A Review on Phytochemistry and Pharmacological Properties of Curcuma amada (Zingiberaceae)

Year : 2024 | Volume : | : | Page : –
By

Nikita Bindal,

Sujata Mohanty,

  1. Research Scholar Department of Biotechnology, Jaypee Institute of Information Technology, Noida Uttar Pradesh India
  2. Professor Department of Biotechnology, Jaypee Institute of Information Technology, Noida Uttar Pradesh India

Abstract

Plant has been employed in traditional medicine since ancient times. Curcuma amada Roxb. (Mango ginger), is a member of Zingiberaceae family and the Curcuma genus. It is a distinctive spice that shares a similar appearance with ginger but provides a raw mango taste. It is considered as a valuable plant in traditional medicine which plays a crucial function in both the food and pharmaceutical industries. Ayurveda and Unani medicinal traditions highly value mango ginger for its properties as an appetizer, antipyretic, diuretic, aphrodisiac, emollient, alexteric, expectorant, and laxative. It is also used to treat biliousness, itching, skin problems, bronchitis, asthma, hiccough, and inflammation resulting from accidents. Mango ginger exhibits a wide range of pharmacological activities, including antioxidant, anthelminthic, antibacterial, antifungal, anticancer, anti-inflammatory, platelet aggregation inhibitory, antidiabetic, brine-shrimp lethal, biopesticide, enterokinase inhibitory, CNS depressant and analgesic activities. The plant contains significant quantities of starch, minerals, vitamins, phenolic acids, volatile oils, curcuminoids, and phytoconstituents such as amadaldehyde, labdane diterpene dialdehyde, difurocumenonol, zederone and amadannulen. C. amada also have a vital function in diverse industrial applications, providing sustainable solutions in multiple sectors. They provide essential raw materials for the food industry, such as edible oils and natural flavorings, and are integral to pharmaceuticals for producing medicines and herbal remedies. Its components, such as essential oils and extracts can be used in cosmetics to improve the effectiveness of skincare and personal care products. This review aimed to focus on the plant’s morphological characteristics, background, chemical properties, pharmacological properties and industrial applications.

Keywords: Curcuma amada, Zingiberaceae family, pharmacological activities, phytoconstituents, industrial applications

How to cite this article: Nikita Bindal, Sujata Mohanty. A Review on Phytochemistry and Pharmacological Properties of Curcuma amada (Zingiberaceae). Research & Reviews : Journal of Herbal Science. 2024; ():-.
How to cite this URL: Nikita Bindal, Sujata Mohanty. A Review on Phytochemistry and Pharmacological Properties of Curcuma amada (Zingiberaceae). Research & Reviews : Journal of Herbal Science. 2024; ():-. Available from: https://journals.stmjournals.com/rrjohs/article=2024/view=170261

References

  1. Chopra B, Dhingra AK. Natural products: A lead for drug discovery and development. Phytotherapy Research. 2021;35(9):4660-702.
  2. Annapurna AS, Abhirami D, Umesh TG. Comparative study of phytochemicals and bioactivities of the leaf extracts of Curcuma amada and Curcuma karnatakensis. South African Journal of Botany. 2021; 142:441-50.
  3. Amanat M, Gautam S, Chalotra R, Lal K, Gupta T, Agrawal R, Mojwar S, Singh R. Zingiber roseum Roscoe (Zingiberaceae): Current and future perspective. Pharmacological Research-Modern Chinese Medicine. 2023; 7:100258.
  4. Debnath S and Vijayan D. Diversity, phytogeographical distribution, endemism and conservation status of Zingiberaceae in India. Plant Sci. Today. 2024;11(2).
  5. Chakraborty A, Santra I, Haque SM, Ghosh B. In vitro conservation of commercial and threatened members of Zingiberaceae: an Indian scenario. Biodiversity and Conservation. 2023;32(7):2155-95.
  6. Policegoudra RS, Vairale MG, Chattopadhyay P, Shivaswamy R, Aradhya SM, Raju PS. Bioactive constituents of Curcuma amada (mango ginger) rhizomes and their antifungal activity against human skin pathogens. Journal of Herbal Medicine. 2020; 21:100331.
  7. Yuandani, Jantan I, Rohani AS, Sumantri IB. Immunomodulatory effects and mechanisms of curcuma species and their bioactive compounds: A review. Frontiers in pharmacology. 2021; 12:643119
  8. Behera S, Monalisa K, Meher RK, Mohapatra S, Madkami SK, Das PK, Naik PK, Naik SK. Phytochemical fidelity and therapeutic activity of micropropagated Curcuma amada: A valuable medicinal herb. Industrial Crops and Products. 2022; 176:114401.
  9. Sutar J, Monalisa K, Pati K, Chauhan VB, Behera S. Qualitative and quantitative phytochemical analysis and antioxidant activity of Curcuma amada Roxb: an important medicinal plant. Plant Arch. 2020;20(2):193-6.
  10. Sahoo S, Jyotirmayee B, Nayak S, Samal HB, Mahalik G. Review on Phytopharmacological Activity of Curcuma amada (Mango ginger). Defence Life Science Journal, 2023; 8 (4): 351-362, DOI: 10.14429/dlsj.8.18793
  11. Policegoudra RS, Aradhya SM, Singh L. Mango ginger (Curcuma amada)–A promising spice for phytochemicals and biological activities. Journal of biosciences. 2011; 36:739-48.
  12. Tamta A, Prakash O, Punetha H, Pant AK. Chemical composition and in vitro antioxidant potential of essential oil and rhizome extracts of Curcuma amada Cogent Chemistry. 2016; 2(1):1168067.https://doi.org/10.1080/23312009.2016.1168067
  13. Chen Y, Shukurova MK, Asikin Y, Kusano M, Watanabe KN. Characterization of Volatile Organic Compounds in Mango Ginger (Curcuma amada) from Myanmar. Metabolites. 2021; 11(1):21. https://doi.org/10.3390/metabo11010021
  14. Al-Qudah TS, Malloh SA, Nawaz A, Ayub MA, Nisar S, Jilani MI, Al-Qudah TS. Mango ginger (Curcuma amada): A phytochemical mini review. IJCBS. 2017; 11:51-7.
  15. Ayodele VO, Olowe OM, Afolabi CG, Kehinde IA. Identification, assessment of diseases and agronomic parameters of Curcuma amada Roxb (Mango ginger). Current Plant Biology. 2018; 15:51-7.
  16. Yadav M, Kaliyaperumal S. Antimicrobial activity of rhizome extracts of Curcuma caesia, Curcuma amada and Curcuma angustifolia. Journal of Advanced Scientific Research. 2021; 12:296-8.
  17. Mahadevi R, Kavitha R. Phytochemical and pharmacological properties of Curcuma amada: A Review. Int. J. Res. Pharm. Sci. 2020;11(3):3546-55.
  18. Gupta The wealth of India. Council of Scientific and Industrial Research, Pusa, New Delhi; 2001. P. 259–260.
  19. Rajkumari S and Sanatombi, K. Nutritional value, phytochemical composition, and biological activities of edible Curcuma species: A review. Int J Food Prop 2017; 20: S2668-S2687. https://doi.org/10.1080/10942912.2017.1387556
  20. Nag A, Banerjee R, Goswami P, Bandyopadhyay M, Mukherjee A. Antioxidant and antigenotoxic properties of Alpinia galanga, Curcuma amada, and Curcuma caesia. Asian Pac J Trop Biomed 2021; 11:363. https://doi.org/10.4103/2221-1691.319571
  21. Rao NLS, Kilari EK, Kola PK. Protective effect of Curcuma amada acetone extract against high-fat and high-sugar diet-induced obesity and memory impairment. Nutr Neurosci 2021; 24:212-25. https://doi.org/10.1080/1028415X.2019.1616436
  22. Padalia, R. C., Verma, R. S., Sundaresan, V., Chauhan, A., Chanotiya, C. S., & Yadav, A. Volatile terpenoid compositions of leaf and rhizome of Curcuma amada from Northern India. Journal of Essential Oil Research, 2013; 25(1):17–22. https://doi.org/10.1080/10412905.2012.747271
  23. Mustafa A, Ali M, Khan NZ. Volatile Oil Constituents of the Fresh Rhizomes of Curcuma amada Journal of Essential Oil Research. 2005; 17(5):490-1.
  1. Padmapriya K, Dutta A, Chaudhuri S, Dutta D, Microwave assisted extraction of mangiferin from Curcuma amada. 3 Biotech. 2011: 1-4.
  2. Policegoudra RS, Divakar S and Aradhya SM. Identification of Difurocumenonol, a new antimicrobial compound isolated from mango ginger (Curcuma amada) rhizome. J. Appl.Microbiol. 2007a; 102:1594–1602.
  3. Policegoudra RS, Abiraj K, Channe Gowda D and Aradhya SM. Isolation and characterization of antioxidant and antibacterial compound from mango ginger (Curcuma amada) rhizome. J. Chromatogr. B. 2007b; 852: 40–48.
  4. Policegoudra RS, Rehna K, Rao LJ and Aradhya SM. Antimicrobial, antioxidant, cytotoxicity and platelet aggregation inhibitory activity of a novel molecule isolated and characterized from mango ginger (Curcuma amada) rhizome. J. Biosci. 2010; 35:23140.
  5. Yu J, Xie J, Sun M, Xiong S, Xu C, Zhang Z, Li M, Li C, Lin L. Plant-Derived Caffeic Acid and Its Derivatives: An Overview of Their NMR Data and Biosynthetic Pathways. Molecules. 2024;29(7):1625.
  6. Pyrzynska K. Ferulic Acid—A Brief Review of Its Extraction, Bioavailability and Biological Activity. Separations. 2024;11(7):204.
  7. Deng H, Xu Q, Guo HY, Huang X, Chen F, Jin L, Quan ZS, Shen QK. Application of cinnamic acid in the structural modification of natural products: A review. Phytochemistry. 2023; 206:113532.
  8. Smirnova E, Moniruzzaman M, Chin S, Sureshbabu A, Karthikeyan A, Do K, Min T. A review of the role of curcumin in metal induced toxicity. Antioxidants. 2023; 12(2):243.
  9. Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, Limtrakul P, Badmaev V, Aggarwal BB. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis. 2007; 28(8):1765-73.
  10. Surendran S, Qassadi F, Surendran G, Lilley D, Heinrich M. Myrcene—what are the potential health benefits of this flavouring and aroma agent?. Frontiers in nutrition. 2021; 8:699666.
  11. Lai EY, Chyau CC, Mau JL, Chen CC, Lai YJ, Shih CF and Lin LL. Antimicrobial activity and cytotoxicity of the essential oil of Curcuma zedoaria. Am. J. Chinese Med. 2004; 32:281-290.
  12. Zhu X, Zhang W, Jin L, Zhang G, Yang H, Yu B. Inhibitory activities of curzerenone, curdione, furanodienone, curcumol and germacrone on Ca2+-activated chloride channels. Fitoterapia. 2020; 147:104736.
  13. Wang Y, Li J, Guo J, Wang Q, Zhu S, Gao S and Zang L. Cytotoxic and antitumor effects of curzerene from Curcuma longa. Planta Medica. 2017; 83:23-29.
  14. Sun XY, Zheng YP, Liu ZF, Xu LL and Li S. Studies on the chemical constituents of sesquiterpenoids from Curcuma wenyujin. J. Instrumental. Anal. 2006; 25: 27–30.
  15. Murakami C, Cordeiro I, Scotti M T, Moreno PRH and Young MCM. Chemical composition, antifungal and antioxidant activities of Hedyosmum brasiliense ex Miq. (Chloranthaceae) essential oils. Medicines. 2017; 4:55.
  16. Batiha GES, Wasef L, Teibo JO, Shaheen HM, Zakariya AM, Akinfe OA and Papadakis M. Commiphora myrrh: a phytochemical and pharmacological update. Naunyn-Schmiedeb Arch Pharmacol. 2023; 396:405-420.
  17. Anjaneyulu B, Saini N. A study on camphor derivatives and its applications: a review. Current Organic Chemistry. 2021; 25(12):1404-28.
  18. Ma R, Lu D, Wang J, Xie Q, Guo J. Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol. Biomedicine & Pharmacotherapy. 2023; 164:114668.
  19. Hachlafi NE, Aanniz T, Menyiy NE, Baaboua AE, Omari NE, Balahbib A, Shariati MA, Zengin G, Fikri-Benbrahim K, Bouyahya A. In vitro and in vivo biological investigations of camphene and its mechanism insights: a review. Food Reviews International. 2023; 39(4):1799-826.
  20. Astani A and PJI Schnitzler. Antiviral activity of monoterpenes betapinene and limonene against herpes simplex virus in vitro. 2014; 6(3):149
  21. Guzmán-Gutiérrez, S., et al., Antidepressant activity of Litsea glaucescens essential oil: identification of 𝛽-pinene and linalool as active principles. 2012;143(2): 673–679
  22. Farré-Armengol G, Filella I, Llusià J, Peñuelas J. β-Ocimene, a key floral and foliar volatile involved in multiple interactions between plants and other organisms. Molecules. 2017; 22(7):1148.
  23. Liu Y, Wang Z, Cui Z, Qi Q, Hou J. Progress and perspectives for microbial production of farnesene. Bioresource Technology. 2022; 347:126682.
  24. Manoharan RK, Lee JH, Kim YG, Kim SI, Lee J. Inhibitory effects of the essential oils α-longipinene and linalool on biofilm formation and hyphal growth of Candida albicans. Biofouling. 2017; 33(2):143-55.
  25. Marchese A, Orhan IE, Daglia M, Barbieri R, Di Lorenzo A, Nabavi SF, Gortzi O, Izadi M, Nabavi SM. Antibacterial and antifungal activities of thymol: A brief review of the literature. Food chemistry. 2016; 210:402-14.
  26. Seshadri VD, Oyouni AA, Bawazir WM, Alsagaby SA, Alsharif KF, Albrakati A, Al‐Amer OM. Zingiberene exerts chemopreventive activity against 7, 12‐dimethylbenz (a) anthracene‐induced breast cancer in Sprague‐Dawley rats. Journal of Biochemical and Molecular Toxicology. 2022; 36(10):e23146.
  27. Tyagi AK, Prasad S, Yuan W, Li S, Aggarwal BB. Identification of a novel compound (β-sesquiphellandrene) from turmeric (Curcuma longa) with anticancer potential: comparison with curcumin. Investigational new drugs. 2015; 33:1175-86.
  28. Mei S, Ma H, Chen X. Anticancer and anti-inflammatory properties of mangiferin: A review of its molecular mechanisms. Food and Chemical Toxicology. 2021; 149:111997
  29. Panwar NS, Singh M, Limaye R, Puri P. Antioxidant and Anti-Inflammatory Studies of Leaf of Ricinus Communis and Rhizome of Curcuma Amada for Topical Application. International Journal of Innovative Science and Research Technology. 2023; 8:1.
  30. Jatoi SA, Kikuchi A, Gilani SA, Watanabe KN. Phytochemical, pharmacological and ethnobotanical studies in mango ginger (Curcuma amada; Zingiberaceae). Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2007; 21(6):507-16.
  31. Hossain CF, Al-Amin M, Rahman KM, Sarker A, Alam MM, Chowdhury MH, Khan SN, Sultana GN. Analgesic principle from Curcuma amada. Journal of ethnopharmacology. 2015; 163:273-7.
  32. Munteanu IG, Apetrei C. Analytical methods used in determining antioxidant activity: A review. International journal of molecular sciences. 2021; 22(7):3380.
  33. Shahidi F, Zhong Y. Measurement of antioxidant activity. Journal of functional foods. 2015;18:757-81.
  34. Prema D, Kamaraj M, Achiraman S, Udayakumar R. In vitro antioxidant and cytotoxicity studies of Curcuma amada (Mango ginger). International Journal of Science and Research. 2014; 4(4):1-6.
  35. Rakh MS, Pawar RV, Khedkar AN. Anthelmintic potential of various extracts of the rhizomes of Curcuma amada Asian Pacific Journal of Tropical Disease. 2014; 4:S276-8.
  36. Randeep G, Vandna K, Amandeep S. Phytochemical investigation and evaluation of anthelmintic activity of Curcuma amada and Curcuma caesia-A comparative study. J Ethnopharmacol. 2011; 2:1-4.
  37. Maria JJ, Karuppiah K, Shariff M, Mukherjee A. Antimicrobial activity of Curcuma amada extract on Streptococcus mutans—An in vitro Journal of Oral and Maxillofacial Pathology. 2023; 27(2):302-6.
  38. Kashyap NK, Deepak J, Bhardwaj AK, Hait M, Pal D. In-vitro antibacterial and antifungal activity of Curcuma amada against human pathogens. Trends in Sciences. 2022; 19(22):4839-.
  39. Policegoudra RS, Vairale MG, Chattopadhyay P, Shivaswamy R, Aradhya SM, Raju PS. Bioactive constituents of Curcuma amada (mango ginger) rhizomes and their antifungal activity against human skin pathogens. Journal of Herbal Medicine. 2020; 21:100331.
  40. Khan R, Kaushik M, Hussain Z. Hepatoprotective and antioxidant efficacy of ethanolic extract of Curcuma amada rhizome against paracetamol induced hepatic toxicity in experimental animals. Int. J. Res. Pharm. Sci. 2020.
  41. Varadarajan R, Mathew MC, Souprayan S. Hepatoprotective efficacy of ethanolic extracts of rhizome Curcuma amada in experimental rats. Ann. Plant Sci. 2018; 71:1966-72.
  42. Kaliaperumal K, Bhat BA, Subramanian K, Ramakrishnan T, Chakravarthy E, Al-Keridis LA, Ahmad I, Alabdallah NM, Saeed M, Karunakaran R. In-vivo anti-hyperglycemic effect of herbal extracts Tribulus terrestris (L) and Curcuma amada (R) on streptozotocin-induced diabetic rats and its associated histopathological studies. Heliyon. 2024; 10(1).
  43. Subha G, Kalaiselvi M. Synthesis and characterization of zinc oxide nanoparticles using Curcuma amada and its in vitro anti-diabetic activity. AIJRSTEM. 2019; 26:149-56.
  44. Syiem D, Sh W M, Sharma R. Hypoglycemic and antihyperglycemic activity of Curcuma amada in normal and alloxan-induced diabetic mice. Pharmacologyonline. 2010; 3:364–372.
  45. Mitra D, Sarkar R, Ghosh D. Antidiabetic and antioxidative properties of the hydro-methanolic extract (60: 40) of rhizomes of Curcuma amada (Zingiberaceae) in streptozotocin-induced diabetic male albino rat: a dose-dependent study through biochemical and genomic approaches. Journal of Complementary and Integrative Medicine. 2019;16(4):20170182.
  46. Jambunathan S, Bangarusamy D, Padma PR, Sundaravadivelu S. Cytotoxic activity of the methanolic extract of leaves and rhizomes of Curcuma amada Roxb against breast cancer cell lines. Asian Pacific journal of tropical medicine. 2014; 7: S405-9.
  47. Ramachandran C, Lollett IV, Escalon E, Quirin KW, Melnick SJ. Anticancer potential and mechanism of action of mango ginger (Curcuma amada) supercritical CO2 extract in human glioblastoma cells. Journal of Evidence-Based Complementary & Alternative Medicine. 2015; 20(2):109-19.
  48. Donipati P, Sreeramulu SH, Donipati PJ, Yugandhar NM. Invitro Anticancer Activity of Curcuma Amada Against Human Breast Cancer Cell Line MCF-7. NeuroQuantology. 2022; 20(20):2875.
  49. Joshi A, Chauhan RS. Phytochemical Analysis and Cytotoxicity Studies of Curcuma amada rhizomes in BHK-21 cells. International Journal of Scientific Research in Environmental Sciences. 2013;1(12):365.
  50. Raaman N, Balasubramanian K. Anticancer and antioxidant activity of Curcuma zedoaria and Curcuma amada rhizome extracts. J. Acad. Ind. Res. 2012; 1:91-6.
  51. Mujumdar AM, Naik DG, Dandge CN, Puntambekar HM. Anti-inflammatory activity of Curcuma amada in albino rats. Indian journal of Pharmacology. 2000;32(6):375-7.
  52. Akter J, Islam MZ, Hossain MA et al. Anti-tyrosinase properties of different species of turmeric and isolation of active compounds from Curcuma amada. Med Chem Res. 2021; 30: 1669–1676. https://doi.org/10.1007/s00044-021-02764-z
  53. Policegoudra RS, Aradhya SM, Singh L. Mango ginger (Curcuma amada)–A promising spice for phytochemicals and biological activities. Journal of biosciences. 2011; 36:739-48.
  54. Ahmad PYA and Ahmad SM. Potential of some rhizomes of Zingiberaceae family as grain protectants against storage insect pests. J. Food Sci. Technol. 1991; 28: 375–377
  55. Krishnaraju AV, Rao TVN, Sundararaju D, Vanisree M, Tsay HS and Subbaraju GV. Biological Screening of Medicinal Plants Collected from Eastern Ghats of India Using Artemia salina(Brine Shrimp Test). Int. J. Appl. Sci. Eng. 2006; 4:115–12
  56. Mujumdar AM, Naik DG, Misar AV, Puntambekar HM and Dandge CN. CNS depressant and analgesic activity of a fraction isolated from ethanol extract of Curcuma amadaPharma. Biol. 2004; 42: 542–546.
Ahead of Print Subscription Original Research
Volume
Received August 1, 2024
Accepted August 28, 2024
Published September 3, 2024
Views: 4

Check Our other Platform for Workshops in the field of AI, Biotechnology & Nanotechnology.
Learn more
Check Out Platform for Webinars in the field of AI, Biotech. & Nanotech.
Learn more