Hyon Chol Jo,
Hak Song Jo,
Kum Hyok So,
- Researcher Department of Pathology, Pyongyang University of Medical Sciences Pyongyang Democratic People’s Republic of Korea
Abstract
Acute Rotavirus gastroenteritis in children, called “False Cholera”, is one of the children’s diarrheal diseases. Among symptomatic children with acute Rotavirus gastroenteritis, the chief clinical manifestations include diarrhoea, vomiting, fever and dehydration. We did research with such aims as follows to differentiate Acute Rotavirus Gastroenteritis in Children, with significant morbidity, from others in paediatric gastroenterology, and to introduce its etiological treatment. We selected 87 subjects who died from children’s diarrheal diseases and collected in several Province Paediatric Hospitals for a good decade. We did qualitative analysis by collecting faecal specimen from the patients died from gastroenteritis and by reacting it with the substrate for the Rotavirus Latex Agglutination Assay to divide patients into two groups: the patients positive for Rotavirus and the negative. We did some types of statistical analyses of the differences between diarrhoea and fever, properties of feces, clinical manifestation and morphology of intestinal mucosa in Rotavirus positive group and the negative. sections using general method with H&E, evaluated the necrotic defluxion of intestinal epithelium under ×100 light microscope (a score of 1; mild, 2; moderate, 3; severe) and observed the changes of villi and counted the infiltrated inflammatory cells in mucosa under ×400 light microscope morphologically. We conducted t-test on diarrhoea and fever and morphology of intestinal mucosa and performed χ2-test on properties of feces and clinical manifestation. Percentage changes according to clinical pathological findings of Acute Rotavirus Gastroenteritis in Children were clearly differ
Keywords: Acute rotavirus gastroenteritis, false cholera, children’s diarrheal diseases, clinical manifestations, paediatric gastroenterology, rotavirus latex agglutination assay.
[This article belongs to Research & Reviews : A Journal of Medical Science and Technology(rrjomst)]
References
- Vasundhara Razdan Tiku, Baoming Jiang, Praveen Kumar, et al. First study conducted in Northen India that identifies group C rotavirus as the etiological agent of severe diarrhea in children in Delhi. Virology Journal. 2017; 14: 100: 1-11p
- Aksara Thongprachum, Sayaka Takanashi, Angelafc Kalesaran, et al. Four-Year Study of Viruses That Cause Diarrhea in Japanese Pediatric Outpatients. Journal of Medical Virology. 2015; 87: 1141-8p
- Ann Mathew, Rajan Srinivasan, Srinivasan Venugopal, et al. Dirrect Medical Costs in Children with Rotavirus and Non-rotavirus Diarrhea Admitted to a Pediatric Intensive Care Unit and High Dependency Unit in Delhi. Indian Pediatrics. 2016; 53: 639-41p
- Liying Liu, Yuan Qian, You Zhang, et al. Epidemiological aspects of rotavirus and adenovirus in hospitalized children with diarrhea: A 5-year survey in Beijing. BMC Infectious Disease. 2016; 16: 508: 1-7p
- Jian Shen, Bi-Meng Zhang, Sheng-Guo Zhu, et al. No Direct correlation between rotavirus diarrhea and breast feeding: A meta-analysis. Pediatrics and Neonatology. 2018; 59: 129-35p
- P. Girish Kumar, Sidhartha Giri, Mamta Chawlasarkar, et al. Epidemiology of rotavirus diarrhea among children less than 5 years hospitalized with acute gastroenteritis prior to rotavirus vaccine introduction in India. Vaccine. 2020; 38: 8154-60p
- Gagandeep Kang, Soro Myanarayanan V. Thuppal, Rajan Srinirasan, et al. Racecado tril in the Management of Rotavirus and Non-rotavirus Diarrhea in Under-five Children: Two Randomized, Double-blind, Placebo-controlled Trials. Indian Pediatrics. 2016; 53: 555-60p
- Neeraj Teotia, Amit Upadhyay, Sunny Agarwal, et al. Rotavirus Diarrhea in Children Presenting to an Urban Hospital in Western Uttar Pradesh, India. Indian Pediatrics. 2016; 53: 627-9p
- Ashok Kumar, Sriparna Basu, Vipin Vashishtha, et al. Burden of Rotavirus Diarrhea in Under-Five Indian Children. Indian Pediatrics. 2016; 53: 607-17p
- Ove Lundgren, Lennart Svensson. Pathogenesis of Rotavirus Diarrhea. Microbes and Infection. 2001; 3: 1145-56p
- Na Jing, Lei Shi, Jiaping Lin, et al. Comparison of two different combined test strips with fluorescent microspheres or colored microspheres as tracers for rotavirus and adenovirus detection. Virology Journal. 2018; 15: 44: 1-5p
- Julia Stowc, Nick Andrews, Shamez Ladhani, et al. The risk of intussusception following monovalent rotavirus vaccination in England: A self-controlled case-series evaluation. Vaccine. 2016; 34: 3684-9p
- Bennett, N. Bar-Zeev, K. C. Jere, et al. Determination of a Viral Load Threshold to Distinguish Symptomatic Versus, Asymptomatic Rotavirus Infection in a High Disease Burden African Population. Journal of Clinical Microbiology. 2015; 53(6): 1951-4p
Research & Reviews : A Journal of Medical Science and Technology
Volume | 13 |
Issue | 02 |
Received | January 30, 2024 |
Accepted | July 5, 2024 |
Published | August 13, 2024 |