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Jagrati shakya,
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Ajit Pal Singh,
- Student Department of Medical Lab Technology, SSAHS, Sharda University, Gr. Noida Uttar Pradesh India
- Assistant Professor Department of Medical Lab Technology, SSAHS, Sharda University, Gr. Noida Uttar Pradesh india
Abstract
Platelets are disc-shaped, anucleate cells that are approximately 2-3 μm in diameter. Their primary function is to control hemostasis, or blood clotting, but they also play important roles in angiogenesis (the formation of new blood vessels) and innate immunity (the body’s first line of defence against infection). With a diameter of just 2-3 microns, platelets are tiny, disc-shaped cells that lack a nucleus. While their main responsibility is to ensure proper blood clotting, they also contribute to wound healing and immune function. Platelets, disc-like cells measuring around 2-3 μm in diameter and lacking a nucleus, are essential for blood clotting (hemostasis). However, their roles extend beyond this, as they also support the formation of new blood vessels (angiogenesis) and the body’s innate immune response. While adult humans have about one trillion platelets constantly circulating, their regeneration mechanism remains largely unknown. Platelets originate from nucleated cells known as megakaryocytes, primarily located in the bone marrow. These cells range in size from 30 to 100 μm. During development, megakaryocytes extend proplatelet elongations into sinusoidal blood vessels, releasing platelets. These platelets develop distinct structural features, including a well-defined plasma membrane, an open canalicular system (OCS), a dense tubular system (DTS), and various organelles like peroxisomes, lysosomes, mitochondria, and dense granules. Understanding the increasingly varied and numerous biological roles of circulating platelets requires an understanding of the complex and multiple process of proplatelet elongation and platelet formation, which defines the morphology and ultrastructure of circulating platelets. Physiological hemostasis involves the quick formation of a platelet plug to stop bleeding following arterial injury. High platelet residual reactivity promotes thromboembolic problems in individuals on antiplatelet medication, whereas qualitative and/or quantitative platelet abnormalities promote bleeding. The molecular mechanisms behind the different phases of platelet activation—adhesion, shape change, release reaction, and aggregation—have been well-defined, although their complete translation into laboratory experiments has not yet been accomplished. Laboratory tests of platelet function, such as bleeding time, Lumi aggregometry, light transmission platelet aggregation, impedance aggregometry on whole blood, and platelet activation assessed by flow cytometry, have historically been used to diagnose hemostatic disorders and treat patients with platelet and hemostatic defects.
Keywords: Cells, Bleeding, membrane, morphology, adhesion.
[This article belongs to Research & Reviews: Journal of Oncology and Hematology(rrjooh)]
References
- Singh AP, Saxena R, Saxena S. A study on the working of blood bank. Journal of Medicine and Health Research. 2022 Jan 10;7(1):1-5.
- Singh AP. Importance of papanicolaou staining in gynecologic cytology. EPRA International Journal of Multidisciplinary Research (IJMR). 2022 Sep 21;8(9):216-9.
- Litjens G, Sánchez CI, Timofeeva N, Hermsen M, Nagtegaal I, Kovacs I, Hulsbergen-Van De Kaa C, Bult P, Van Ginneken B, Van Der Laak J. Deep learning as a tool for increased accuracy and efficiency of histopathological diagnosis. Scientific reports. 2016 May 23;6(1):26286.
- Ismail SM, Colclough AB, Dinnen JS, Eakins D, Evans DM, Gradwell E, O’Sullivan JP, Summerell JM, Newcombe RG. Observer variation in histopathological diagnosis and grading of cervical intraepithelial neoplasia. British Medical Journal. 1989 Mar 18;298(6675):707-10.
- Van Den Bent MJ. Interobserver variation of the histopathological diagnosis in clinical trials on glioma: a clinician’s perspective. Acta neuropathologica. 2010 Sep;120(3):297-304.
- Singh AP, Saxena R, Saxena S. Cytopathology: An Important Aspect of Medical Diagnosis. Research & Reviews: Journal of Oncology and Hematology. 2023; 12 (3): 13–18p. Cytopathology: An Important Aspect of Medical Diagnosis Singh et al. STM Journals. 2023:2.
- Singh AP, Mouton RJ, Sharma MK, Ihotu-Owoicho AI. When will this pandemic end? A review. Journal of Basic and Applied Research International. 2021 Dec 29;29(27):10.
- Singh AP, Batra J, Saxena R, Saxena S, Kumar C. Alarming rise in professional Blood donors and its repercussions. Cardiometry. 2022 Dec 1(25):1394-6.
- Batra J, Singh AP, Saxena R, Saxena S, Goyal K. Blood components and its usage: A clinical insight from diagnostic lens. Journal of Pharmaceutical Negative Results. 2022 Oct 12:1747-50.
- Obiajulu CV, Ochanya OE, Singh AP. Adverse reaction after blood donation in blood bank. International Journal of Pure Medical Research. 2022 Oct 1;7(10).
- Singh AP, Batra J, Khan SS, Saxena R, Saxena S. Diagnosis and treatment of Wilson disease: An update. Cardiometry. 2022 Dec 1(25):1397-400.
- Singh AP, Saxena R, Saxena S, Batra J. An update on emergency contraceptives. IJFANS. 2012;11(2):65-70p.
- Singh AP, Heldaus J, Msaki AP. Hemodialysis Complications: A Clinical Insight. IJARESM. 2023;11(3):640-7.
- Singh AP, Saxena R, Saxena S. An elaborate study on bio-medical waste and its successful administration. International journal of Recent Scientific Research vil. 2022 Jun; 13:2121-6.
- Ajit P, Rahul S, Suyash S. Cytopathology: An important aspect of medical diagnosis. Research & Reviews: Journal of Oncology and Hematology. 2024 Jan 24;12(03):13-8.
- Singh AP, Saxena RA, Saxena SU. Hemoglobin estimation by using copper sulphate method. Asian Journal of Current Research. 2022 Jul 13;7(1):13-5.
- Singh AP, Saxena RA, Saxena SU. Protocols for blood collection in a blood bank. Journal of Medicine and Health Research. 2022 Sep 1;7(2):16-21.
- Harrison P. Platelet function analysis. Blood reviews. 2005 Mar 1;19(2):111-23.
- Singh AP, Batra J, Saxena S, Saxena R. A curse of Lassa fever: An update. Journal of Survey in Fisheries Sciences. 2023 Apr 27:1143-50.
- Thon JN, Italiano JE. Platelet formation. InSeminars in hematology 2010 Jul 1 (Vol. 47, No. 3, pp. 220-226). WB Saunders
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Research & Reviews: Journal of Oncology and Hematology
Volume | 13 |
Issue | 02 |
Received | February 26, 2024 |
Accepted | March 4, 2024 |
Published | August 22, 2024 |