Biokinetics of Retention and Dose Delivery to Body Organs due to Protracted Ingestion of Natural Uranium in Groundwater of Patiala District, Punjab, India

Year : 2024 | Volume :14 | Issue : 03 | Page : 1-15
By

Hardev Singh Virk,

  1. Professor, Department of Eminence in Physics (Honorary), Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab, India

Abstract

This study pertains to the uranium concentration in the drinking water and its biokinetics of the retention and dose delivered to body organs of the residents of 50 villages of the Patiala district of the Punjab State where U content is higher than the safe limit of 30 ppb fixed by WHO. U content values vary from 38.0 µg/L (Uppli) to 267.0 µg/L (Ahru Kalan) with an average value of 68.70 µg/L. Li’s Hair Biokinetic Model of uranium has been used to calculate the dose delivered to different body organs due to ingestion of uranium. The dose delivered is related to retention of uranium in human body. The maximum dose is delivered to bone walls followed by kidneys. The dose delivered to several other organs like adrenals, bladder wall, lung, pancreas, skin, spleen, thymus, and thyroid remains the same. For dose delivery and retention, this model makes some assumptions, for example, the water consumption rate is 1.4 L/day for the average lifetime of 60 years. The daily intake of uranium from the drinking water for the residents of the study area is found to vary from 53.2 μg day–1 to 373.8 μg day–1. The average uranium ingestion rate is estimated to be 96.18 μg day–1 for the whole life exposure of 60 years. The retention of uranium is estimated to be maximum for the cortical bone volume followed by OST. The excretion rate of uranium is found to be maximum via faeces, followed by hair and urine. It is called Li’s Hair Compartment Model as excretion via hair has been used as medium for the first time by Li.

Keywords: Groundwater, Patiala district, uranium, biokinetic model, dose assessment

[This article belongs to Research & Reviews: A Journal of Toxicology (rrjot)]

How to cite this article:
Hardev Singh Virk. Biokinetics of Retention and Dose Delivery to Body Organs due to Protracted Ingestion of Natural Uranium in Groundwater of Patiala District, Punjab, India. Research & Reviews: A Journal of Toxicology. 2024; 14(03):1-15.
How to cite this URL:
Hardev Singh Virk. Biokinetics of Retention and Dose Delivery to Body Organs due to Protracted Ingestion of Natural Uranium in Groundwater of Patiala District, Punjab, India. Research & Reviews: A Journal of Toxicology. 2024; 14(03):1-15. Available from: https://journals.stmjournals.com/rrjot/article=2024/view=176243

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Regular Issue Subscription Review Article
Volume 14
Issue 03
Received 07/08/2024
Accepted 09/09/2024
Published 28/09/2024
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