Padma Latha,
N. Jyothi Reddy,
Sd Riaz Hussain,
S. Deepa,
- Professor Department of Pharmaceutical Analysis & Chemistry, Gyana Jyothi College of Pharmacy, Telangana India
- Associate Professor Department of Pharmaceutical Analysis & Chemistry, Gyana Jyothi College of Pharmacy Telangana India
- Assistant professor Department of Pharmaceutical Analysis & Chemistry, Gyana Jyothi College of Pharmacy Telangana India
- Assistant professor Department of Pharmaceutical Analysis & Chemistry, Gyana Jyothi College of Pharmacy Telangana India
Abstract
The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals were embedded within the buccal flim for sustained release of the drug. The buccal film was optimized by Factorial design using HPMC and PVA as independent variables. Two responses were chosen such as Drug permeation and Mucoadhesive strength for optimizing the buccal flim. Based on desirability value (1.00) the formulation factors were found and observed value is closer to the predicted values. This results reveals that the model is validated. The morphology of buccal flim was charactarized with SEM analysis. The buccal flim was tested for Thickness, weight variation, Folding Endurance, Drug content, Moisture loss, Surface pH and Swelling studies. The drug permeation kinetic study was performed in the optimized formulation and the results reveals that the mechanism of drug permeation follows diffusion from higher r2 value for Higuchi kinetics (r2 = 0.992) and the n value of peppas model (n=0.653) shows that the mechanism follows Non-Fickian diffusion. Novel Buccal adhesive cocrystal embedded patch offers innumerable advantages. While the water solubility of the drug is improved by 2 folds so that the permeation efficacy of the drug also improved, aided by increased bioavailability. Buccal patch exerts many advantages like ease of administration and withdrawal, avoiding first pass metabolism, low enzyme activity, enhancement of permeability and high patient compliance. Hence the novel formulation holds immense opportunities to be explored in terms of different drug candidates.
Keywords: Optimization, Evaluation, Felodipine Co-Crystals, Buccal Film, Bioavailability
[This article belongs to Research & Reviews: A Journal of Toxicology(rrjot)]
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Research & Reviews: A Journal of Toxicology
| Volume | 14 |
| Issue | 02 |
| Received | March 26, 2024 |
| Accepted | April 6, 2024 |
| Published | July 20, 2024 |