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Devshree Yashwantbhai Patel, Dr. Javesh Kashinath Patil, Harsha Vasudev Chaudhari, Aniket Rajesing Girase,
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- Research Scholar, Associate Professor, Research Scholar, Research Scholar Department of Pharmaceutical Quality Assurance P.S.G.V.P. Mandal’s College of Pharmacy Shahada, Dist – Nandurbar ,425409, Department of Pharmaceutical Quality Assurance P.S.G.V.P. Mandal’s College of Pharmacy Shahada, Dist – Nandurbar ,425409, Department of Pharmaceutical Quality Assurance P.S.G.V.P. Mandal’s College of Pharmacy Shahada, Dist – Nandurbar ,425409, Department of Pharmaceutical Quality Assurance P.S.G.V.P. Mandal’s College of Pharmacy Shahada, Dist – Nandurbar ,425409 Maharashtra, Maharashtra, Maharashtra, Maharashtra India, India, India, India
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Abstract
nThe field of analytical chemistry encompasses a variety of methods that are crucial in determining the chemical composition of different substances. UV-visible spectroscopy and high-performance liquid chromatography (HPLC) are two widely utilized methods that are the subject of this article. UV-visible spectroscopy uses the Beer-Lambert law to quantify light absorption, which can provide information about the concentration of absorbing species. The method is based on how light and matter interact, with absorption occurring due to molecular electronic transitions. Conversely, high pressure is used in HPLC to separate mixture components according to how well they bind to a stationary phase. Its versatility stems from a variety of separation techniques, such as size exclusion chromatography, ion exchange, partition, and adsorption. Method development and validation are crucial to guaranteeing the dependability of analytical procedures. It is necessary to assess validation variables including specificity, accuracy, precision, linearity, and robustness to make sure a method is appropriate for the task at hand. Various HPLC techniques for the analysis of ramipril, an ACE inhibitor used to treat hypertension and heart failure, have been explored in the literature. These studies investigated different mobile phases and columns, demonstrating the flexibility of HPLC in pharmaceutical analysis. Ramipril works by blocking the renin-angiotensin-aldosterone system (RAAS), which reduces inflammation and vasoconstriction. This abstract provides an extensive review of analytical chemistry techniques, with special emphasis on their importance in pharmaceutical analysis and drug development.
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Keywords: Ramipril; Hypertension; Analytical method development; Method Validation; HPLC
n[if 424 equals=”Regular Issue”][This article belongs to Journal of Modern Chemistry & Chemical Technology(jomcct)]
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1.Skoog D. A, Nieman TA, Holler FJ. Principles of instrumental analysis. 5th ed. London: Stanford University, Saunders College Publications; 1998; 1-4p. 2.Jeffery G.H, Bassett J, Mendham J, And Denney R C., Vogel’s Textbook of Quantitative Chemical Analysis, 5th Ed., Addison Wesley Longman Inc, Singapore, 2001, 4-5p. 3.Erwing G.W., Instrumental Methods of Chemical Analysis, 2nd Ed., Mcgraw Hill Publishing Company Inc, 1960, 1-3p. 4.Skoog D.A., Holler F.J. And Nieman T.A., Principles of Instrumental Analysis, 5th Ed., Thomson Brooks/Cole Asia Pvt. Ltd, Singapore, 2004, 4-7p.
- Verma G. and Dr. Mishra M.; Development and Optimization of UV-Vis Spectroscopy-A Review. World Journal of Pharmaceutical Research 2018;7(11) :1170-1180p
- A Review on Uv Visible Spectroscopy. International Journal of Pharmaceutical Research and Applications Volume 7, Issue 5 Sep-Oct 2022, pp: 1144-1151 DOI: 10.35629/7781-070511441151
- Thammana; review of high performance liquid chromatography (hplc). RRJPA 2016;5(2):22-28
8.Gita Chawla, Krishna Kr. Chaudhary, a review of HPLC technique covering its pharmaceutical, environmental, forensic, clinical and other application.2019; 6(2): 27-39p
- Jacqueline M.R. Belanger J.R. Jocelyn Pare and Michel Sigouin, High Performance Liquid Chromatography (HPLC): Principle and Application. (1997):38-58p
- Rao TN. Validation of analytical methods. Calibration and validation of analytical methods—a sampling of current approaches. 2018 Apr 25:131-41.10.5772/intechopen.72087.
- Thapar S, Chawla A, Gupta GK. A concise review on method development and validation parameters. GSC Biological and Pharmaceutical Sciences. 2022;19(1):066-77.https://doi.org/10.30574/gscbps.2022.19.1.0136
- Patel Kiran, & Patil Javesh. (2023). Development and Validation of UV-Spectroscopy and UHPLC Method for Gemfibrozil in Bulk Drug and Pharmaceutical Dosage Form [Data set]. In International Journal of Pharma Research and Technology (Vol. 2, Number 3). Zenodo. https://doi.org/10.5281/zenodo.10039607
- Chavan SD, Desai DM. Analytical method validation: A brief review. World Journal of Advanced Research and Reviews. 2022;16(2):389-402.https://doi.org/10.30574/wjarr.2022.16.2.1165
- Kotak RK, Pandya CV, Pandya AC. Validation of novel analytical RP-HPLC method for determination of Formoterol Fumarate and Budesonide in inhalation suspension pharmaceutical dosage form. Research Journal of Pharmacy and Technology. 2021;14(8):4383-90.15. Lavanya Chowdary G, Ravisankar P.Int. J. Pharm. Sci. Rev. Res., 61(2), March – April 2020; Article No. 01, Pages: 1-7
- Eserian JK, Lombardo M. Method validation in pharmaceutical analysis: from theory to practical optimization. Innovations in pharmacy. 2015 Jan 1;6(1).https://doi.org/10.24926/iip.v6i1.376
- Patil Javesh K, Patil Kapil A, Pawar Sunil P. Development and validation of RP-HPLC method for simultaneous estimation of amoxicillin and dicloxacillin in bulk drug and capsules. An International Journal Of Pharmaceutical Sciences. 2014;5(2):39-47.
- Yilmaz B. Determination of ramipril in pharmaceutical preparations by high-performance liquid chromatography. International Journal of Pharmaceutical Sciences Review and Research. 2010 Mar;1(1):39-42.
- Rajoriya VA, Soni A, Kashaw VA. Method development and validation of fast dissolving tablet of ramipril by HPLC method. Int J Pharm Pharm Sci. 2016;8:174-8.https://innovareacademics.in/journals/index.php/ijpps/article/view/9619
- Abdallah NA, El-Brashy AM, Ibrahim FA, El-Awady MI. Micellar eco-friendly HPLC method for simultaneous analysis of ternary combination of aspirin, atorvastatin and ramipril: application to content uniformity testing. BMC chemistry. 2023 Mar 15;17(1):19. https://doi.org/10.1186/s13065-023-00929-y
- Rajput PS, Kaur A, Gill NK, Mittal K, Sarma GS. Simultaneous estimation of ramipril and amlodipine in bulk and tablet dosage form by RP-HPLC method. Journal of Applied Pharmaceutical Science. 2012 Jul 30;2(7):160-5.
- Yada, D., Yada, D., Rajeshwari, T., Madhavilatha, M., & Rani, G. T. (2016). A new validated rp-hplc method for the simultaneous estimation of ramipril and olmesartan medoxomil. International Journal of Pharmacy, 6(1), 177–185. https://www.pharmascholars.com/articles/a-new-validated-rphplc-method-for-the-simultaneous-estimation-of-ramipril-and-olmesartan-medoxomil.pdf
- Rao MP, Srikanth M, Umamaheswari K. Simultaneous estimation of ramipril and olmesartan medoxomil by RP-HPLC method. Int J Pharm Chem Anal. 2017;4:106-1.DOI: 10.18231/2394-2797.2017.0024
- Sharma R, Khanna S, Mishra GP. Development and Validation of RP‐HPLC Method for Simultaneous Estimation of Ramipril, Aspirin and Atorvastatin in Pharmaceutical Preparations. Journal of Chemistry. 2012;9(4):2177-84. https://doi.org/10.1155/2012/89169510.
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Journal of Modern Chemistry & Chemical Technology
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Volume | 15 | |
[if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] | 02 | |
Received | May 24, 2024 | |
Accepted | August 4, 2024 | |
Published | August 14, 2024 |
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