Khyati Shah,
Anilkumar Mishra,
- Assistant Professor Shrimad Rajchandra College of Physiotherapy Gujarat India
- Professor Shrimad Rajchandra College of Physiotherapy Gujarat India
Abstract
It has long been known that blood pressure (BP) and cardiovascular morbidity are related. It is acknowledged that blood pressure during activity may serve as a more reliable indicator than resting blood pressure, which might not accurately reflect blood pressure at other times. Goals: 1) To assess how blood pressure behaves during physical activity in individuals with coronary artery disease (CAD) whose hypertension is managed with first-line antihypertensive medications. 2) To determine whether there were any variations in the front-line medication groups for the treatment of hypertension with respect to the ability of the medications to regulate blood pressure during physical exercise in patients with CAD. Methods: We retrospectively identified 49 CAD patients with hypertension (30 Males & 19 Females) from 68 stress tests.The patient was receiving pharmaceutical monotherapy, with an age of 52±10 years and a normal range rest arterial pressure (≤ 140/90 mmHg). Thirteen were on angiotensin converting enzyme inhibitors, ten on diuretics, twelve on calcium antagonists, and fourteen on beta blockers. Any of the following criteria, when present, led to the diagnosis of abnormal exercise behavior of blood pressure: peak systolic pressure exceeding 220 mmHg, systolic pressure rising by at least 10 mmHg/MET, or diastolic pressure increasing by at least 15 mmHg. Results: In 50% of CAD patients, beta blockers were the best treatment for physiologic response of arterial blood pressure (p<0.05), followed by calcium antagonists (36%), diuretics (31%), and angiotensin converting enzyme inhibitors (20%), which were the worst treatment for physiologic response (p<0.05).In conclusion, beta-blockers were the most effective medication in regulating blood pressure during exercise, whereas angiotensin converting enzyme inhibitors were the least effective. Calcium antagonists, diuretics, and beta-blockers were the least effective.
Keywords: stress test, arterial hypertension, Front-line anti hypertensive drugs, CAD.
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Research & Reviews: A Journal of Pharmacology
| Volume | |
| Received | June 24, 2024 |
| Accepted | July 22, 2024 |
| Published | August 5, 2024 |