[{“box”:0,”content”:”[if 992 equals=”Open Access”]n
n
Open Access
nn
n
n[/if 992]n
n
n
n
n
n
Padma Latha, N. Jyothi Reddy, Sd Riaz Hussain, S. Deepa,
n
- n t
n
n
n[/foreach]
n
n[if 2099 not_equal=”Yes”]n
- [foreach 286] [if 1175 not_equal=””]n t
n[/if 1175][/foreach]
n[/if 2099][if 2099 equals=”Yes”][/if 2099]n
Abstract
nThe preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals were embedded within the buccal flim for sustained release of the drug. The buccal film was optimized by Factorial design using HPMC and PVA as independent variables. Two responses were chosen such as Drug permeation and Mucoadhesive strength for optimizing the buccal flim. Based on desirability value (1.00) the formulation factors were found and observed value is closer to the predicted values. This results reveals that the model is validated. The morphology of buccal flim was charactarized with SEM analysis. The buccal flim was tested for Thickness, weight variation, Folding Endurance, Drug content, Moisture loss, Surface pH and Swelling studies. The drug permeation kinetic study was performed in the optimized formulation and the results reveals that the mechanism of drug permeation follows diffusion from higher r2 value for Higuchi kinetics (r2 = 0.992) and the n value of peppas model (n=0.653) shows that the mechanism follows Non-Fickian diffusion. Novel Buccal adhesive cocrystal embedded patch offers innumerable advantages. While the water solubility of the drug is improved by 2 folds so that the permeation efficacy of the drug also improved, aided by increased bioavailability. Buccal patch exerts many advantages like ease of administration and withdrawal, avoiding first pass metabolism, low enzyme activity, enhancement of permeability and high patient compliance. Hence the novel formulation holds immense opportunities to be explored in terms of different drug candidates.
n
Keywords: Optimization, Evaluation, Felodipine Co-Crystals, Buccal Film, Bioavailability
n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Toxicology(rrjot)]
n
n
n
n
n
nn[if 992 equals=”Open Access”] Full Text PDF Download[/if 992] n
nn[if 379 not_equal=””]n
Browse Figures
n
n[/if 379]n
References
n[if 1104 equals=””]n
- Gupta H, Bhandari D, Sharma A. Recent trends in oral drug delivery: a review. Recent Pat. Drug Deliv. Formul. 2009;3:162–173.
- Akbari J, Nokhodchi A, Farid D, Adrangui M, Siahi-Shadbad MR, et al. (2004) Development and evaluation of buccoadhesive propranolol hydrochloride table formulations: Effect of fillers. Farmaco 59: 155-161.
- Remunan-Lopez C, Portero A, Vila-Jato JL, Alonso MJ (1998) Design and evaluation of chitosan/ethyl cellulose mucoadhesivebilayered devices for buccal drug delivery. J Control Release 55: 143-152.
- Rathborne M, Drummond B, Tucker I (1994) Oral cavity as a site for Systemic drug delivery. Adv Drug Deliv Rev 13: 1-22.
- Hao J, Heng PWS (2003) Buccal delivery systems. Drug Dev lnd Pharm 29: 821-832.
- Kurosaki Y, Kimura T (2000) Regional variation in oral mucosal drug permeability. Crit Rev Ther Drug Carrier Syst 17: 467-508.
- Gupta H, Bhandari D, Sharma A. Recent trends in oral drug delivery: a review. Recent Pat. Drug Deliv. Formul. 2009;3:162–173.
- Gupta AK, Mittal A, Jha K. Fast dissolving tablet – a review. Pharm. Innov. 2011;1:1–8. Available online on – WWW.IJIRMF.COM Page 139
- Shinde P, Salunkhe V, Magdum C.Buccal film:an innovative dosage form designed to improve patient compliance. Int. J of Pharmaceutical and Chemical science, 2012; 1(4):1262-1278.
- Nair AB, Kumaria R, Harsha S. In vitro techniques to evaluate buccal films. J of Controlled Release. 2013;166:10-21.
- Lee JW, Park JH, Robinson JR (2000) Bioadhesive-based dosage forms: the next generation. J Pharm Sci 89: 850-866.
- Veuillez F, Kalia YN, Jacques J, Deshusses, Buri P (2001) Factors and strategies for improving buccal absorption of peptides. Eur J Pharm Biopharm 51: 93-109.
- Liang AC, Chen L-LH. Fast-dissolving intraoral drug delivery systems. Expert Opin. Ther. Pat. 2001;11:981–986.
- Ketul P, Patel K, Patel M, Patel N. Fast dissolving films: a novel approach to oral drug delivery. IJPTP. 2013;4:655–661.
nn[/if 1104][if 1104 not_equal=””]n
- [foreach 1102]n t
- [if 1106 equals=””], [/if 1106][if 1106 not_equal=””],[/if 1106]
n[/foreach]
n[/if 1104]
nn
nn[if 1114 equals=”Yes”]n
n[/if 1114]
n
n
n
n
n
n
n
| Volume | 14 | |
| [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] | 02 | |
| Received | March 26, 2024 | |
| Accepted | April 6, 2024 | |
| Published | July 20, 2024 |
n
n
n
n
n
n nfunction myFunction2() {nvar x = document.getElementById(“browsefigure”);nif (x.style.display === “block”) {nx.style.display = “none”;n}nelse { x.style.display = “Block”; }n}ndocument.querySelector(“.prevBtn”).addEventListener(“click”, () => {nchangeSlides(-1);n});ndocument.querySelector(“.nextBtn”).addEventListener(“click”, () => {nchangeSlides(1);n});nvar slideIndex = 1;nshowSlides(slideIndex);nfunction changeSlides(n) {nshowSlides((slideIndex += n));n}nfunction currentSlide(n) {nshowSlides((slideIndex = n));n}nfunction showSlides(n) {nvar i;nvar slides = document.getElementsByClassName(“Slide”);nvar dots = document.getElementsByClassName(“Navdot”);nif (n > slides.length) { slideIndex = 1; }nif (n (item.style.display = “none”));nArray.from(dots).forEach(nitem => (item.className = item.className.replace(” selected”, “”))n);nslides[slideIndex – 1].style.display = “block”;ndots[slideIndex – 1].className += ” selected”;n}n”}]