Research & Reviews : Journal of Medical Science and Technology

ISSN: 2319-3417

Editors Overview

rrjomst maintains an Editorial Board of practicing researchers from around the world, to ensure manuscripts are handled by editors who are experts in the field of study.

Open Access
Special Issue
Topic

Pathophysiology of Renal erythropoietin- cells

Abstract Submission Deadline : November 30, 2023

Manuscript Submission Deadline : December 25, 2023

Special Issue Description

Chronic kidney illness (CKD) is an issue all over the world with expanding rate and prevalence. Iron deficiency, a well-known complication in CKD, is more visits in patients with lower glomerular filtration rates, particularly those with end-stage renal disease (ESRD) requiring long-term dialysis. Given that renal iron deficiency unfavorably influences the quality of life and is related to destitute results in CKD. Erythropoietin (EPO), a glycoprotein hormone, is the ace controller of erythropoiesis. Later progresses in understanding the physiology and pathophysiology of renal EPO-producing cells (REPCs) give openings to find novel medications by upgrading oxygen detecting instruments and epigenetic modification. Anemia may be a common complication and contributes to expanded horribleness and mortality in constant kidney infection (CKD) patients. Though there has been a noteworthy enhancement in of understanding the fundamental component of erythropoiesis, the treatment of renal frailty is still confined to erythropoietin (EPO)-stimulating operators. The physiology of erythropoiesis, a useful part of EPO, and the fundamental atomic and cellular premise that directs EPO generation. In CKD, plasma EPO level is out of the extent to the degree of anemia. In CKD, pericytes transdifferentiate to myofibroblasts, and hence the capacity of EPO generation diminishes, driving renal iron deficiency. Later exploratory and clinical considerations appear to the promising viability of prolyl hydroxylase inhibitors in renal iron deficiency through expanding EPO generation by stabilizing hypoxia-inducible factor (HIF).

Keywords

Chronic kidney illness (CKD), End-stage renal disease (ESRD), Erythropoietin (EPO), Renal EPO-producing cells (REPCs), Epigenetic, Anemia, Hypoxia-inducible factor (HIF)

Manuscript Submission information

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