Mohammad Nadeem Khan
Ashok Kumar
Praveen Chand Dubey
Mohammad Rafi
Abstract
Nutraceuticals are a broad category of palatable natural chemicals that are thought to offer benefits beyond their nutritional content. These can include foods high in nutrients, foods with therapeutic properties, or certain ingredients found in some foods, like dietary fiber, hydrolyzed protein, garlic, ginger, omega-3, soybean, minerals, vitamins, fortified foods, enriched foods, and even recombinant goods. People are becoming more concerned about their health due to the long work hours and psychological strains of the modern lifestyle, which is causing a rise in life-threatening illnesses. Nutraceuticals are categorized according to their type and mechanism of action. The several kinds of nutraceuticals and their possible anti-cancer, antioxidant, anti-inflammatory, and anti-lipid qualities are examined in this review along with their potential therapeutic uses against cancer. The conversation covers various modes of action, uses, consumer safety concerns, as well as present and potential trends in the nutraceutical industry
Keywords: Nutrient, food supplement, probiotics, Anti-oxidant, well-being, life style, hypertension
[This article belongs to Recent Trends in Infectious Diseases(rtid)]
References
REFERENCES
Misra LN. Traditional phytomedicinal systems, scientific validations and current popularity as nutraceuticals. Int J Trad Nat Med. 2013;2:27-75.
Helal NA, Eassa HA, Amer AM, Eltokhy MA, Edafiogho I, Nounou MI. Nutraceuticals’ novel formulations: the good, the bad, the unknown and patents involved. Recent patents on drug delivery & formulation. 2019 Jun 1;13(2):105-56.
Petrovska BB. Historical review of medicinal plants’ usage. Pharmacognosy reviews. 2012 Jan;6(11):1.
Nasri H, Baradaran A, Shirzad H, Rafieian-Kopaei M. New concepts in nutraceuticals as alternative for pharmaceuticals. International journal of preventive medicine. 2014 Dec;5(12):1487.
Caramia G, Silvi S. Probiotics: from the ancient wisdom to the actual therapeutical and nutraceutical perspective. Probiotic Bacteria and Enteric Infections: Cytoprotection by Probiotic Bacteria. 2011:3-7.
Ried K. Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: an updated meta-analysis and review. The Journal of nutrition. 2016 Feb 1;146(2):389S-96S.
Affuso F, Ruvolo A, Micillo F, Sacca L, Fazio S. Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study. Nutrition, Metabolism and Cardiovascular Diseases. 2010 Nov 1;20(9):656-61.
Chen GL, Chen SG, Chen FU, Xie YQ, Han MD, Luo CX, Zhao YY, Gao YQ. Nutraceutical potential and antioxidant benefits of selected fruit seeds subjected to an in vitro digestion. Journal of Functional Foods. 2016 Jan 1;20:317-31.
Pitchaiah G, Akula A, Chandi V. Anticancer potential of nutraceutical formulations in MNU-induced mammary cancer in Sprague Dawley rats. Pharmacognosy magazine. 2017 Jan;13(49):46.
AlAli M, Alqubaisy M, Aljaafari MN, AlAli AO, Baqais L, Molouki A, Abushelaibi A, Lai KS, Lim SH. Nutraceuticals: Transformation of conventional foods into health promoters/disease preventers and safety considerations. Molecules. 2021 Apr 27;26(9):2540.
Chaplin DD. Overview of the immune response. Journal of allergy and clinical immunology. 2010 Feb 1;125(2):S3-23.
Ruchi S. Role of nutraceuticals in health care: A review. International Journal of Green Pharmacy (IJGP). 2017 Oct 16;11(03).
Paul WE. Fundamental immunology. Lippincott Williams & Wilkins; 2012 Dec 3.
Singh J, Sinha S. Classification, regulatory acts and applications of nutraceuticals for health. International Journal of Pharma and Bio Sciences. 2012;2(1):177-87.
Scrinis G. Functional foods or functionally marketed foods? A critique of, and alternatives to, the category of ‘functional foods’. Public health nutrition. 2008 May;11(5):541-5.
Prabu SL, SuriyaPrakash TN, Kumar CD, SureshKumar S, Ragavendran T. Nutraceuticals: A review. Elixir Pharm. 2012 Apr 25;46:8372-7.
Kumar KS, Paswan S, Srivastava S. Tomato-a natural medicine and its health benefits. Journal of Pharmacognosy and Phytochemistry. 2012;1(1):33-43.
Singh B, Singh JP, Singh N, Kaur A. Saponins in pulses and their health promoting activities: A review. Food Chemistry. 2017 Oct 15;233:540-9.
Smith KL, Guentzel JL. Mercury concentrations and omega-3 fatty acids in fish and shrimp: preferential consumption for maximum health benefits. Marine pollution bulletin. 2010 Sep 1;60(9):1615-8.
Maurya S, Sharma N, Tiwari M, Singh A, Singh S, Yadav K. A review article on nutraceuticals. Int Res J Modernizat Eng Technol Sci. 2022.
Alkhatib A, Tsang C, Tiss A, Bahorun T, Arefanian H, Barake R, Khadir A, Tuomilehto J. Functional foods and lifestyle approaches for diabetes prevention and management. Nutrients. 2017 Dec 1;9(12):1310.
Lau TC, Chan MW, Tan HP, Kwek CL. Functional food: a growing trend among the health conscious. Asian Social Science. 2013 Jan 1;9(1):198.
Morledge R, Smith AJ, Appiah SY. Building procurement. John Wiley & Sons; 2021 Apr 12.
Sikand G, Kris-Etherton P, Boulos NM. Impact of functional foods on prevention of cardiovascular disease and diabetes. Current cardiology reports. 2015 Jun;17:1-6.
Umadevi M, Pushpa R, Sampathkumar KP, Bhowmik D. Rice-traditional medicinal plant in India. Journal of pharmacognosy and phytochemistry. 2012;1(1):06-12.
Bhat FM, Riar CS. Health benefits of traditional rice varieties of temperate regions. Med. Aromat. Plants. 2015;4:198.
Stevenson LE, Phillips F, O’sullivan K, Walton J. Wheat bran: its composition and benefits to health, a European perspective. International journal of food sciences and nutrition. 2012 Dec 1;63(8):1001-13.
Prueckler M, Siebenhandl-Ehn S, Apprich S, Hoeltinger S, Haas C, Schmid E, Kneifel W. Wheat bran-based biorefinery 1: Composition of wheat bran and strategies of functionalization. LWT-Food Science and Technology. 2014 May 1;56(2):211-21.
Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy reviews. 2010 Jul;4(8):118.
El Sohaimy SA. Functional foods and nutraceuticals-modern approach to food science. World Applied Sciences Journal. 2012;20(5):691-708.
Hasler CM. Functional foods: benefits, concerns and challenges—a position paper from the American Council on Science and Health. The Journal of nutrition. 2002 Dec 1;132(12):3772-81.
Dey P, Bruno RS. Green Tea Catechins and Nonalcoholic Fatty Liver Disease. Dietary Supplements with Antioxidant Activity: Understanding Mechanisms and Potential Health Benefits: Dietary Supplements with Antioxidant Activity: Understanding Mechanisms and Potential Health Benefits. 2023 Jun 9:92.
Lee Y, Hu S, Park YK, Lee JY. Health benefits of carotenoids: a role of carotenoids in the prevention of non-alcoholic fatty liver disease. Preventive nutrition and food science. 2019 Jun;24(2):103
Shardell MD, Alley DE, Hicks GE, El-Kamary SS, Miller RR, Semba RD, Ferrucci L. Low-serum carotenoid concentrations and carotenoid interactions predict mortality in US adults: the Third National Health and Nutrition Examination Survey. Nutrition research. 2011 Mar 1;31(3):178-89.
Eggersdorfer M, Wyss A. Carotenoids in human nutrition and health. Archives of biochemistry and biophysics. 2018 Aug 15;652:18-26.
Cheng HM, Koutsidis G, Lodge JK, Ashor AW, Siervo M, Lara J. Lycopene and tomato and risk of cardiovascular diseases: A systematic review and meta-analysis of epidemiological evidence. Critical reviews in food science and nutrition. 2019 Jan 2;59(1):141-58..
Chew EY, Clemons TE, SanGiovanni JP, Danis RP, Ferris FL, Elman MJ, Antoszyk AN, Ruby AJ, Orth D, Bressler SB, Fish GE. Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3. JAMA ophthalmology. 2014 Feb 1;132(2):142-9.
Walk AM, Khan NA, Barnett SM, Raine LB, Kramer AF, Cohen NJ, Moulton CJ, Renzi-Hammond LM, Hammond BR, Hillman CH. From neuro-pigments to neural efficiency: The relationship between retinal carotenoids and behavioral and neuroelectric indices of cognitive control in childhood. International Journal of Psychophysiology. 2017 Aug 1;118:1-8.
Kang H, Kim H. Astaxanthin and β-carotene in Helicobacter pylori-induced Gastric Inflammation: A Mini-review on Action Mechanisms. Journal of cancer prevention. 2017 Jun;22(2):57.
Young AJ, Lowe GL. Carotenoids—antioxidant properties. Antioxidants. 2018 Feb 11;7(2):28.
Gómez-Guillén MC, Giménez B, López-Caballero MA, Montero MP. Functional and bioactive properties of collagen and gelatin from alternative sources: A review. Food hydrocolloids. 2011 Dec 1;25(8):1813-27.
Song H, Li B. Beneficial effects of collagen hydrolysate: A review on recent developments. Biomed. J. Sci. Tech. Res. 2017;1:458-61.
Fan J, Zhuang Y, Li B. Effects of collagen and collagen hydrolysate from jellyfish umbrella on histological and immunity changes of mice photoaging. Nutrients. 2013 Jan 17;5(1):223-33.
Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity, and wrinkling in human skin: a randomized, double-blind, placebo-controlled study. Nutrients. 2018 Jun 26;10(7):826.
Gidley MJ, Yakubov GE. Functional categorisation of dietary fibre in foods: Beyond ‘soluble’vs ‘insoluble’. Trends in Food Science & Technology. 2019 Apr 1;86:563-8.
McRorie Jr JW, McKeown NM. Understanding the physics of functional fibers in the gastrointestinal tract: an evidence-based approach to resolving enduring misconceptions about insoluble and soluble fiber. Journal of the Academy of Nutrition and Dietetics. 2017 Feb 1;117(2):251-64.
Petiwala SM, Johnson JJ. Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity. Cancer letters. 2015 Oct 28;367(2):93-102.
Vinothkumar V, Manoharan S, Sindhu G, Nirmal MR, Vetrichelvi V. Geraniol modulates cell proliferation, apoptosis, inflammation, and angiogenesis during 7, 12-dimethylbenz [a] anthracene-induced hamster buccal pouch carcinogenesis. Molecular and cellular biochemistry. 2012 Oct;369:17-25.
Nair HB, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB. Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer. Biochemical pharmacology. 2010 Dec 15;80(12):1833-43.
Al-Okbi SY. Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis. Toxicology and industrial health. 2014 Sep;30(8):738-49.
Vecchione R, Quagliariello V, Calabria D, Calcagno V, De Luca E, Iaffaioli RV, Netti PA. Curcumin bioavailability from oil in water nano-emulsions: In vitro and in vivo study on the dimensional, compositional and interactional dependence. Journal of Controlled Release. 2016 Jul 10;233:88-100.
Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, Aggarwal BB. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. British journal of pharmacology. 2017 Jun;174(11):1325-48.
| Volume | 01 |
| Issue | 01 |
| Received | November 23, 2023 |
| Accepted | December 4, 2023 |
| Published | December 27, 2023 |