Exploring the Botanical and Pharmacological Significance of Aristolochia rotunda Linn (Zarawand Mudahraj): Traditional Uses, Habitat, and Bioactive Potential

Year : 2024 | Volume : | : | Page : –
By

Asgar Nazir,

Shabnum Khursheed Wani,

  1. PG Scholar Department of Moalajat (Medicine), National Institute of Unani Medicine Bengaluru Karnataka India
  2. PG Scholar Department of Moalajat (Medicine), National Institute of Unani Medicine Bengaluru Karnataka India

Abstract

The plant Aristolochia rotunada Linn (Zarawand Mudahraj) is a member of the Aristolochiaceae family. Its rhizomes are the most valuable portion utilised in the pharmaceutical industry, mostly because of their abundance in bioactive compounds. The medicinal plant Aristolochia rotunda Linn exhibits a spectrum of pharmacological activities essential for combating hyper-uricaemia-induced inflammation. Its anti-inflammatory effects are mediated by inhibiting TNF-α, IL-1β, IL-8, and NF-κB p65 protein expression, crucial in synovial tissue. These actions are attributed to compounds like Aristolochic Acid, Aristolactam IIIa, and flavonoids present in the plant. Moreover, Aristolochia rotunda Linn. acts as a xanthine oxidase inhibitor, reducing uric acid synthesis, thereby mitigating gout symptoms. It also demonstrates antioxidative properties through its phenolic components, including flavonoids, which scavenge free radicals and protect against oxidative damage. Beyond these, the plant exhibits antiviral, antiallergic, antiplatelet, and potential antitumor activities attributed to its flavonoid content. Additionally, it offers neuroprotective effects attributed to specific ligans present. The multifaceted pharmacological profile of Aristolochia rotunda Linn. underscores its potential as a therapeutic agent for conditions.Aristolochia rotunada Linn is yet unexplored, though. In order to uncover other biological activities of Aristolochia rotunada Linn and those of other species in the same genus, as well as to identify the chemicals responsible for these activities, further research should be carried out. The majority of the works studied were Kitabul Umda Fil Jarahat, Bustanul Mufridat, Khazanul Advia, Colleget (Kitabbul Kulliyat), Muheet e Azam, and The Complete Book of the Medical Art (Kamil Sana).

Keywords: Aristolochia rotunada Linn, Traditional Medicine

How to cite this article: Asgar Nazir, Shabnum Khursheed Wani. Exploring the Botanical and Pharmacological Significance of Aristolochia rotunda Linn (Zarawand Mudahraj): Traditional Uses, Habitat, and Bioactive Potential. Research & Reviews : Journal of Herbal Science. 2024; ():-.
How to cite this URL: Asgar Nazir, Shabnum Khursheed Wani. Exploring the Botanical and Pharmacological Significance of Aristolochia rotunda Linn (Zarawand Mudahraj): Traditional Uses, Habitat, and Bioactive Potential. Research & Reviews : Journal of Herbal Science. 2024; ():-. Available from: https://journals.stmjournals.com/rrjohs/article=2024/view=158122

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Received July 18, 2024
Accepted July 20, 2024
Published July 25, 2024
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