Review on Formulation and Evaluation of Herbal Gel of Moringa oleifera and Aloe Vera for management of acne

Year : 2026 | Volume : 13 | 01 | Page :
    By

    Prashant.G.Shimpi,

  • Neha.P.Patil,

  • Krutdyna.P.Patil,

  • Mrunal.D.Pendalkar,

  • Sunil.P.Pawar,

  • Gaurav.B.Sonawane,

  1. Student, B. Pharm, Department of Pharmaceutics, P. S. G. V. P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India
  2. Assistant Professor, Department of Pharmaceutical Chemistry, P. S. G. V. P. Mandal’s College of Pharmacy, Shahada, Maharashtra, Maharashtra, India
  3. Assistant Professor, Department of Pharmaceutical Chemistry, P. S. G. V. P. Mandal’s College of Pharmacy, Shahada, Maharashtra, Maharashtra, India
  4. Assistant Professor, Department of Pharmaceutical Chemistry, P. S. G. V. P. Mandal’s College of Pharmacy, Shahada, Maharashtra, Maharashtra, India
  5. Principal, Department of Pharmaceutical Chemistry, P. S. G. V. P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India
  6. Student, B. Pharm, Department of Pharmaceutics, P. S. G. V. P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India

Abstract

Acne vulgaris is a prevalent chronic inflammatory disorder of the pilosebaceous units, characterized by excessive sebum production, follicular hyperkeratinization, bacterial colonization, and inflammation. Conventional therapies often result in side effects and the development of drug resistance, prompting the exploration of natural alternatives. This review highlights the potential of Moringa oleifera and Aloe vera in acne management via topical drug delivery systems (TDDS). Moringa oleifera is rich in bioactive compounds such as niazimicin, quercetin, and isothiocyanates, which exhibit strong antimicrobial, anti-inflammatory, antioxidant, and antidiabetic properties. Aloe vera, containing acemannan, vitamins, and polyphenols, provides moisturizing, wound-healing, and antimicrobial benefits. TDDS allows for site-specific drug delivery, improved patient compliance, and reduced systemic side effects, making it a promising strategy for acne therapy. Combining Moringa oleifera and Aloe vera in topical formulations may enhance efficacy against acne-causing pathogens like Propionibacterium acnes and Staphylococcus aureus. Further preclinical and clinical studies are warranted to establish safety, stability, and long-term therapeutic outcomes. This herbal-based TDDS offers a potential eco-friendly, effective, and patient-friendly alternative for acne treatment.

Keywords: Moringa oleifera, Aloe vera, Acne vulgaris, Topical drug delivery system (TDDS), Herbal formulation

How to cite this article:
Prashant.G.Shimpi, Neha.P.Patil, Krutdyna.P.Patil, Mrunal.D.Pendalkar, Sunil.P.Pawar, Gaurav.B.Sonawane. Review on Formulation and Evaluation of Herbal Gel of Moringa oleifera and Aloe Vera for management of acne. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2026; 13(01):-.
How to cite this URL:
Prashant.G.Shimpi, Neha.P.Patil, Krutdyna.P.Patil, Mrunal.D.Pendalkar, Sunil.P.Pawar, Gaurav.B.Sonawane. Review on Formulation and Evaluation of Herbal Gel of Moringa oleifera and Aloe Vera for management of acne. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2026; 13(01):-. Available from: https://journals.stmjournals.com/rrjodfdp/article=2026/view=236091


References

1.Fatima GX, Vijetha RJ, Raj SR, Shanthi S, Latha S, Shanmuganathan S. Formulation and evaluation of polyherbal anti-acne gel. Advances in Journal of Pharmacy and Life Sciences Research.2015;3(1):5-8.
2.N and P, Drabu S, Gupta RK, Bhatnagar A, Ali R. In vitro and in vivo assessment of polyherbal topical gel formulation for the treatment of acne vulgaris. International Journal of Drug Delivery. 2012;4:434-42.
3.Chu TC. Acne and other facial eruptions. Medicine 1997;25:30–3.
4.Vos, T. Et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 380(9859), 2163–96,https://doi.org/10.1016/s0140-6736(12)61729-2 (2012).
5.T, V., Kilkenny, M. & Marks, R. Descriptive epidemiology of acne vulgaris in the community. Australas J Dermatol. 38(3), 115–23,https://doi.org/10.1111/j.14400960.1997.tb01126.x (1997).
6.Ravisankar P, Koushik OS, Himaja V, Ramesh J, Pragna P. Acne-causes and amazing remedial measures for acne. Indo American Journal of Pharmaceutical Research. 2015, 5(7).
7.Motosko CC, Zakhem GA, Pomeranz MK, Hazen A. Acne: a side-effect of masculinizing hormonal therapy in transgender patients. Br J Dermatol. 2019 Jan;180(1):26-30.
8.Gollnick H, Cunliffe W, Berson D, Dreno B, Finlay A, Leyden JJ, Shalita AR, Thiboutot D., Global Alliance to Improve Outcomes in Acne. Management of acne: a report from a Global Alliance to Improve Outcomes in Acne. J Am Acad Dermatol. 2003 Jul;49(1 Suppl):S1-37.
9.Adebamowo CA, Spiegelman D, Danby FW, Frazier AL, Willett WC, Holmes MD. High school dietary dairy intake and teenage acne. J Am Acad Dermatol. 2005 Feb;52(2):207-14.
10.Thiboutot D. Acne: hormonal concepts and therapy. Clin Dermatol. 2004 SepOct;22(5):41928.

11.Cappel M, Mauger D, Thiboutot D. Correlation between serum levels of insulin-like growth factor 1, dehydroepiandrosterone sulfate, and dihydrotestosterone and acne lesion count in adult women. Arch Dermatol. 2005 Mar;141(3):333-8.
12.Holmes MD, Pollak MN, Willett WC, Hankinson SE. Dietary correlates of plasma insulinlike growth factor I and insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol Biomarkers Prev. 2002 Sep;11(9):852-61.
13.Spencer EH, Ferdowsian HR, Barnard ND. Diet and acne: a review of the evidence. Int J Dermatol. 2009 Apr;48(4):339-47.
14.Yosipovitch G, Tang M, Dawn AG, Chen M, Goh CL, Huak Y, Seng LF. Study of psychological stress, sebum production and acne vulgaris in adolescents. Acta Derm Venereol. 2007;87(2):135-9.
15.Chiu A, Chon SY, Kimball AB. The response of skin disease to stress: changes in the severity of acne vulgaris as affected by examination stress. Arch Dermatol. 2003 Jul;139(7):897-900.
16.H. Gollnick, W. Cunliffe, D. Berson, B. Dreno, A. Finlay, J.J. Leyden, A.R. Shalita,D. Thiboutot, T. Schwarz, Management of acne: a report from a global alliance to improve outcomes in acne, J. Am. Acad. Dermatol. 49 (2003) 1–37.
17.J.K.L. Tan, L.F. Stein Gold, A.F. Alexis, J.C. Harper, Current concepts in acne Pathogenesis: pathways to inflammation, Semin. Cutan. Med. Surg. (2018), https://doi.org/10.12788/J.SDER.2018.024.
18.A.L. Byrd, Y. Belkaid, J.A. Segre, The human skin microbiome, Nat. Rev. Microbiol. 16 (2018) 143–155.
19.V. Jhawat, M. Gulia, B. Maddiboyina, R. Dutt, S. Gupta, Fate and applications of Superporous hydrogel systems: a review, Curr Nanomedicine (2020), https://doi.Org/10.2174/2468187310999200819201555.
20.P. N Chauhan, A. Sharma, H. Rasheed, H. Mathur, P. Sharma, Treatment opportunities and technological progress prospective for acne vulgaris, Curr. Drug Deliv. (2022), https://doi.org/10.2174/1567201819666220623154225.
21.Prausnitz MR, Langer R. Transdermal drug delivery. Nature Biotechnology. 2008;26(11):1261-1268.
22. Sabalingam S, Siriwardhene MA. A review on Emerging applications of emulgel as topical drug Delivery system. World Journal of Advanced Research and Reviews. 2022;13(1):452463.
23.Patel RR, Patel KR, Patel MR. Formulation and Characterization of Microemulsion based Gel of Antifungal Drug, Pharma Tutor.2014;2(2):7989.17.

24.NiyazBB, Prakasam K, Goli
D.Formulation and evaluation of Gel containing Fluconazole Antifungal agent. IntJDrugDev Res.2011; 3.4:109-128
25.Granella, S.J.; Bechlin, T.R.; Christ, D.; Coelho, S.R.M.; de Oliveira Paz, C.H. An approach to recent applications of Moringa oleifera In the agricultural and biofuel industries. S. Afr. J. Bot. 2021, 137, 110–116.
26.Fahey, J.W., 2005. Moringa oleifera: A review of the medical evidence for its nutritional, therapeutic and prophylactic properties. Trees for life Journal, 1(5): 1-15.
27.Vinoth, B., R. Manivasagaperumal and S.Balamurugan, 2012. Phytochemical analysis and Antibacterial activity of Moringa oleifera Lam. Int. J.R Biol. Sci., 2(3): 98-102.
28.Olson, M.E., 1999. The home page of the plant family Moringaceae, Available at: www.mobot.org/Gradstudents/oslon/Moringahome.html.
29.Maurya, S.K.; Singh, A.K. Clinical Efficacy of Moringa oleifera Lam. Stems Bark in Urinary Tract Infections. Int. Sch. Res. Not.2014, 2014, 906843.
30.Singh, A.; Navneet. Ethnomedicinal, pharmacological and antimicrobial aspects of Moringa oleifera lam.: A review. J. Phytophar-Macol. 2018, 7, 45–50.
31.Bhattacharya, A.; Tiwari, P.; Sahu, P.K.; Kumar, S. A review of the phytochemical and pharmacological characteristics of Moringa Oleifera. J. Pharm. Bioallied Sci. 2018, 10, 181– 191.
32.Tan, W.S.; Arulselvan, P.; Karthivashan, G.; Fakurazi, S. Moringa oleifera Flower Extract Suppresses the Activation of Inflammatory Mediators in LipopolysaccharideStimulated RAW 264.7 Macrophages via NF-κB Pathway. Mediators Inflamm. 2015, 2015, 720171.
33.Foidl N, Makkar HPS, Becker K. The potential use of Moringa oleifera for agriculture and industrial uses. Managua, Nicaragua: 2001. Pp. 1–20. [Google Scholar]
34.Sharma VR, Paliwal R, Sharma S. Phytochemical analysis and evaluation of antioxidant activities of hydro-ethanolic extract of Moringa oleifera Lam. J Pharm Res. 2011;4(2):554– 7
35.Reynolds T, Dweck AC. Aloe vera gel leaf: a review update. J Ethnopharmacol.1999;68:3e37.
36.Foster M, Hunter D, Samman S. Evaluation of the nutritional and metabolic Effects of Aloe vera. In: Benzie IFF, Wachtel-Galor S, eds. Herbal Medicine: Bio-Molecular and Clinical Aspects. 2nd ed. Boca Raton: CRC; 2011.
37.Ghazanfar SA. Handbook of Arabian Medicinal plants. Boca Rato: CRC Press, 1994.
38.Richard LW .Aloe vera gel: Update for Dentistry. Pharmacology Today. 2005:6-9.
39.Josias HH. Composition and Applications of Aloe vera Leaf Gel. Molecules. 2008;13(8):1599-1616.
40.Hanley DC, Solomon WA, Saffran B, Davis RH the evaluation of natural substances in The treatment of adjuvant arthritis. J Am Podiatry Assoc. 1982;72:275-84.
41.Ito S, Teradaira R, Beppu H, Obata M, Nagatsu T, Fujita K. Properties and Pharmacological activity of Carboxypeptidase in Aloe arborescens Mill Var. Nasalises Berger. Phytotherapy Res.1993;7:S26-S9.
42.Meadows TP. Aloe as a humectant in new Skin preparations. Cosmetics Toiletries.1980;95:51-56.
43.Maxwell B, Chinnah H, Tizard I. Activated Macrophages accelerate wound healing in Aged rats. Wound Repair Regeneration.1996;4:165.
44.Oluwaseun RO, Adeniyi AO, Olusola OB, Oyindamola O. In vitro inhibitory potentials of ethanolic extract of Moringa oleifera flower against enzyme activities Linked to diabetes. Journal of Herbmed Pharmacology. 2021;10(4):408-414.
45.Napoleon P, Anitha J, Renitta RE. Isolation, analysis and identification of phytochemicals of antimicrobial Activity of Moringa oleifera Lam. International Journal Of Science and Technology. 2009;3(1).
46.Oluwaseun RO, Adeniyi AO, Olusola OB, Oyindamola O. In vitro inhibitory potentials of ethanolic extract of Moringa oleifera flower against enzyme activities linked to diabetes. Journal of Herbmed Pharmacology. 2021;10(4):408-414.
47.Yadav, J. P. & Kumar, S. Characterization and antibacterial activity of synthesized silver and iron nanoparticles using Aloe vera. J Nanomed Nanotechnology 7: 384. doi:10.4172/2157-7439.1000384.

Ahead of Print Subscription Review Article
Volume 13
01
Received 02/11/2025
Accepted 15/01/2026
Published 17/01/2026
Publication Time 76 Days
88

Login


My IP

PlumX Metrics