Computer-Aided Drug Design on Tuberculosis

Year : 2024 | Volume :14 | Issue : 02 | Page : 22-31
By

Mohd Wasiullah,

Piyush Yadav,

Harsh Sahu,

Satish kumar Yadav,

Vinay Kumar Deepak,

  1. Principal Department of Pharmacy, Prasad Institute of Technology, Jaunpur Uttar Pradesh India
  2. Academic Head Department of Pharmacy, Prasad Institute of Technology, Jaunpur Uttar Pradesh India
  3. Research Scholar Department of Pharmacy, Prasad Institute of Technology, Jaunpur Uttar Pradesh India
  4. Associate professor Department of Pharmacy, Prasad Institute of Technology, Jaunpur Uttar Pradesh India
  5. Associate Professor Department of Pharmacy, Prasad Institute of Technology, Jaunpur Uttar Pradesh India

Abstract

Currently, India’s Directly Observed Treatment Short Course (DOTS) program is the world’s largest and fastest-growing initiative for treating medical patients, second only in terms of population coverage. The main obstacles to TB control in India are inadequate primary healthcare in rural regions of many states, unregulated private treatments resulting in extensive misuse of first- and second-line TB medications, the spread of HIV, a lack of political commitment, and, most importantly, corrupt administration. Tuberculosis (TB) is an airborne disease caused by bacteria from the Mycobacterium tuberculosis complex. tuberculosis is predominantly a lung infection, but it may infect nearly any area of the body. A M. tuberculosis infection can progress from a latent condition, where the bacteria are contained inside granulomas, to a contagious stage, where the patient exhibits symptoms such as fever, chills, coughing, and weight loss. Contagious TB is limited to active pulmonary cases. Drug-resistant tuberculosis (TB) poses a significant challenge in numerous contexts, and TB continues to be a major cause of illness and death in many low- and middle-income countries.

Keywords: Directly Observed Treatment Short Course (DOTS), tuberculosis (TB), drug-resistant TB, first- and second-line TB medications, low- and middle-income nations, active pulmonary TB

[This article belongs to Research & Reviews : A Journal of Immunology(rrjoi)]

How to cite this article: Mohd Wasiullah, Piyush Yadav, Harsh Sahu, Satish kumar Yadav, Vinay Kumar Deepak. Computer-Aided Drug Design on Tuberculosis. Research & Reviews : A Journal of Immunology. 2024; 14(02):22-31.
How to cite this URL: Mohd Wasiullah, Piyush Yadav, Harsh Sahu, Satish kumar Yadav, Vinay Kumar Deepak. Computer-Aided Drug Design on Tuberculosis. Research & Reviews : A Journal of Immunology. 2024; 14(02):22-31. Available from: https://journals.stmjournals.com/rrjoi/article=2024/view=167421



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Regular Issue Subscription Review Article
Volume 14
Issue 02
Received May 29, 2024
Accepted July 19, 2024
Published August 16, 2024

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