-inflammatory therapies, including inadequate access to subcellular compartments, low bioavailability, off-target effects, and water insolubility. The rational design of inflammation-specific drug delivery systems (DDSs) offers tremendous potential for overcoming these difficulties. Additionally, compared to normal tissues, the pathological milieu associated with inflamed tissues (such as oxidative stress, an acidic pH, and overexpressed enzymes) offers crucial biochemical triggers for the triggered administration of anti-inflammatory drugs in a spatiotemporally regulated way. For the treatment of neuroinflammatory illnesses, we highlight current developments in the creation of anti-inflammatory DDSs with an integrated pathological inflammation-specific response.
* Anti-Inflammatory agents
* Drug delivery system
* Stimuli-responsive polymers
Manuscript Submission information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.