Research & Reviews: A Journal of Pharmacology

ISSN: 2230-9861

Editors Overview

rrjop maintains an Editorial Board of practicing researchers from around the world, to ensure manuscripts are handled by editors who are experts in the field of study.

Open Access
Special Issue
Topic

Efficacy of a Three Drug-Based Therapy for Neuroblastoma in frog

Abstract Submission Deadline : November 30, 2023

Manuscript Submission Deadline : December 25, 2023

Special Issue Description

As far as childhood tumors go, high-risk neuroblastoma (HR-NB) is still the most hazardous. The discovery of novel therapeutic modalities is of utmost significance. Recently, we combined fendiline hydrochloride, an inhibitor of several transporters involved in the multidrug resistance of cancer cells, with the traditional pharmacological approach to NB, represented by cisplatin, and found that this combination increased the ability of cisplatin to induce apoptosis. To find a new and more effective treatment for SKNBE2 xenografts in NOD-SCID mice, we co-administered acetazolamide, a carbonic anhydrase isoform IX (CAIX) inhibitor that has been shown to boost chemotherapy efficacy in a variety of cancer types. The discrepancies in the three medications rise more than twelvefold when taken together, according to our research.

Keywords

Neuroblastoma, Fendiline hydrochloride, Acetazolamide , Drug repositioning, CAIX, Non-coding

Manuscript Submission information

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