Research & Reviews: Journal of Oncology and Hematology

ISSN: 2319-3387

Editors Overview

rrjooh maintains an Editorial Board of practicing researchers from around the world, to ensure manuscripts are handled by editors who are experts in the field of study.

Open Access
Special Issue
Topic

Future aspects of vascular biology

Abstract Submission Deadline : November 30, 2023

Manuscript Submission Deadline : December 25, 2023

Special Issue Description

All of the organs and tissues in our body need to develop and operate properly, and the vascular system is one of the first to form during embryogenesis. Our understanding of the biology of blood vessels and the pathobiology of local and systemic vascular disease states has advanced over the past several decades as a result of pivotal discoveries in the field of vascular biology, which have also resulted in novel disease-modifying treatments for patients. When Furchgott and Zawadzki discovered endothelium-derived nitric oxide and its effects on vascular tone in 1980, they fundamentally altered our focus on blood vessel research. This ground-breaking discovery redefined blood arteries as active, self-regulating organs having endocrine, paracrine, and autocrine capabilities.Following this, vascular biology research mainly focused on three aspects of vascular function: vasomotor tone, inflammation, and the equilibrium between thrombosis and thrombolysis. This happened as a result of the pandemic levels of atherosclerotic cardiovascular disease and the discovery that atherothrombosis included disruptions in these functions that appeared before the illness’s clinical and pathological signs. The importance of preclinical vascular biology research in the treatment of hypertension, atherosclerosis, pulmonary vascular disease, erectile dysfunction, Raynaud phenomenon, and neointimal proliferation following mechanical vascular intervention is also beginning to be supported by clinical studies. Modification of the responsible causal factors also reversed impaired vascular function (e.g., lower levels of low-density lipoproteins in atherosclerosis). More recent in vitro and in vivo studies have shown that blood vessels regulate their redox milieu, metabolism, mechanical environment, and phenotype, in part through complex interactions between cellular components of the blood vessel wall and circulating factors. These studies were made possible by advances in molecular biology and -omics technologies. These interactors include hormones, proteins, and lipids as well as stem, progenitor, and differentiated cells; microRNAs; long noncoding RNAs; and DNA. The mechanism by which risk factors for cardiopulmonary vascular disease lead to vascular dysfunction, structural remodeling, and ultimately adverse clinical events such as myocardial infarction, stroke, critical limb ischemia, and pulmonary hypertension has also been implicated as dysregulation of these carefully regulated homeostatic interactions

Keywords

Cardiovascular, Cardiopulmonary vascular diseases, Blood Vessels, MicroRNA, Stem cells

Manuscript Submission information

Manuscripts should be submitted online via the manuscript Engine. Once you register on APID, click here to go to the submission form. Manuscripts can be submitted until the deadline.
All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the email address:[email protected] for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a Double-blind peer-review process. A guide for authors and other relevant information for the submission of manuscripts is available on the Instructions for Authors page.

Participating journals: