Assessing the Efficacy of Carica Papaya Leaf Extract in Preventing Thrombocytopenia: A Review

Year : 2024 | Volume :11 | Issue : 02 | Page : 25-33
By

Devendra S Mahale,

Jagruti R. Girase,

Deveshree Yashwantbhai Patel,

Harsha Vasudev Chaudhari,

Patil Divyashree Kantilal,

Shraddha Pramod Amrutkar,

  1. Research Scholar Department of Pharmaceutics, P. S. G. V. P. Mandal’s college of pharmacy, shahada Maharashtra India
  2. Research Scholar Department of Pharmaceutics, P. S. G. V. P. Mandal’s college of pharmacy, shahada Maharashtra India
  3. Research Scholar Department of Pharmaceutics, P. S. G. V. P. Mandal’s college of pharmacy, shahada Maharashtra India
  4. Research Scholar Department of Pharmaceutics, P. S. G. V. P. Mandal’s college of pharmacy, shahada Maharashtra India
  5. Research Scholar Department of Pharmaceutics, P. S. G. V. P. Mandal’s college of pharmacy, shahada Maharashtra India
  6. Research Scholar Department of Pharmaceutics, P. S. G. V. P. Mandal’s college of pharmacy, shahada Maharashtra India

Abstract

A clinical condition known as thrombocytopenia is characterized by a low platelet count (less than 150 × 103/μL) in the blood, which leads to an imbalance in hemostasis and can result in multiple deadly consequences. Although the exact causes are not always known, they always lead to death by interfering with the formation of platelets and encouraging their destruction. Research demonstrates that Carica papaya leaf has special medicinal and therapeutic properties that help prevent thrombocytopenia. By promoting platelet formation, preventing platelet breakdown, and stopping viral proteases, secondary metabolites and minerals found in leaves like carpaine and quercetin, respectively, support platelet membrane integrity.Examining research conducted on animals and in clinical trials, this review investigates the scientific evidence supporting the protective effects of papaya leaf juice, extract, or powder against thrombocytopenia. Flavonoids, alkaloids, phenols, cardiac glycosides, tannins, terpenes, and saponins were found in the phytochemical profiles of C. papaya leaves, which give the leaf potential for medicinal use. Antiviral, antidiabetic, anticancer, antimalarial, antiangiogenic, antioxidant, and immunomodulatory properties are among the leaf’s medicinal advantages. A scientific study has demonstrated the effectiveness of C. papaya leaf against thrombocytopenia in multiple trials, extending the use of natural sources to treat a wide range of illnesses.

Keywords: Thrombocytopenia, immunomodulatory, antiangiogenic, Carica papaya, antibacterial activity.

[This article belongs to Research & Reviews: A Journal of Pharmacognosy(rrjopc)]

How to cite this article: Devendra S Mahale, Jagruti R. Girase, Deveshree Yashwantbhai Patel, Harsha Vasudev Chaudhari, Patil Divyashree Kantilal, Shraddha Pramod Amrutkar. Assessing the Efficacy of Carica Papaya Leaf Extract in Preventing Thrombocytopenia: A Review. Research & Reviews: A Journal of Pharmacognosy. 2024; 11(02):25-33.
How to cite this URL: Devendra S Mahale, Jagruti R. Girase, Deveshree Yashwantbhai Patel, Harsha Vasudev Chaudhari, Patil Divyashree Kantilal, Shraddha Pramod Amrutkar. Assessing the Efficacy of Carica Papaya Leaf Extract in Preventing Thrombocytopenia: A Review. Research & Reviews: A Journal of Pharmacognosy. 2024; 11(02):25-33. Available from: https://journals.stmjournals.com/rrjopc/article=2024/view=156162

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Regular Issue Subscription Review Article
Volume 11
Issue 02
Received April 8, 2024
Accepted July 1, 2024
Published July 12, 2024
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