Design and Development of Novel Floating Drug Delivery Systems

[{“box”:0,”content”:”[if 992 equals=”Open Access”]n

n

n

n

Open Access

nn

n

n[/if 992]n

n

Year : August 1, 2024 at 5:20 pm | [if 1553 equals=””] Volume :01 [else] Volume :01[/if 1553] | [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] : 02 | Page : 36-57

n

n

n

n

n

n

By

n

[foreach 286]n

n

n

Urmila C Patel, AmitKumar R. Dhankani, Sunil P. Pawar,

n

    n t

  • n

n

n[/foreach]

n

n[if 2099 not_equal=”Yes”]n

    [foreach 286] [if 1175 not_equal=””]n t

  1. Student, Department of Pharmaceutics,, Assistant Professor, Department of Pharmaceutics,, Principal, P.S.G.V.P.Mandal’s College of Pharmacy, Shahada, Nandurbar,, P.S.G.V.P.Mandal’s College of Pharmacy, Shahada, Nandurbar,, P.S.G.V.P.Mandal’s College of Pharmacy, Shahada, Nandurbar, Maharashtra, Maharashtra, Maharashtra India, India, India

    2. n[/if 1175][/foreach]

n[/if 2099][if 2099 equals=”Yes”][/if 2099]n

n

Abstract

nRecent advances in science and technology have greatly aided in the creation of novel drug delivery methods, especially in addressing physiological issues including irregular stomach emptying times and brief stomach residence periods. Long-term stomach absorption is the goal of gastro-retentive dosage forms (GRDF). Floating drug delivery systems, expanding or swelling systems, polymer-based bioadhesive systems, high-density systems, and other ways that postpone stomach emptying are just a few of the techniques that have been developed to do this. With an emphasis on the main floating mechanism utilized to accomplish stomach retention, this review attempts to gather contemporary literature. There are many advantages to sustained oral release of gastrointestinal dose forms, particularly for medications that act locally in the stomach and are absorbed in the upper regions of the gastrointestinal system. The review includes the physiology of the stomach, variables that affect the excipient’s ability to retain food after it has been consumed, and methods for creating both multi-unit and single-unit hydrodynamically balanced systems. It goes into great length about these systems’ classification, formulation, and evaluation in addition to discussing a few applications.

n

n

n

Keywords: Floating drug delivery systems, single unit, multiple units, evaluation in-vitro and in vivo, gastric residence time, Classification.

n[if 424 equals=”Regular Issue”][This article belongs to International Journal of Pathogens(ijpg)]

n

[/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue under section in International Journal of Pathogens(ijpg)][/if 424][if 424 equals=”Conference”]This article belongs to Conference [/if 424]

n

n

n

How to cite this article: Urmila C Patel, AmitKumar R. Dhankani, Sunil P. Pawar. Design and Development of Novel Floating Drug Delivery Systems. International Journal of Pathogens. August 1, 2024; 01(02):36-57.

n

How to cite this URL: Urmila C Patel, AmitKumar R. Dhankani, Sunil P. Pawar. Design and Development of Novel Floating Drug Delivery Systems. International Journal of Pathogens. August 1, 2024; 01(02):36-57. Available from: https://journals.stmjournals.com/ijpg/article=August 1, 2024/view=0

nn[if 992 equals=”Open Access”] Full Text PDF Download[/if 992] n

n[if 992 not_equal=’Open Access’]
[/if 992]nn

n

nn[if 379 not_equal=””]n

Browse Figures

n

n

[foreach 379]n

n[/foreach]n

n

n

n[/if 379]n

n

References

n[if 1104 equals=””]n

  1. Gupta P, Gnanarajan PK, Kothiyal P. Floating drug delivery system: a review. International Journal of Pharma Research & Review. 2015 Aug;4(8):37-44.
  2. Shyama SK, Sivakumar R. Floating Drug Delivery System: An Updated Review. Int J Curr Pharm Clinical Res. 2014;4(3):150-53.
  3. Parmar PD, Pande S, Shah SH, Sonara N, Patel GH. Floating drug delivery system: A novel approach to prolong gastric retention. World J Pharmacy Pharm Sci. 2014 Feb 25;3(4):418-44.
  4. Veerareddy PR, Bajjuri S, Sanka K, Jukanti R, Bandari S, Ajmeru RK, Potu AR. Formulation and evaluation of gastroretentive dosage form of ofloxacin. Stamford Journal of Pharmaceutical Sciences. 2011;4(1):9-18.
  5. Nirmal J, Saisivam S, Peddanna C, Muralidharan S, Godwinkumar S, Nagarajan M. Bilayer tablets of atorvastatin calcium and nicotinic acid: formulation and evaluation. Chemical and Pharmaceutical Bulletin. 2008 Oct 1;56(10):1455-8.
  6. Hamza YE, Aburahma MH. Design and in vitro evaluation of novel sustained-release double-layer tablets of lornoxicam: utility of cyclodextrin and xanthan gum combination. Aaps Pharmscitech. 2009 Dec;10:1357-67.
  7. El-Kamel AH, Sokar MS, Al Gamal SS, Naggar VF. Preparation and evaluation of ketoprofen floating oral delivery system. International journal of pharmaceutics. 2001 Jun 4;220(1-2):13-21.
  8. Sarojini S, Manavalan R. An overview on various approaches to gastroretentive dosage forms. Int J Drug Dev Res. 2012 Jan;4(1):1-3.
  9. KR V, Gangadhar M, Sandhya S, Banji D. Critical assessment pertaining to Gastric Floating Drug Delivery Systems.
  10. Gaikwad VD, Yadav VD, Jadhav PD. Formulation and evaluation of bilayer floating matrix tablets for captopril. Int J Cur Pharm Rev Res. 2013;4(2):27-35.
  11. Sumith Reddy, Ganesh Kumar Gudas. Formulation and evaluation of floating tablets of esomeprazole. IJPAR [Internet]. 2017 Dec. 23 [cited 2024 Aug. 1];6(4):754-61. Available from: https://ijpar.com/ijpar/article/view/359
  12. Srivastava A. A Review Article on Floating Drug Delivery System Used in Treatment of the Depression. ; International Journal of Scientific and Research Publications (IJSRP) [2019] 9(4) (ISSN: 2250-3153).
  13. Reddy KS, Swain SK, Chowdary KP, Prasad SV. Optimization of valsartan SR floating tablet formulation by 22 factorial design and multiple regression technique. Int Res J Pharm Med Sci. 2018;1:11-5.
  14. Begum RF, Singh S, Prajapati B, Sumithra M, Patel RJ. Advanced targeted drug delivery of bioactive agents fortified with graft chitosan in management of cancer: a review. Current Medicinal Chemistry. 2024.
  15. Senthil A, Suresh Kumar P, Raju CH, Mohideen S. Formulation and evaluation of gastric oral floating tablet of glipizide. International Journal of Biological and Pharmaceutical Research. 2010;1(2):108-13.
  16. Haritha Sunil, MouryaAdarsh, Praveen Kanna, Sampath.M. Design formulation and evaluation of gastroretentive floating tablets of stavudine. Int. J. of Res. in Pharmacology &Pharmacotherapeutics [Internet]. 2021Apr.14 [cited 2024Aug.1];6(1):93-103. Available from: https://ijrpp.com/ijrpp/article/view/125
  17. Viveksarathi K, Kannan K. Design and in vitro Evaluation of Gastroretentive Floating Drug Delivery System of Rosigilitazone Maleate. Journal of Pharmaceutical Sciences and Research. 2013 Aug 1;5(8):166.
  18. Sohail K, Javaid Z, Hamid I, Sharif A, Akhtar MF, Raza M, Ali S, Shabbir M, Peerzada S, Ahmad S. Formulation and evaluation of ranitidine floating tablets using different polymer combinations. J Toxicol Pharmaceut Sci. 2017;1(1):18-25.
  19. Shahzad Y, Ibrar N, Hussain T, Yousaf AM, Khan IU, Rizvi SA. Relevancy of nizatidine’s release from floating tablets with viscosity of various cellulose ethers. Sci. 2021 Apr 8;3(2):22.
  20. Hafeez A, Maurya A, Singh J, Mittal A, Rana L. An overview on floating microsphere: Gastro Retention Floating drug delivery system (FDDS). The Journal of Phytopharmacology. 2013;2(3):1-2.
  21. Jeganath S, Shafiq KM, Mahesh PG, Kumar SS. Formulation and evaluation of non-effervescent floating tablets of linagliptin using low-density carriers. Drug Invention Today. 2018 Mar 1;10(3).
  22. Patel KS, Rao AN, Patel DR, Patel DM, Patel AB. Formulation and Evaluation of Gastroretentive Floating Tablets of Quetiapine Fumarate. Journal of Drug Delivery and Therapeutics. 2021 Jun 15;11(3-S):65-73.
  23. Kumari SD, Vengatesh S, Elango K, Damayanthi RD, Deattu N, Christina P. Formulation and evaluation of floating tablets of ondansetron hydrochloride. Int J Drug Dev Res. 2012;4(4):265-74.
  24. Jain D, Verma S, Shukla SB, Jain AK, Jain P, Yadav P. Formulation and evaluation of gastroretentive tablets of Furosemide (Evaluation based on drug release kinetics and factorial designs). Journal of Chemical and Pharmaceutical Research. 2010;2(4):935-78.
  25. Bhardwaj V, Harikumar SL. Floating drug delivery system: A review. Pharmacophore. 2013;4(1-2013):26-38.
  26. Pawar VK, Kansal S, Garg G, Awasthi R, Singodia D, Kulkarni GT. Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems. Drug delivery. 2011 Feb 1;18(2):97-110.
  27. Valte YB, Sangale HA, Kathuria HS, Talele SG, Jadhav AG. Formulation and evaluation of gastro retentive extended release formulation of metformin hydrochloride. GSC Advanced Research and Reviews. 2020 Feb 28;2(2):008-17.
  28. Patil M, Vidyasagar G, Patil VB. Formulation, optimization and evaluation of floating tablets clarithromycin. Int J Pharm Pharm Sci. 2015;7(5):320-6.
  29. Airemwen OC, Uhumwangho MU. Gastro-floating drug delivery systems-A review. Tropical Journal of Natural Product Research (TJNPR). 2017 Sep 1;1(3):105-9.
  30. Jagdale SC, Patil S, Kuchekar BS. Application of design of experiment for floating drug delivery of tapentadol hydrochloride. Computational and mathematical methods in medicine. 2013;2013(1):625729.
  31. Javaid MU, ul Ain Q, Tahir U, Shahid S. A summarized review about natural polymers role in floating drug delivery system and in-vivo evaluation studies. International Current Pharmaceutical Journal. 2017 Jun 15;6(4):23-6.
  32. MISTRY RB, SHETH NS. Formulation and evaluation of floating drug delivery system. Int J Pharma and bio sciences. 2011;2(1):571-80.
  33. Chauhan YS, Kataria U, Dashora A. Formulation and evaluation of floating tablet for indomethacin. Journal of Drug Delivery and Therapeutics. 2018 Jul 17;8(4):338-45.
  34. Gaikwad MR, Chemate SZ, Shaikh MS. FORMULATION AND IN-VITRO EVALUATION OF FLOATING TABLETS OF TELMISARTAN.
  35. Shanmuga Priya P. Formulation and Evaluation of Gastroretentive Floating Matrix Tablets of Perindopril Erbumine (Doctoral dissertation, College of Pharmacy, Madurai Medical College, Madurai, Tamil Nadu, India).
  36. Meka VS, Kohila Vani A, Gudy PJ, Sheshala R. Development of gastroretentive floating tablets of diltiazem hydrochloride and its statistical optimization. Farmacia. 2016 Jul 1;64(4):572-80.
  37. Jennissen HP. Ubiquitin and the enigma of intracellular protein degradation. European Journal of Biochemistry. 1995 Jul;231(1):1-30.
  38. Reddy VS. Formulation and evaluation of floating tablets of ciprofloxacin hydrochloride. Asian Journal of Pharmaceutics (AJP). 2018 May 30;12(02).
  39. Bellad K, Nanjwade B, Sarkar A, Srichana T, Shetake R. Development and evaluation of curcumin floating tablets. Pharm Anal Acta. 2020;12:622.
  40. Hooda A. Gastroretentive drug delivery systems: A review of formulation approaches. The pharma innovation. 2012 Oct 1;1(8).
  41. Puthoori H, Murthy TE, Kaushik A. Formulation and evaluation of floating tablets of niacin for sustained release. Asian Journal of Pharmaceutics (AJP). 2012;6(1).
  42. Ichikawa M, Watanabe S, Miyake Y. A new multiple-unit oral floating dosage system. I: Preparation and in vitro evaluation of floating and sustained-release characteristics. Journal of pharmaceutical sciences. 1991 Nov 1;80(11):1062-6.
  43. Gu TH, Chen SX, Zhu JB, Song DJ, Guo JZ, Hou HM. Pharmacokinetics and pharmacodynamics of diltiazem floating tablets. Zhongguo yao li xue bao= Acta Pharmacologica Sinica. 1992 Nov 1;13(6):527-31.
  44. Rouge N, Cole ET, Doelker E, Buri P. Buoyancy and drug release patterns of floating minitablets containing piretanide and atenolol as model drugs. Pharmaceutical development and technology. 1998 Jan 1;3(1):73-84.
  45. Nur AO, Zhang JS. Captopril floating and/or bioadhesive tablets: design and release kinetics. Drug development and industrial pharmacy. 2000 Jan 1;26(9):965-9.
  46. Sarawade A, Ratnaparkhi MP, Chaudhari S. Floating drug delivery system: an overview. International Journal of Research and Development in Pharmacy & Life Sciences. 2014 Sep 15;3(5):1106-15.
  47. Choudhury A, Renthlei L, Dewan M, Ahmed R, Barakoti H, Dey BK. Floating drug delivery system: an outlook. Journal of applied pharmaceutical research. 2019 Sep 30;7(3):01-8.
  48. Garg RG, Gupta GD. Progress in controlled gastroretentive delivery systems. Tropical journal of pharmaceutical research. 2008 Sep 11;7(3):1055-66.
  49. Panda S, Sailada NS, Devi B, Pattnaik S, Maharana L. Design of floating drug delivery systems: An update on polymeric advancements with special reference from natural origin. Int. J. Pharm. Sci. Rev. Res. 2016 Jul;39(1):125-32.
  50. Singh A, Malviya R, K Sharma P. Pulmonary drug delivery system: a novel approach for drug delivery. Current Drug Therapy. 2011 May 1;6(2):137-51.
  51. Yu J, Chien YW. Pulmonary drug delivery: physiologic and mechanistic aspects. Critical Reviews™ in Therapeutic Drug Carrier Systems. 1997;14(4).
  52. Kamalakkannan V, Puratchikody A, Prasanth VV, Masilamani K. Enhancement of drugs bioavailability by floating drug delivery system-A review. International Journal of Drug Delivery. 2011 Oct 1;3(4):558.
  53. Deshpande AA, Shah NH, Rhodes CT, Malick W. Development of a novel controlled-release system for gastric retention. Pharmaceutical research. 1997 Jun;14:815-9.
  54. Patel DM, Patel MJ, Patel AN, Patel CN. Formulation and evaluation of mixed matrix gastro-retentive drug delivery for famotidine. International Journal of Pharmaceutical Investigation. 2011 Oct;1(4):247.
  55. Kaushik AY, Tiwari AK, Gaur A. Role of excipients and polymeric advancements in preparation of floating drug delivery systems. International journal of pharmaceutical investigation. 2015 Jan;5(1):1.
  56. Singh PK. Bilayer and floating-bioadhesive tablets: innovative approach to gastroretension. Journal of Drug Delivery and Therapeutics. 2011 Oct 25;1(1).
  57. Kumar MR, Satyanarayana B, Paladugu ND, Neerukondavamsi SM, Pasha SI, Vemireddy SP, Poloju DE. A comprehensive review on gastro retentive drug delivery system. Acta Chimica Pharmaceutica Indica. 2013;3(2):149-64.
  58. Lopes CM, Bettencourt C, Rossi A, Buttini F, Barata P. Overview on gastroretentive drug delivery systems for improving drug bioavailability. International journal of pharmaceutics. 2016 Aug 20;510(1):144-58.
  59. Tamizharasi S, Rathi V, Rathi JC. Floating Drug Delivery System. Systematic Reviews in Pharmacy. 2011 Jan 1;2(1).
  60. Jiang H, Tian R, Hu W, Jia Y, Yuan P, Wang J, Zhang L. Formulation and evaluation of gastroretentive floating drug delivery system of dipyridamole. Drug development and industrial pharmacy. 2015 Apr 3;41(4):674-80.
  61. Pund SB, Bhagat VC, Deshmukh MT, Kardile DP, Shete RV. A review on floating multi-particulate drug delivery system. Research Journal of Pharmacy and Technology. 2021;14(7):3987-92.
  62. Patil DH, Malpure PS. Formulation and evaluation of gastroretentive floating alginate beads of lafutidine by ionotropic gelation method. World J Pharm Res. 2016 May 5;5:1070-86.
  63. Varshosaz J, Tavakoli N, Roozbahani F. Formulation and in vitro characterization of ciprofloxacin floating and bioadhesive extended-release tablets. Drug delivery. 2006 Jan 1;13(4):277-85.
  64. TAMIZHARASI S, SIVAKUMAR T, CHANDRA RJ. International Journal of Drug Development & Research| July-September 2011| Vol. 3| Issue 3| ISSN 0975-9344| Available online http://www. ijddr. in Covered in Official Product of Elsevier, The Netherlands© 2010 IJDDR. Int. J. Drug Dev. & Res. 2011 Jul;3(3):242-51.
  65. Ramesh Babu, J., Vidyadhara, S., & Basha, A. (2013). Formulation and in vitro evaluation of ofloxacin as floating drug delivery system. Der Pharmacia Lettre, 5(5), 82–92.
  66. Brahmaiah B, Bhagath GP, Gudipati M. Formulation and evaluation of gastroretentive floating drug delivery system of metoprolol tartarate. International Journal of Life Sciences Biotechnology and Pharma Research. 2013 Jan;2(1):183-97.
  67. Pahwa R, Bisht S, Kumar V, Kohli K. Recent advances in gastric floating drug delivery technology: a review. Current Drug Delivery. 2013 Jun 1;10(3):286-98.
  68. Bakhsh EM. Highly Efficient and Recoverable Ag-Cu Bimetallic Supported Catalyst Applied for Dyes and Nitroarenes Reduction 2.
  69. Shakya R, Thapa P, Saha RN. In vitro and in vivo evaluation of gastroretentive floating drug delivery system of ofloxacin. asian journal of pharmaceutical sciences. 2013 Jun 1;8(3):191-8.
  70. Dongare PS, Darekar AB, Gondkar SB, Saudagar RB. Floating drug delivery system: A better approach. International Journal of Pharmacy and Biological Sciences. 2013 Oct;3(4):72-85.
  71. Gupta R, Tripathi P, Bhardwaj P, Mahor A. Recent advances in gastro retentive drug delivery systems and its application on treatment of H. Pylori infections. Journal of Analytical & Pharmaceutical Research. 2018;7(4):404-10.
  72. Kusuma D, Krishnan KS, Sri S, Sree V. Formulation and evaluation of floating microspheres of acebutolol. Int J Pharm Sci Rev Res. 2017;46:31-6.
  73. Philip AK, Philip B. Colon targeted drug delivery systems: a review on primary and novel approaches. Oman medical journal. 2010 Apr;25(2):79.
  74. Patil, J. M., Hirlekar, R. S., Gide, P. S., & Kadam, V. J. (2006). Trends in floating drug delivery systems. Journal of Scientific and Industrial Research, 65(1), 11–21.
  75. P., Patel, N. A., Shah, S., & Shah, N. (2015). Review on : Gastro-Retentive Floating Drug Delivery System for the Treatment of H. Pylori Infection. 5(3), 249–253.
  76. Tripathi J, Thapa P, Maharjan R, Jeong SH. Current state and future perspectives on gastroretentive drug delivery systems. Pharmaceutics. 2019 Apr 20;11(4):193.
  77. Devi P, Rajamanickam V. The recent developments on gastric floating drug delivery systems: An overview. Int J Pharm Tech Research. 2010;2:524-34.
  78. VenKateswarlu K, Chandrasekhar KB. Development and statistical optimization of sustained release gastro retentive floating tablets of cephalexin. Marmara Pharmaceutical Journal. 2016 Jan 1;20(2):172-83.
  79. Priya VS, Roy HK, Jyothi N, Prasanthi NL. Polymers in drug delivery technology, types of polymers and applications. Sch. Acad. J. Pharm. 2016;5:305-8.
  80. Bogdanova Popov B, Karapetkovska-Hristova V, Ahmad MA, Shariati MA. An overview on applications of guar gum in food systems to modify structural properties. Saudi J. Med. Pharm. Sci.. 2017;3(5):373-6.
  81. Meka VS, LIANG VA, WEE PH, Dharmalingham SR, Sheshala R, Gorajana A. Preparation and in vitro characterization of non-effervescent floating drug delivery system of poorly soluble drug, carvedilol phosphate. Acta Pharmaceutica. 2014 Dec 31;64(4):485-94.
  82. Vasave VS. A REVIEW ON: FLOATING DRUG DELIVERY SYSTEM. World Journal of Pharmaceutical Research. 2023;12(2):641-69.
  83. Ganesh K, Archana D, Preeti K. Natural polymers in the development of floating drug delivery systems: A Review. International Journal of Pharmaceutical and Life Sciences. 2013 Oct 1;2(4):165-78.
  84. Gadge G, Sabale V, KHADE A. Current approaches on gastro retentive drug delivery system: an overview. International Journal of Pharmacy Research & Technology (IJPRT). 2019;9(2):16-28.
  85. Saxena A, Gaur K, Singh V, Singh RK, Dashora A. Floating microspheres as drug delivery system. American Journal of Pharmacy and Pharmaceutical Sciences. 2014;1(2):27-36.
  86. Yadav V, Jadhav P, Salunkhe P, Nikam P, Matkar S. Formulation and evaluation of gastroretentive tablets of antiulcer drug. Asian J Pharm Clin Res. 2016;9(6):48-52.
  87. Sarawade A, Ratnaparkhi MP, Chaudhari S. Floating drug delivery system: an overview. International Journal of Research and Development in Pharmacy & Life Sciences. 2014 Sep 15;3(5):1106-15.
  88. Shadab MD, Singh GK, Ahuja A, Khar RK, Baboota S, Sahni JK, Ali J. Mucoadhesive Microspheres as a Controlled Drug Delivery System for Gastroretention. Systematic Reviews in Pharmacy. 2012 Jan 1;3(1).
  89. Gupta P, Gnanarajan PK, Kothiyal P. Floating drug delivery system: a review. International Journal of Pharma Research & Review. 2015 Aug;4(8):37-44.
  90. NASA P, MAHANT S, SHARMA D. International Journal of Pharmacy and Pharmaceutical Sciences. Int J Pharmacy and Pharm Sci.2010 ;2(3):2-7.
  91. Patel SS, Ray S, Thakur RS. Formulation and evaluation of floating drug delivery system containing clarithromycin for Helicobacter pylori. Acta Pol Pharm. 2006 Jan 1;63(1):53-61.
  92. Bajpai SK, Dubey S. Dynamic release of vitamin B2 from floating barium alginate beads for gastric delivery. Journal of macromolecular science, part a: pure and applied chemistry. 2007 Jun 1;44(9):1005-11.
  93. Arza RA, Gonugunta CS, Veerareddy PR. Formulation and evaluation of swellable and floating gastroretentive ciprofloxacin hydrochloride tablets. AAPs PharmsciTech. 2009 Mar;10:220-6.
  94. Tadros MI. Controlled-release effervescent floating matrix tablets of ciprofloxacin hydrochloride: Development, optimization and in vitro–in vivo evaluation in healthy human volunteers. European journal of pharmaceutics and biopharmaceutics. 2010 Feb 1;74(2):332-9.
  95. Vo AQ, Feng X, Morott JT, Pimparade MB, Tiwari RV, Zhang F, Repka MA. A novel floating controlled release drug delivery system prepared by hot-melt extrusion. European Journal of Pharmaceutics and Biopharmaceutics. 2016 Jan 1;98:108-21.
  96. Gadad AP, Patil MB, Naduvinamani SN, Mastiholimath VS, Dandagi PM, Kulkarni AR. Sodium alginate polymeric floating beads for the delivery of cefpodoxime proxetil. Journal of applied polymer science. 2009 Nov 1;114(3):1921-6.
  97. Garg RG, Gupta GD. Progress in controlled gastroretentive delivery systems. Tropical journal of pharmaceutical research. 2008 Sep 11;7(3):1055-66.
  98. Hoffman A, Stepensky D, Lavy E, Eyal S, Klausner E, Friedman M. Pharmacokinetic and pharmacodynamic aspects of gastroretentive dosage forms. International journal of pharmaceutics. 2004 Jun 11;277(1-2):141-53.
  99. Jagdale SC, Agavekar AJ, Pandya SV, Kuchekar BS, Chabukswar AR. Formulation and evaluation of gastroretentive drug delivery system of propranolol hydrochloride. AAPS PharmSciTech. 2009 Sep;10:1071-9.
  100. Adepu S, Ramakrishna S. Controlled drug delivery systems: current status and future directions. Molecules. 2021 Sep 29;26(19):5905.
  101. Jain SK, Agrawal GP, Jain NK. Evaluation of porous carrier-based floating orlistat microspheres for gastric delivery. AAPS pharmscitech. 2006 Dec;7:E54-62.
  102. Mayavanshi AV, Gajjar SS. Floating drug delivery systems to increase gastric retention of drugs: A Review. Research Journal of Pharmacy and Technology. 2008;1(4):345-8.
  103. Rathnanand M, Pannala S. Formulation and in vitro evaluation of floating pulsatile tablets of nizatidine for chronotherapy of ulcers. J Pharm Res. 2011 May;4(5):1388-90.
  104. MIYAZAKI S, YAMAGUCHI H, YOKOUCHI C, TAKADA M, HOU WM. Sustained-release and intragastric-floating granules of indomethacin using chitosan in rabbits. Chemical and pharmaceutical bulletin. 1988 Oct 25;36(10):4033-8.
  105. Kharia AA, Hiremath SN, Singhai AK, Omray LK, Jain SK. Design and optimization of floating drug delivery system of acyclovir. Indian journal of pharmaceutical sciences. 2010 Sep;72(5):599.
  106. Prajapati ST, Patel LD, Patel DM. Studies on formulation and in vitro evaluation of floating matrix tablets of domperidone. Indian journal of pharmaceutical sciences. 2009 Jan;71(1):19.
  107. Li DX, Kim JO, Oh DH, Lee WS, Hong MJ, Kang JY, Choi JS, Woo JS, Yong CS, Choi HG. Development of nifedipine-loaded coated gelatin microcapsule as a long acting oral delivery. Archives of pharmacal research. 2009 Jan;32:127-32.
  108. Porwal A, Dwivedi H, Pathak K. Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy. Brazilian Journal of Pharmaceutical Sciences. 2017;53(03):e00173.
  109. Mukhi U, Mohanty S. Formulation and evaluation of floating tablets of cefuroxime axetil. International Journal of Pharmacy and Pharmaceutical Sciences. 2013;5(4):156-61.

nn[/if 1104][if 1104 not_equal=””]n

    [foreach 1102]n t

  1. [if 1106 equals=””], [/if 1106][if 1106 not_equal=””],[/if 1106]

    2. n[/foreach]

n[/if 1104]

nn

nn[if 1114 equals=”Yes”]n

n[/if 1114]

n

n

[if 424 not_equal=””]Regular Issue[else]Published[/if 424] Subscription Review Article

n

n

n

n

n

International Journal of Pathogens

n

[if 344 not_equal=””]ISSN: [/if 344]

n

n

n

n

n

[if 2146 equals=”Yes”][/if 2146][if 2146 not_equal=”Yes”][/if 2146]n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n[if 1748 not_equal=””]

[else]

[/if 1748]n

n

n

Volume 01
[if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 02
Received May 9, 2024
Accepted July 26, 2024
Published August 1, 2024

n

n

Views: 12

n

n

n

n nfunction myFunction2() {nvar x = document.getElementById(“browsefigure”);nif (x.style.display === “block”) {nx.style.display = “none”;n}nelse { x.style.display = “Block”; }n}ndocument.querySelector(“.prevBtn”).addEventListener(“click”, () => {nchangeSlides(-1);n});ndocument.querySelector(“.nextBtn”).addEventListener(“click”, () => {nchangeSlides(1);n});nvar slideIndex = 1;nshowSlides(slideIndex);nfunction changeSlides(n) {nshowSlides((slideIndex += n));n}nfunction currentSlide(n) {nshowSlides((slideIndex = n));n}nfunction showSlides(n) {nvar i;nvar slides = document.getElementsByClassName(“Slide”);nvar dots = document.getElementsByClassName(“Navdot”);nif (n > slides.length) { slideIndex = 1; }nif (n (item.style.display = “none”));nArray.from(dots).forEach(nitem => (item.className = item.className.replace(” selected”, “”))n);nslides[slideIndex – 1].style.display = “block”;ndots[slideIndex – 1].className += ” selected”;n}n”}]

Check Our other Platform for Workshops in the field of AI, Biotechnology & Nanotechnology.
Learn more
Check Out Platform for Webinars in the field of AI, Biotech. & Nanotech.
Learn more